Colchicum brachyphyllum
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Colchicum brachyphyllum (1)
Cornigerine
- Formula: C21H21NO6
- Molecular Weight: 383.40
Cornigerine (Colchicine impurity H) is an antimitotic agent and tubulin antagonist. Cornigerine inhibits tubulin polymerization, blocks colchicine binding to tubulin, and stimulates tubulin-dependent GTP hydrolysis. Cornigerine induces metaphase arrest in leukemia cells and exhibits toxic activity against leukemia cells. Cornigerine can be used in research on mouse leukemia.
