6877-25-4
Chemical Structure
Cornigerine
Synonym(s): Colchicine impurity H
- No. CAS: 6877-25-4
- Formula:C21H21NO6
- Molecular Weight:383.40
IUPAC Name: (S)-N-(3,13-dimethoxy-4-oxo-4,6,7,8-tetrahydroheptaleno[1',2':4,5]benzo[1,2-d][1,3]dioxol-6-yl)acetamide
InChIKey: DCYAJVOKJAFSES-HNNXBMFYSA-N
SMILES: O(C)C1=C2C=3C([C@@H](NC(C)=O)CCC2=CC4=C1OCO4)=CC(=O)C(OC)=CC3
Biological Activity: Cornigerine (Colchicine impurity H) is an antimitotic agent and tubulin antagonist. Cornigerine inhibits tubulin polymerization, blocks colchicine binding to tubulin, and stimulates tubulin-dependent GTP hydrolysis. Cornigerine induces metaphase arrest in leukemia cells and exhibits toxic activity against leukemia cells. Cornigerine can be used in research on mouse leukemia[1].
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Cornigerine | Cornigerine (Colchicine impurity H) is an antimitotic agent and tubulin antagonist. Cornigerine inhibits tubulin polymerization, blocks colchicine binding to tubulin, and stimulates tubulin-dependent GTP hydrolysis. Cornigerine induces metaphase arrest in leukemia cells and exhibits toxic activity against leukemia cells. Cornigerine can be used in research on mouse leukemia. | |||||||||||||||||||||
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