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Cat. No.: HY-129514

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Bayer 9017

Bayer 9017 is an insecticide with plasma cholinesterase inhibitory activity and toxicity. Bayer 9017 inhibits plasma cholinesterase activity in chicks. Bayer 9017 prevents the colonization of Lucilia sericata larvae, kills first-instar Lucilia sericata larvae, and provides myiasis protection for sheep, with seasonal variations in its protective performance. Bayer 9017 is applicable to research related to myiasis.

For research use only. We do not sell to patients.

CAS No.: 52-60-8
Formula: C₁₃H₂₁O₃PS₂
Molecular Weight:320.40

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Please store the product under the recommended conditions in the Certificate of Analysis.

Bayer 9017 Chemical Structure

CAS No.: 52-60-8

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Biological Activity
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- In Vivo
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Biological Activity

Description

All Parasite Isoforms :

All Cholinesterase (ChE) Isoforms :

AChE
BChE

In Vivo

Bayer 9017 (200-800 ppm; oral administration; daily dosing; for 3 weeks) exhibits acute oral toxicity in young White Leghorn roosters, with an LD₅₀ of 17.9 mg/kg. In contrast, subacute toxicity induced via feed administration causes dose-dependent mortality, plasma cholinesterase inhibition and initial growth retardation, while the growth of surviving individuals gradually recovers over time^[1].
Bayer 9017 (250-400 ppm; medicated bath immersion; single dose) provides sheep with complete protection against myiasis for at least 10-20 weeks and partial protection for 14-24 weeks^[2].
Bayer 9017 (400 ppm; administered via a single dipping treatment) provides 16-26 weeks of protection against artificial myiasis in Romney sheep, with a residual duration of 18-30 weeks in wool^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Single Comb White Leghorn cockerels (10- to 12-day-old)^[1]
Dosage:

17.9 mg/kg (acute study); 200-800 ppm (subacute study)
Administration:

p.o.; single dose (acute study); daily; 3 weeks (subacute study)
Result:

Determined an LD₅₀ of 17.9 mg/kg, with all deaths emerging within 8 hours after exposure.
Triggered full lethality by week 2 at 800 ppm, accompanied by 5% week 1 mortality, 94% plasma cholinesterase suppression and reduced week 1 weight-gain ratio of 0.77.
Produced cumulative 45% mortality by week 3 at 400 ppm, including 0% week 1 death and 25% week 2 death; brought about 92% week 1 and 100% week 2 plasma cholinesterase inhibition, alongside lowered week 1 and week 2 weight-gain ratios of 1.01 and 1.12.
Led to zero mortality within 3 weeks at 200 ppm, induced 83% week 1 and 86% week 2 plasma cholinesterase inhibition, and generated decreased week 1 weight-gain ratio of 1.30 and week 2 ratio of 1.36; surviving subjects exhibited growth exceeding control levels after early exposure stage.

Chemical Information

CAS No. 52-60-8
Molecular Weight 320.40
Formula C₁₃H₂₁O₃PS₂
SMILES

S=P(OC=1C=C(C(SC)=C(C1)C)C)(OCC)OCC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Sherman M, et al. Further studies on the acute and subacute toxicity of insecticides to chicks. Toxicology and Applied Pharmacology, 1967, 11(1): 49-67.

[2]. Millar E S. Fly-strike control in sheep: An evaluation of further new compounds. New Zealand Veterinary Journal, 1966, 14(12): 215-216.

[3]. Heath AC. New insecticides: as sheep dips against Lucilia sericata. N Z Vet J. 1971 Mar;19(3):45-6. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- In Vivo
Chemical Information
Purity & Documentation
References

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Bayer 9017

All Parasite Isoforms

All Cholinesterase (ChE) Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Bayer 9017 Related Classifications

HY-129514 Related Classifications