72-80-0
72-80-0
Chemical Structure
Chlorquinaldol
Synonym(s): Chloquinan
- CAS No.: 72-80-0
- Formula:C10H7Cl2NO
- Molecular Weight:228.08
IUPAC Name: 5,7-dichloro-2-methylquinolin-8-ol
InChIKey: GPTXWRGISTZRIO-UHFFFAOYSA-N
SMILES: OC1=C2N=C(C)C=CC2=C(Cl)C=C1Cl
Biological Activity: Chlorquinaldol (Chloquinan) is an antibacterial agent with the potential use in topical skin conditions and vaginal infections. Chlorquinaldol is a β-catenin/TCF4 inhibitor, showing anti-proliferation, anti-migration, and apoptosis-inducing activity in cancer cells[1][2].
| Cat. No. | 상품명 | Purity | 제품 설명 | Pricing | |||||||||||||||||||
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Chlorquinaldol | 99.81% | Chlorquinaldol (Chloquinan) is an antibacterial agent with the potential use in topical skin conditions and vaginal infections. Chlorquinaldol is a β-catenin/TCF4 inhibitor, showing anti-proliferation, anti-migration, and apoptosis-inducing activity in cancer cells. | ||||||||||||||||||||
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Chlorquinaldol (Standard) | ≥98% | Chlorquinaldol (Standard) is the analytical standard of Chlorquinaldol. This product is intended for research and analytical applications. Chlorquinaldol (Chloquinan) is an antibacterial agent with the potential use in topical skin conditions and vaginal infections. Chlorquinaldol is a β-catenin/TCF4 inhibitor, showing anti-proliferation, anti-migration, and apoptosis-inducing activity in cancer cells. | ||||||||||||||||||||
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Clioquinol | 99.84% | Clioquinol (Iodochlorhydroxyquin) is a topical antifungal agent with anticancer activity. Clioquinol acts as an oral antimicrobial agent for the research of diarrhea and skin infections. Antibiotic. Clioquinol is a chelator that binds to Zn2+ and Cu2+ with a greater affinity than it binds to Ca2+ and Mg2+. Clioquinol freely crosses the blood-brain barrier. Clioquinol can be used for the study of Alzheimer's disease. | ||||||||||||||||||||
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NU1025 | 98.05% | NU1025 is a potent PARP inhibitor with an IC50 of 400 nM and a Ki of 48 nM. NU1025 potentiates the cytotoxicity of ionizing radiation and anticancer agents. NU1025 has anti-cancer and neuroprotective activity. | ||||||||||||||||||||
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Tilbroquinol | 98.02% | Tilbroquinol is an orally active halogenated hydroxyquinoline antiprotozoal agent, mainly used for anti-amoebic infections. Tilbroquinol targets intestinal protozoa and Entamoeba histolytica to eliminate parasites in the intestinal lumen. Tilbroquinol can be used in research related to intestinal infections, intestinal amoebiasis and hepatic amoebiasis. | ||||||||||||||||||||
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4,7-Dichloroquinoline | 99.95% | 4,7-Dichloroquinoline is a dichloro-substituted quinoline that can be used for the synthesis of other active compounds. | ||||||||||||||||||||
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4,7-Dichloroquinoline-15N | 4,7-Dichloroquinoline-15N is the 15N labeled 4,7-Dichloroquinoline (HY-59243). 4,7-Dichloroquinoline is a dichloro-substituted quinoline that can be used for the synthesis of other active compounds. | |||||||||||||||||||||
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Chloroxine (Standard) | ≥98% | Chloroxine (Standard) is the analytical standard of Chloroxine. This product is intended for research and analytical applications. Chloroxine is one of the important 8-hydroxyquinoline derivative. Chloroxine has effective antibacterial, antifungal, antiprotozoal and antiamoebic activities, especially used in treating the intestinal amebiasis. Chloroxine is also used in the treatment of dandruff and seborrheic dermatitis of the scalp. | ||||||||||||||||||||
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Cloxiquine | 99.94% | Cloxiquine (5-Chloro-8-quinolinol) is an antibacterial, antifungal and antiamoebic agent. Cloxiquine can be used for the research of tuberculosis and dermatoses. Cloxiquine suppresses the growth and metastasis of melanoma cells through activation of PPARγ. | ||||||||||||||||||||
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4-Chloroquinaldine | 4-Chloroquinaldine is an antibacterial agent. 4-Chloroquinaldine is an intermediate. | |||||||||||||||||||||
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Broquinaldol | 99.70% | Broquinaldol, a brominated quinoline, is a potent antistaphylococcal agent. Broquinaldol is also a Mn(II) ionophore that can be used to synthesize metalloantibiotic. | ||||||||||||||||||||
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4-Chloroquinolin-8-ol | 4-Chloroquinolin-8-ol (compound 1) is an Alq3-derived aluminum ligand. Alq3 is an organometallic molecule widely used as electron transport layer and light-emitting layer in organic LEDs, and also as a host for fluorescent and phosphorescent dyes. | |||||||||||||||||||||
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References
- [1]. Bortolin M, et al. In vitro Antimicrobial Activity of Chlorquinaldol against Microorganisms Responsible for Skin and Soft Tissue Infections: Comparative Evaluation with Gentamicin and Fusidic Acid. Front Microbiol. 2017 Jun 8;8:1039. [Content Brief]
- [2]. Wang L, et al. Chlorquinaldol targets the β-catenin and T-cell factor 4 complex and exerts anti-colorectal cancer activity. Pharmacol Res. 2020 Sep;159:104955. [Content Brief]
