Infection

Dienochlor (Decachlor) is a miticide that inhibits Mexican bean beetle, Epilachna varivestis Mulsant, from laying eggs on pinto beans.

Isolubimin is a sesquiterpenoid phytoalexin found in Datura stramonium fruits with antibacterial activity. Isolubimin is promising for research of plant disease caused by fungal infections.

Antiparasitic agent-45 is an orally active schistosomicidal agent against Schistosoma mansoni. Antiparasitic agent-45 exerts schistosomicidal activity against Schistosoma mansoni in mice. Antiparasitic agent-45 does not induce ocular reactions in cats. Antiparasitic agent-45 can be used for the research of schistosomiasis.

(E/Z)-N-p-trans-Coumaroyltyramine is an amide. (E/Z)-N-p-trans-Coumaroyltyramine is present in the leaves of Annona muricata L. (E/Z)-N-p-trans-Coumaroyltyramine exhibits certain brine shrimp larvicidal activity.

Pivmecillinam (FL-1039) is an orally active proagent of mecillinam, an extended-spectrum penicillin antibiotic.

1,1,3-Tris (3-indolyl) butane is an indole alkaloid. It is isolated from North Sea bacteria closely related to Vibrio parahaemolyticus. 1,1,3-Tris (3-indolyl) butane shows no activity against a variety of bacteria and fungi.

3',4'-Didehydro-3'-deoxycytidine is an endogenous deoxycytidine analog and antiviral agent. 3',4'-Didehydro-3'-deoxycytidine is a host response marker that can cross the plasma membrane, and it can be used in studies related to COVID-19, dengue fever, Zika virus disease, West Nile virus disease, hepatitis C, and other conditions.

BMS-986144 non-deuterated is the non-tritium form of BMS-986144 (HY-131905S). BMS-986144 is an orally active inhibitor of HCV NS3/4A protease. BMS-986144 binds to the active site of HCV NS3/4A protease and induces conformational changes in the protease. BMS-986144 reduces time-dependent CYP3A4 inhibition, exhibits hepatic microsomal metabolic stability, and undergoes oxidation of the macrocyclic linker chain. BMS-986144 can be used in studies related to hepatitis C virus infection.

6-Deoxyparomomycin is found in the strain of Streptomyces rimosus forma paromomycinus with antibacterial activity.

β-Aflatrem is an insecticide metabolite from the sclerotium of Aspergillus flavus that exhibits significant activity against the corn borer H. zea.

Griseolutein B shows activitiy against Gram-positive and negative bacteria.

Cystothiazole A has antifungal activity. Cystothiazole A can inhibit candida albicans, saccharomyces cerevisiae and aspergillus smoke with MIC values of 0.4 μg/mL, 0.1 μg/mL and 1.6 μg/mL, respectively. Cystothiazole A also inhibits human tumor cell, such as HPT-116 and K562 cells with MIC values of 130 ng/mL and 110 ng/mL, respectively. Cystothiazole A has no anti-bacterial effect.

Chlorquinaldol (Standard) is the analytical standard of Chlorquinaldol. This product is intended for research and analytical applications. Chlorquinaldol (Chloquinan) is an antibacterial agent with the potential use in topical skin conditions and vaginal infections. Chlorquinaldol is a β-catenin/TCF4 inhibitor, showing anti-proliferation, anti-migration, and apoptosis-inducing activity in cancer cells.

Asperenone is an inhibitor of 15-lipoxygenase (15-LOX) with an IC₅₀ value of 0.3 mM. It is also an inhibitor of platelet aggregation, with an IC₅₀ value of 0.23 mM. Additionally, Asperenone has antifungal activity and can inhibit the growth of pathogenic fungi Ophiostoma crassivaginatum and O. piliferum. Asperenone can be used in the research of cardiovascular diseases and anti-infection fields.

RH12 is a dual inhibitor for SARS-CoV-2 related RNA-dependent RNA polymerase (RdRp, IC₅₀ is 4.42 nM) and human transmembrane serine protease 2 (TMPRSS2, IC₅₀ is 4.2 nM). RH12 exhibits antiviral efficacy. RH12 inhibits viral replication and absorption, and exhibits a 90.5% virucidal effects on Vero-E6 cells. RH12 inhibits cell viability of Calu-3 with an IC₅₀ of 17.5 nM.

XZ426 (Standard) is the analytical standard of XZ426 (HY-108818). This product is intended for research and analytical applications. XZ426 is a potent integrase strand transfer inhibitor with anti- HIV activity.

FIT-039 (Standard) is the analytical standard of FIT-039. This product is intended for research and analytical applications. FIT-039 is a selective, ATP-competitive and orally active CDK9 inhibitor with an IC50 of 5.8 μM for CKD9/cyclin T1. FIT-039 does not inhibit other CDKs and other kinases. FIT-039 inhibits replication of HSV-1 (IC50 of 0.69 μM), HSV-2, human adenovirus, and human CMV. FIT-039 is a promising antiviral agent for inhibiting drug-resistant HSVs and other DNA viruses.

SDH-IN-16 (compound 5aa) is a potent inhibitor of Succinate Dehydrogenase, with the IC₅₀ of 1.62 μM. SDH-IN-16 displays a broad spectrum of antifungal activity against F. graminearum, B. cinerea, S. sclerotiorum, and R. solani, with the corresponding EC₅₀ values of 0.12, 4.48, 0.33, and 0.15 μg/mL, respectively.

CGP-75355 is an inhibitor of HIV-1 protease with IC₅₀ of 26 nM. CGP-75355 is a bis(L-tert-leucine) derivative.

Kynapcin-28 can non-competitively inhibit the activity of prolyl endopeptidase (PEP) with an IC₅₀ of 76.80 μM. Kynapcin-28 has a little inhibitory effect on other serine proteases.