Mutant IDH1-IN-4
Based on 1 Customer Validation
Mutant IDH1-IN-4 (compound 434) is an inhibitor of mutant Isocitrate dehydrogenase 1 (IDH 1), with IC50 values of ≤ 0.5 μM for mutant IDH1 in R132H, HT1080 and U87R132H cells.
For research use only. We do not sell to patients.
- Purity : ≥99.0%
- CAS No.: 1416270-18-2
- Formula: C25H34N4O3
- Molecular Weight:438.56
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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IDH1 Inhibitor 1IDH Inhibitor
Biological Activity
Description
IC50 & Target
IC50: ≤ 0.5 μM (mutant IDH 1 in cells)[1].
Chemical Information
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CAS No. 1416270-18-2
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Appearance Solid
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Molecular Weight 438.56
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Formula C25H34N4O3
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Color Light yellow to yellow
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SMILES
N#CC1=C(N2C[C@@H](C3CC3)N(C(CCOC)=O)CC2)N=C(C4CC4)C5=C1CC(C)(C)OC5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
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Data Sheet (264 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. US20170210749A1.
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Mutant IDH1-IN-4 Related Classifications
HY-114459 Related Classifications
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