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Cat. No.: HY-Z16793

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Cornigerine

Name: Cornigerine
Brand: MedChemExpress
SKU: HY-Z16793
Availability: PreOrder

(Synonyms: Colchicine impurity H)

Cornigerine (Colchicine impurity H) is an antimitotic agent and tubulin antagonist. Cornigerine inhibits tubulin polymerization, blocks colchicine binding to tubulin, and stimulates tubulin-dependent GTP hydrolysis. Cornigerine induces metaphase arrest in leukemia cells and exhibits toxic activity against leukemia cells. Cornigerine can be used in research on mouse leukemia.

For research use only. We do not sell to patients.

CAS No.: 6877-25-4
Formula: C₂₁H₂₁NO₆
Molecular Weight:383.40

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Cornigerine Chemical Structure

CAS No.: 6877-25-4

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Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
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Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
L1210	IC50	0.02-0.04 μM	Inhibition of murine leukemia L1210 cell growth assessed after 24 hours incubation. Inhibition of murine leukemia L1210 cell growth assessed after 24 hours incubation.	0006295288903723

In Vitro

Cornigerine (0.01-0.3 μM; 6-24 h) potently inhibits the growth of L1210 mouse leukemia cells with an IC₅₀ of 0.02-0.04 μM and induces mitotic arrest in these cells^[1].
Cornigerine (0.1 mM; 0-60 min; 37°C) inhibits the early phase of tubulin-dependent GTP hydrolysis by purified bovine brain tubulin (assembled with heat-treated microtubule-associated proteins)^[1].
Cornigerine is a microtubule assembly inhibitor that is more potent than colchicine in a reconstituted system containing purified bovine brain tubulin and heat-treated microtubule-associated proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

Cell Cytotoxicity Assay^[1]

View Protocol

Cell Line:

L1210 murine leukemia cells
Concentration:

0.01-0.3 μM (cell growth assay); 0.01-0.3 μM (mitotic arrest assay)
Incubation Time:

24 h (cell growth assay); 6 h (mitotic arrest assay)
Result:

Inhibited L1210 cell growth with an IC₅₀ ranging from 0.02 to 0.04 μM.
Caused accumulation of cells arrested in mitosis at cytotoxic concentrations.

Chemical Information

CAS No. 6877-25-4
Molecular Weight 383.40
Formula C₂₁H₂₁NO₆
SMILES

O(C)C1=C2C=3C([C@@H](NC(C)=O)CCC2=CC4=C1OCO4)=CC(=O)C(OC)=CC3
Synonyms

Colchicine impurity H
Structure Classification
- Others
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Hamel E, et al. Cornigerine, a potent antimitotic Colchicum alkaloid of unusual structure: interactions with tubulin[J]. Biochemical pharmacology, 1988, 37(12): 2445-2449.

[2]. Roesner M, et al. Synthesis of two aromatic methylenedioxy-substituted colchicine congeners: elucidation of the structure of cornigerine as 2, 3-(methylenedioxy)-2, 3-didemethoxycolchicine[J]. The Journal of Organic Chemistry, 1981, 46(18): 3686-3688.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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