Infection

Canthin-6-one N-oxide (Canthin-6-one 3-oxide) is an orally active antiparasitic agent with limited activity.

Antibiofilm agent-23 is a PqsR-targeting agent, iron chelator, biofilm inhibitor, biofilm dispersant, and anti-virulence agent. Antibiofilm agent-23 selectively binds to PqsR, disrupts the pqs quorum sensing pathway, restricts bacterial iron acquisition, induces intracellular iron deficiency, reduces pyocyanin, elastase, and rhamnolipid production, impairs biofilm formation, and disperses mature biofilms. Antibiofilm agent-23 exhibits low cytotoxicity and shows antibacterial synergy with Ciprofloxacin (HY-B0356) in Caenorhabditis elegans infection models. Antibiofilm agent-23 can be used for the research of biofilm-associated Pseudomonas aeruginosa infections.

Oridonin (Standard) is the analytical standard of Oridonin. This product is intended for research and analytical applications. Oridonin (NSC-250682), a diterpenoid isolated from Rabdosia rubescens, acts as an inhibitor of AKT, with IC50s of 8.4 and 8.9 μM for AKT1 and AKT2; Oridonin possesses anti-tumor, anti-bacterial and anti-inflammatory effects.

MRSA antibiotic 2 (compound 2) shows MIC of 2 μg/mL for S. aureus (MRSA). MRSA antibiotic 2 selectively target Gram-positive bacteria over Gram-negative bacteria and human cells.

Cetalkonium (chloride) (Standard) is the analytical standard of Cetalkonium (chloride). This product is intended for research and analytical applications. Cetalkonium chloride is an ammonium antiseptic agent used in many topical agents for infections of mouth, throat and eye. Cetalkonium chloride acts as anti-inflammatory amphiphilic agent. Cetalkonium chloride is a cationic surfactant, that improves the precorneal residence time and bioavailability of drugs. Cetalkonium chloride interacts with the negative charges on the bacterial cell membrane, disrupts the integrity of the cell membrane, causes leakage of cell contents and ultimately leading to bacterial death.

RNA polymerase-IN-3 (Compound 28) is a bacterial RNA polymerase (RNAP) inhibitor with antibacterial activity. RNA polymerase-IN-3 inhibits RNA synthesis by competitively blocking the binding of UTP to RNAP (IC₅₀= 0.28 μM). RNA polymerase-IN-3 is promising for research of bacterial infections.

Epoxiconazole-d4 is the deuterium labeled Epoxiconazole (HY-119683). Epoxiconazole, a fungicide, is a demethylation inhibitor of the Ergosterol biosynthesis pathway. Epoxiconazole exhibits strong inhibitory effects on both carbendazim-resistant and phenamacril-resistant isolates, and can be used for controlling many crop diseases.

Diclazuril (R-64433) potassium, a benzeneacetonitrile derivative, is a potent and orally active anticoccidial agent. Diclazuril potassium can be used for the research of certain infectious and parasitic diseases, including coccidiosis, acute toxoplasmosis, equine protozoal pyoencephalitis (EPM) et.al.

Apo-Enopeptin methyl ester is a derivative of Enopeptin A (HY-P1708). Apo-Enopeptin methyl ester is promising for research of Gram-positive and Gram-negative bacteria.

Meclocycline (Sulfosalicylate Salt) (Standard) is the analytical standard of Meclocycline (Sulfosalicylate Salt). This product is intended for research and analytical applications. Meclocycline Sulfosalicylate Salt is a tetracycline antibiotic with broad-spectrum antibacterial activities, preventing skin bacterial infections such as acne vulgaris.

Orbifloxacin-d₄ is deuterium labeled Orbifloxacin.

2"-N-Formimidoylsporaricin A has the activity of anti-Gram-positive bacteria and negative bacteria, and also has the antibacterial activity against the aminoglycol-resistant bacteria.

Feglymycin is a HIV replication inhibitor. Feglymycin is also an antibiotic peptide that has antibacterial activity (MIC: 32-64 μg/mL for Staphylococcus aureus).

MED6-189, a kalihinol analog, disrupts apicoplast function and vesicular trafficking in P. falciparum malaria (IC₅₀ < 50 nM). MED6-189 targets the apicoplast, a nonphotosynthetic plastid found in most Apicomplexa parasites that is crucial for the synthesis of isoprenoids.

Thiamphenicol-d₃-1 (Thiophenicol-d₃-1; Dextrosulphenidol-d₃-1) is the deuterium-labeled Thiamphenicol (HY-B0479). Thiamphenicol (Thiophenicol), a methyl-sulfonyl derivative of Chloramphenicol, is a broad-spectrum antimicrobial antibiotic. Thiamphenicol acts by binding to the 50S ribosomal subunit, leading to inhibition of protein synthesis and bacteriostatic effect (against Gram-negative, Gram-positive aerobic and anaerobic bacteria).

SARS-CoV-2 Mpro-IN-30 (compound L2) is a SARS-CoV-2 Mpro with the IC₅₀ of 9.1 nM.

CYP51-IN-31 (compound T24) is a selective CYP51 inhibitor with potent and broad-spectrum antifungal activity, including efficacy against drug-resistant fungal strains. CYP51-IN-31 exhibits fungicidal activity against Candida parapsilosis, anti-biofilm activity, and the ability to inhibit fungal morphological transitions. CYP51-IN-31 can be used for infection research.

Baquiloprim (Standard) is the analytical standard of Baquiloprim (HY-19581). This product is intended for research and analytical applications. Baquiloprim is an orally active Antibiotic and selective inhibitor of Bacterial Dihydrofolate reductase (DHFR), with an IC₅₀ of 19 nM against E. coli and an IC₅₀ of 190 μM against rat liver dihydrofolate reductase. Baquiloprim is a bacteriostatic broad-spectrum antibacterial agent that acts against Gram-negative and Gram-positive bacteria. Baquiloprim inhibits glucuronidation in cultured hepatocytes. Baquiloprim can be used in research related to Pasteurella haemolytica infection, bacterial infection, Escherichia coli diarrhea, bacterial infection in pigs, and pneumonic pasteurellosis.

GW844520 is an orally active inhibitor of cytochrome bc1 complex. GW844520 can be used in malaria and anti-plasmodium related research.

Manumycin E has anti-Gram-positive bacteria and Escherichia coli effects, but the effect is very weak against other anti-Gram-negative bacteria, and has no effect on fungi. Manumycin E inhibits RAS Faraday base transfer and has weak cytotoxic activity against human cloned cancer cell lines HCT-116 (IC₅₀ is 15.6 μg/mL).