Infection

3-ANOT (Standard) is the analytical standard of 3-ANOT. This product is intended for research and analytical applications. 3-ANOT is a metabolite of Dinitolmide (a nitroamide coccidiostat commonly used in poultry production).

SARS-CoV-2 PLpro-IN-6 is an irreversible SARS-CoV-2 papain-like protease inhibitor with an IC₅₀ value of 0.059 μM. SARS-CoV-2 PLpro-IN-6 exhibits antiviral activity and can be used in studies related to COVID-19.

Leucomycin A4 is a macrolide antibiotic that can be extracted from S. kitasatoensis. Leucomycin A4 inhibits a variety of bacteria, including S. aureus, B. subtilis, C. diphtheriae, N. gonorrhoeae, and H. influenzae (MICs = 0.15, 1.25, 0.15, 0.6, and 0.15 µg/ml, respectively).

BAY-Y 3118 hydrochloride is a quinolone antibacterial agent. BAY-Y 3118 hydrochloride has a broad antibacterial spectrum in vitro. BAY-Y 3118 hydrochloride exhibits high activity against gram-positive cocci and anaerobes. BAY-Y 3118 hydrochloride shows moderate activity against Enterobacteriaceae and Pseudomonas aeruginosa. BAY-Y 3118 hydrochloride can be used in the research of infectious diseases.

Antibacterial agent 354 is a bactericide targeting the LolCDE complex, with broad-spectrum activity against phytopathogens. Antibacterial agent 354 regulates gene expression, disrupts lipoprotein transport and inhibits bacterial division. Antibacterial agent 354 prevents and controls rice bacterial blight and kiwifruit canker in plant models, and is used in relevant studies.

Lactoquinomycin B is a quinone antibiotic. Lactoquinomycin B has the activity of anti-Gram-positive bacteria and some Gram-negative bacteria, but the effect of anti-Gram-negative bacteria is weak and has no effect on fungi. Lactoquinomycin B inhibits a variety of cell lines including lymphoma L5178Y progenitor, Adriamycin resistant, Bleomycin-resistant, human leukemia K562, mouse leukemia L-1210 and mouse leukemia P 388 with ID₅₀ (μg/mL) of 0.43, 0.21, 0.19, 0.16, 0.2 and 0.12, respectively.

Cephalosporin C analog-1 sodium is an analogue of Cephalosporin C (HY-B1299). Cephalosporin C has weak resistance to Gram-positive and negative bacteria, is stable to penicillinase, and can be broken down by cephalosporin enzyme. Hydrolysis and removal of side chains to obtain 7-amino-cefenoic acid (7-ACA) is an important raw material for the preparation of semi-synthetic cephalosporin.

Ceftizoxime (Standard) is the analytical standard of Ceftizoxime. This product is intended for research and analytical applications. Ceftizoxime is a bacterial inhibitor which acts by interfering with bacterial cell wall synthesis and inhibiting cross-linking of the peptidoglycan.

Laccase-IN-5 (Compound 2b) is the inhibitor for Laccase with an IC₅₀ of 0.82 μM. Laccase-IN-5 increases the cell membrane permeability, limits the growth of hyphae, destorys the cell wall, and induces oxidative stress responses. Laccase-IN-5 exhibits antifungal activity against various plant pathogenic fungi and oomycetes, inhibits B. dothidea with an EC₅₀ of 0.96 mg/L.

Antifungal agent 144 (Compound 3f) is a highly selective antifungal agent against Aspergillus niger, with an MIC of 7.5 μg/mL. Antifungal agent 144 simultaneously inhibits chitin deacetylase AngCDA and 1,3-β-glucan synthase. Antifungal agent 144 functions by disrupting the integrity of the fungal cell wall and does not bind to Ergosterol (HY-N0181). Antifungal agent 144 can be used for research on Aspergillus niger infections.

Baumycin B1 is an antitumor antibiotic.

2-Deoxy-20-hydroxyecdysone-22-phosphate is an inactive storage form of insect ecdysteroids. 2-Deoxy-20-hydroxyecdysone-22-phosphate exists in newly laid eggs of the desert locust Schistocerca gregaria. 2-Deoxy-20-hydroxyecdysone-22-phosphate can be enzymatically hydrolyzed by embryonic tissues to release the ecdysteroid 2-deoxy-20-hydroxyecdysone (HY-N17267).

SARS-CoV-2 Mpro-IN-54 is a SARS-CoV-2 main protease (Mpro) inhibitor with an IC₅0 of 12.5 nM against SARS-CoV-2 Mpro. SARS-CoV-2 Mpro-IN-54 functionally inhibits SARS-CoV-2 main protease activity. SARS-CoV-2 Mpro-IN-54 can be used for the research of COVID-19.

Lincomycin (U-10149) hydrochloride monohydrate (Standard) is the analytical standard of Lincomycin hydrochloride monohydrate (HY-B1358). This product is intended for research and analytical applications. Lincomycin hydrochloride monohydrate is an orally active lincosamide antibiotic. Lincomycin hydrochloride monohydrate binds to the ribosomes of Gram-positive bacteria to inhibit protein synthesis. Lincomycin hydrochloride monohydrate can inhibit chloroplast translation, disrupt chloroplast integrity, and activate chloroplast-to-nucleus retrograde signaling in Arabidopsis thaliana seedlings. Lincomycin hydrochloride monohydrate induces alterations in lipid profiles and liver injury, disrupts blood glucose and insulin levels, and increases growth rate in mice.

Napsamycin B is an antibiotic. Napsamycin B has antibacterial activity against Pseudomonas aeruginosa and other pseudomonas, but has weak antibacterial activity against other Gram-positive and negative bacteria.

hDHODH-IN-17 (Compound 10) is a human dihydroorotate dehydrogenase (hDHODH) inhibitor, with an IC₅₀ of 0.188 μM. hDHODH-IN-17 is in good agreement with the hDHODH activity pocket and interacted well with amino acid residues. hDHODH-IN-17 is the potential broad-spectrum antiviral agent.

pro-N6pA is a cell-permeable pronucleotide probe. Pro-N6pA can be used to track AMPylated proteins. Pro-N6pA can also be used in bacterial infection research.

Cefoxazole is a β-lactam antibiotic containing an isoxazole moiety and exhibits antibacterial activity. Cefoxazole can be used in studies related to infectious diseases.

J1038 (T 5979345) is a selective HDAC8 inhibitor. J1038 binds the catalytic zinc ion of Schistosoma mansoni HDAC8 (smHDAC8).

5-(Pyridin-4-yl)-1,3,4-oxadiazole-2-thiol (Compound 3n) is an antimicrobial and antioxidant agent, that inhibits Escherichia coli and Staphylococcus epidermidis, with MIC of 8 and 4 μg/mL. 5-(Pyridin-4-yl)-1,3,4-oxadiazole-2-thiol exhibits antioxidant activity with IC₅₀ of 17.47 μM using DPPH free radical-scavenging method.