Antibacterial agent 354
Antibacterial agent 354 is a bactericide targeting the LolCDE complex, with broad-spectrum activity against phytopathogens. Antibacterial agent 354 regulates gene expression, disrupts lipoprotein transport and inhibits bacterial division. Antibacterial agent 354 prevents and controls rice bacterial blight and kiwifruit canker in plant models, and is used in relevant studies.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Formel: C16H12N4
- Molecular Weight:260.29
-
Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biologische Aktivität
-
Chemical Information
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
Biologische Aktivität
Beschreibung
In Vitro
Antibacterial agent 354 (compound II-28) (50 μg/mL) potently inhibits the growth of Xoo, Psa, and Rs, and moderately inhibits Xcc and Ac when tested at 50 μg/mL in vitro[1].
Antibacterial agent 354 displays broad-spectrum in vitro antibacterial activity with an MIC50 of 12.5 μg/mL against Xoo, Psa, and Rs, an MIC50 of 50.0 μg/mL against Xcc, and no activity against Ac at concentrations up to 50.0 μg/mL[1].
Antibacterial agent 354 (1/4 × MIC-3 × MIC) up-regulates the expression of Lol system genes in Xoo, providing transcriptional evidence that it impairs the Lol transport system[1].
Antibacterial agent 354 (1/4 × MIC-3 × MIC; 12 h) disrupts Xoo cell morphology and inhibits cell division in a concentration-dependent manner, with severe membrane damage observed at 3 × MIC[1].
Antibacterial agent 354 (1/4 × MIC-3 × MIC; 12 h) damages Xoo cell ultrastructure in a concentration-dependent manner, leading to ribosome aggregation, cytoplasm loss, nucleoid pyknosis, and cell wall breakdown at the highest tested concentration[1].
Antibacterial agent 354 (1/4 × MIC-3 × MIC; 30 h) inhibits Xoo growth in a concentration-dependent manner, with near-complete growth inhibition observed at 3 × MIC over 30 h[1].
Antibacterial agent 354 (1/4 × MIC-1 × MIC; 48−72 h) inhibits Xoo biofilm formation in a concentration-dependent manner, with 68.3% inhibition observed at 1 × MIC[1].
Antibacterial agent 354 (1/4 × MIC-1 × MIC; 5 days) reduces Xoo EPS production in a concentration-dependent manner, with 58.5% reduction observed at 1 × MIC[1].
Antibacterial agent 354 (1/4 × MIC-3/4 × MIC; 5 days) inhibits Xoo motility in a concentration-dependent manner, with 56.0% inhibition observed at 3/4 × MIC[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Antibacterial agent 354 (II-28) (4-64 μg/mL; aqueous exposure; every 24 h; 96 h) has a 96 h LC50 of 18.15 mg/L in Danio rerio larvae, indicating low acute fish toxicity[1].
Antibacterial agent 354 (100 mg a.i./kg dry soil; soil exposure; 14 days) has an LC50 greater than 100 mg a.i./kg dry soil in Eisenia fetida earthworms, indicating low soil organism toxicity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Sprague-Dawley (SD) (8-week-old, female)[1]
-
Dosage:175 mg/kg; 555 mg/kg; 1750 mg/kg; 3100 mg/kg
-
Administration:p.o.; single dose
-
Result:Exhibited reduced activity, rapid breathing, and death within 24 h at 3100 mg/kg.
Showed no toxic reactions or deaths at 175 mg/kg, 555 mg/kg, and 1750 mg/kg.
Calculated an acute oral LD50 of 2500 mg/kg body weight.
-
Animal Model:Danio rerio larvae (120 hpf)[1]
-
Dosage:4 μg/mL; 8 μg/mL; 16 μg/mL; 32 μg/mL; 64 μg/mL
-
Administration:aqueous exposure; every 24 h; 96 h
-
Result:Increased mortality with concentration and exposure duration.
Determined a 96 h median lethal concentration (LC50) of 18.15 mg/L.
-
Animal Model:Adult Eisenia fetida earthworms[1]
-
Dosage:100 mg a.i./kg dry soil
-
Administration:soil exposure; 14 days
-
Result:Showed no significant effects on growth or survival on days 7 and 14.
Determined an LC50 greater than 100 mg a.i./kg dry soil.
Chemical Information
-
Molecular Weight 260.29
-
Formel C16H12N4
-
SMILES
C12=C(NC=C2)C=C(C3=NNC=C3C4=CC=NC=C4)C=C1
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Antibacterial agent 354 Related Classifications
HY-184421 Related Classifications
Powered by Bioz