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Cat. No.: HY-181162

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SARS-CoV-2 Mpro-IN-54

SARS-CoV-2 Mpro-IN-54 is a SARS-CoV-2 main protease (Mpro) inhibitor with an IC₅0 of 12.5 nM against SARS-CoV-2 Mpro. SARS-CoV-2 Mpro-IN-54 functionally inhibits SARS-CoV-2 main protease activity. SARS-CoV-2 Mpro-IN-54 can be used for the research of COVID-19.

For research use only. We do not sell to patients.

Formula: C₃₀H₄₉BN₆O₆
Molecular Weight:600.56

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

SARS-CoV-2 Mpro-IN-54 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

In Vitro

SARS-CoV-2 MPro-IN-54 (compound 51) (30 min) potently inhibits SARS-CoV-2 main protease with an IC₅₀ of 12.5 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 600.56
Formula C₃₀H₄₉BN₆O₆
SMILES

CC1(C)OB(C(N(C(C(N2[C@H](C(N[C@H](C#N)C[C@H]3C(NCC3)=O)=O)[C@@H]4[C@@H](C4(C)C)C2)=O)C(C)(C)C)C(N)=O)C)OC1(C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Gyasi YI, et al. Regioselective multicomponent synthesis of α-boryl ureas: discovery of a potent main protease inhibitor. Org Biomol Chem. 2026;24(5):1033-1041. Published 2026 Feb 4. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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