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Cat. No.: HY-184421

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Antibacterial agent 354

Antibacterial agent 354 is a bactericide targeting the LolCDE complex, with broad-spectrum activity against phytopathogens. Antibacterial agent 354 regulates gene expression, disrupts lipoprotein transport and inhibits bacterial division. Antibacterial agent 354 prevents and controls rice bacterial blight and kiwifruit canker in plant models, and is used in relevant studies.

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화학식: C₁₆H₁₂N₄
분자량:260.29

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Antibacterial agent 354 Chemical Structure

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Use of MCE Products

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

In Vitro

Antibacterial agent 354 (compound II-28) (50 μg/mL) potently inhibits the growth of Xoo, Psa, and Rs, and moderately inhibits Xcc and Ac when tested at 50 μg/mL in vitro^[1].
Antibacterial agent 354 displays broad-spectrum in vitro antibacterial activity with an MIC₅₀ of 12.5 μg/mL against Xoo, Psa, and Rs, an MIC₅₀ of 50.0 μg/mL against Xcc, and no activity against Ac at concentrations up to 50.0 μg/mL^[1].
Antibacterial agent 354 (1/4 × MIC-3 × MIC) up-regulates the expression of Lol system genes in Xoo, providing transcriptional evidence that it impairs the Lol transport system^[1].
Antibacterial agent 354 (1/4 × MIC-3 × MIC; 12 h) disrupts Xoo cell morphology and inhibits cell division in a concentration-dependent manner, with severe membrane damage observed at 3 × MIC^[1].
Antibacterial agent 354 (1/4 × MIC-3 × MIC; 12 h) damages Xoo cell ultrastructure in a concentration-dependent manner, leading to ribosome aggregation, cytoplasm loss, nucleoid pyknosis, and cell wall breakdown at the highest tested concentration^[1].
Antibacterial agent 354 (1/4 × MIC-3 × MIC; 30 h) inhibits Xoo growth in a concentration-dependent manner, with near-complete growth inhibition observed at 3 × MIC over 30 h^[1].
Antibacterial agent 354 (1/4 × MIC-1 × MIC; 48−72 h) inhibits Xoo biofilm formation in a concentration-dependent manner, with 68.3% inhibition observed at 1 × MIC^[1].
Antibacterial agent 354 (1/4 × MIC-1 × MIC; 5 days) reduces Xoo EPS production in a concentration-dependent manner, with 58.5% reduction observed at 1 × MIC^[1].
Antibacterial agent 354 (1/4 × MIC-3/4 × MIC; 5 days) inhibits Xoo motility in a concentration-dependent manner, with 56.0% inhibition observed at 3/4 × MIC^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Antibacterial agent 354 (compound II-28) (175-3100 mg/kg; p.o.; single dose) has an acute oral LD₅₀ of 2500 mg/kg in female Sprague-Dawley rats, indicating low mammalian acute oral toxicity^[1].
Antibacterial agent 354 (II-28) (4-64 μg/mL; aqueous exposure; every 24 h; 96 h) has a 96 h LC₅₀ of 18.15 mg/L in Danio rerio larvae, indicating low acute fish toxicity^[1].
Antibacterial agent 354 (100 mg a.i./kg dry soil; soil exposure; 14 days) has an LC₅₀ greater than 100 mg a.i./kg dry soil in Eisenia fetida earthworms, indicating low soil organism toxicity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Sprague-Dawley (SD) (8-week-old, female)^[1]
Dosage:

175 mg/kg; 555 mg/kg; 1750 mg/kg; 3100 mg/kg
Administration:

p.o.; single dose
Result:

Exhibited reduced activity, rapid breathing, and death within 24 h at 3100 mg/kg.
Showed no toxic reactions or deaths at 175 mg/kg, 555 mg/kg, and 1750 mg/kg.
Calculated an acute oral LD₅₀ of 2500 mg/kg body weight.

Animal Model:

Danio rerio larvae (120 hpf)^[1]
Dosage:

4 μg/mL; 8 μg/mL; 16 μg/mL; 32 μg/mL; 64 μg/mL
Administration:

aqueous exposure; every 24 h; 96 h
Result:

Increased mortality with concentration and exposure duration.
Determined a 96 h median lethal concentration (LC₅₀) of 18.15 mg/L.

Animal Model:

Adult Eisenia fetida earthworms^[1]
Dosage:

100 mg a.i./kg dry soil
Administration:

soil exposure; 14 days
Result:

Showed no significant effects on growth or survival on days 7 and 14.
Determined an LC₅₀ greater than 100 mg a.i./kg dry soil.

Chemical Information

분자량 260.29
화학식 C₁₆H₁₂N₄
SMILES

C12=C(NC=C2)C=C(C3=NNC=C3C4=CC=NC=C4)C=C1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Li Q, et al. Designing Biaryl Pyrazole Derivatives for Antibacterial Activity against Plant Pathogenic Bacteria. Journal of agricultural and food chemistry. 2026 Jun 10;74(22):16919-16931. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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