Infection

CMX-521, a nucleoside analog, is a potent inhibitor for RNA-dependant RNA polymerase (RdRp) of norovirus. CMX-521 suppresses murine norovirus (MNV) and human norovirus.

Napsamycin C is an antibiotic. Napsamycin C has antibacterial activity against Pseudomonas aeruginosa and other pseudomonas, but has weak antibacterial activity against other Gram-positive and negative bacteria.

Enaminomycin B has anti-Gram positive bacteria and negative bacteria activity.

N-cis-octadec-9Z-enoyl-L-Homoserine lactone is a potent inhibitor of AhyI. AhyI (expressing acylhomoserine lactone) is responsible for the biosynthesis of autoinducer-1 (AI-1), commonly referred to as a quorum sensing (QS) signaling molecule, which plays an essential role in bacterial communication. N-cis-octadec-9Z-enoyl-L-Homoserine lactone is a competitive inhibitor of AI-1 biosynthesis.

Platenomycin A0 is a macrolide antibiotic with anti-Gram-positive bacteria activities.

Endophenazine D is a phenazine antibiotic.

Boceprevir (Standard) is the analytical standard of Boceprevir. This product is intended for research and analytical applications. Boceprevir (EBP 520) is a potent, highly selective, orally bioavailable HCV NS3 protease inhibitor with a K_i of 14 nM in both enzyme assay and an EC₉₀ of 350 nM in cell-based replicon assay. Boceprevir inhibits SARS-CoV-2 3CL^pro activity.

N-3-Hydroxydecanoyl-L-homoserine lactone is a type of N-acyl-L-homoserine lactone (AHL), which is a class of signaling molecules in bacterial quorum sensing systems, and it has a weak activating effect on AbaR.

WEHI-326 is a potent antimalarial agent targeting Plasmodium falciparum ROM8 and CSC1 proteins (IC₅₀=0.006 μM). WEHI-326 is promising for research of malaria.

Bayer 9017 is an insecticide with plasma cholinesterase inhibitory activity and toxicity. Bayer 9017 inhibits plasma cholinesterase activity in chicks. Bayer 9017 prevents the colonization of Lucilia sericata larvae, kills first-instar Lucilia sericata larvae, and provides myiasis protection for sheep, with seasonal variations in its protective performance. Bayer 9017 is applicable to research related to myiasis.

Quinine hydrochloride (Standard) is the analytical standard of Quinine (hydrochloride) (HY-110082). This product is intended for research and analytical applications. Quinine (hydrochloride) is an alkaloid derived from the bark of the cinchona tree, acts as an anti-malaria agent. Quinine (hydrochloride) is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100 mV with an IC₅₀ of 169 μM.

M&B 4935 is an orally active Amoebicide. M&B 4935 reduces the levels of *Entamoeba histolytica* parasites in rodents. M&B 4935 can be used for the research of amoebiasis.

Escin IA (Standard) is the analytical standard of Escin IA. This product is intended for research and analytical applications. Escin IA is a triterpene saponin isolated from Aesculus hippocastanum, which inhibits HIV-1 protease with IC50 values of 35 μM. Escin IA has anti-TNBC metastasis activity, and its action mechanisms involved inhibition of epithelial-mesenchymal transition process by down-regulating LOXL2 expression.

PD 0305970 is an orally active bacterial gyrase and topoisomerase inhibitor. PD 0305970 shows exceptional activity against gram-positive and fastidious organisms and more modest activity against gram-negative species. PD 0305970 shows low spontaneous resistance frequencies. PD 0305970 shows antibacterial efficacy in murine streptococcal sepsis and pneumococcal pneumonia models. PD 0305970 can be used for the research of bacterial infection.

Ethyl 10-bromodecanoate is an antiinflammatory and hemostatic agent. Ethyl 10-bromodecanoate is a member of the family of linolenic acid, which includes diethyl succinate and ethyl palmitate. Ethyl 10-bromodecanoate has been shown to have antibacterial properties.

Sceptrin dihydrochloride is a compound isolated from the sea sponge Agelas sceptrum that is an antimicrobial agent.

Bictegravir-d₇ (GS-9883-d₇) is deuterium labeled Bictegravir. Bictegravir (GS-9883) is a potent inhibitor of HIV-1 integrase with an IC₅₀ of 7.5 nM.

Nitrocefin (Standard) is the analytical standard of Nitrocefin. This product is intended for research and analytical applications. Nitrocefin is a chromogenic β-lactamase substrate that undergoes a distinctive color change from yellow to red as the amide bond in the β-lactam ring is hydrolyzed by β-lactamase. Nitrocefin is used in competitive inhibition studies in developmental work on β-lactamase-resistant antibiotics.

Rifabutin-vonoprazan conjugate 1 is an orally active acid-responsive bifunctional molecule. Rifabutin-vonoprazan conjugate 1 exhibits anti-Helicobacter pylori activity (MIC ≤ 0.125 μg/mL) and acid-suppressive effects (acid inhibition rate > 85% at a dose of 2 mg/kg). Rifabutin-vonoprazan conjugate 1 also demonstrates anti-ulcer activity. Rifabutin-vonoprazan conjugate 1 can be used in research related to Helicobacter pylori infection and gastric ulcer.

Maridomycin IV is a macrolide antibiotic. Maridomycin IV has the activity against Gram-positive bacteria and mycoplasma. Maridomycin IV has the effect of protecting Gram-positive bacterial infection mice.