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ADC Linkers Related Products (527)
Related Products (527)
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Alkyne-Val-Cit-PAB-PNP
0 ImagesCat. No.: HY-W591286CAS No.: 2748039-77-0Alkyne-Val-Cit-PAB-PNP is a cleavable ADC linker.
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Chemical phosphorylation amidite
0 ImagesCat. No.: HY-151747CAS No.: 202284-84-2Chemical phosphorylation amidite is a click chemical class ADC linker. Click chemistry has good biological orthogonality characteristics: biocompatible, fast and highly specific in the biological environment, and has great application potential in the binding between nucleic acids, lipids, proteins and other molecules.
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4-Pentynoyl-Val-Ala-PAB
0 ImagesCat. No.: HY-151739CAS No.: 1956294-75-94-Pentynoyl-Val-Ala-PAB is a click chemical class ADC linker. Click chemistry has good biological orthogonality characteristics: biocompatible, fast and highly specific in the biological environment, and has great application potential in the binding between nucleic acids, lipids, proteins and other molecules.
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H-L-Dbu(N3)-OH hydrochloride
0 ImagesCat. No.: HY-151785AH-L-Dbu(N3)-OH is a click chemistry reagent containing an azide group. Click chemistry has great potential for use in binding between nucleic acids, lipids, proteins, and other molecules, and has been used in many research fields because of its beneficial characteristics, including high yield, high specificity, and simplicity. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
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DACN(Tos) hydrochloride
0 ImagesCat. No.: HY-151795CAS No.: 2331322-18-8DACN(Tos) hydrochloride is a click chemistry reagent containing a cycloalkyne group. The alkyne moiety within the ring has a unique bent structure and high reactivity toward cycloaddition reactions, such strain-promoted azide-alkyne cycloadditions (SPAAC) by using cycloalkynes. DACNs possesses high thermal and chemical stability along with comparable click reactivity. DACN(Tos) hydrochloride can be used for the research of molecular conjugation.
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Mal-amido-PEG8-val-gly
0 ImagesCat. No.: HY-W190924CAS No.: 2353409-54-6Mal-amido-PEG8-Val-Gly is an ADC linker containing a maleimide group.
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DiAz-Pen-LacNAc-Oxa
0 ImagesCat. No.: HY-Y2042DiAz-Pen-LacNAc-Oxa is an ADC linker. DiAz-Pen-LacNAc-Oxa contains a disaccharide linker for glycosite-specific glycosylation coupling and a symmetrical diazid linker for subsequent click reactions. DiAz-Pen-LacNAc-Oxa can serve as a ribonucleic acid raw material and reaction substrate for glycosyltransferases in ADC-related studies involving nucleotide sugars.
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Azido-PEG4-Ala-Ala-Asn(Trt)-PAB
0 ImagesCat. No.: HY-141152CAS No.: 2055042-67-4Azido-PEG4-Ala-Ala-Asn(Trt)-PAB is a cleavable ADC linker.
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2-Aminoethyl-mono-amide-DOTA-tris(tBu ester) (Standard)
0 ImagesCat. No.: HY-100138RCAS No.: 173308-19-52-Aminoethyl-mono-amide-DOTA-tris(tBu ester) (Standard) is the analytical standard of 2-Aminoethyl-mono-amide-DOTA-tris(tBu ester) (HY-100138). This product is intended for research and analytical applications. 2-Aminoethyl-mono-amide-DOTA-tris(tBu ester) is a metal chelator precursor containing a DOTA macrocyclic structure. DOTA can form highly stable complexes with metal ions (such as 68Ga, 177Lu) through four nitrogen atoms and four carboxylic acid groups to mediate targeted delivery of radionuclides. The tert-butyl ester group (tBu ester) of 2-Aminoethyl-mono-amide-DOTA-tris(tBu ester) also protects the carboxylic acid group during synthesis, and forms a free carboxyl group after deprotection reaction for coupling with targeting molecules (such as antibodies, peptides). 2-Aminoethyl-mono-amide-DOTA-tris(tBu ester) may be combined with tumor pre-targeting systems through bioorthogonal reactions (such as reverse electron demand Diels-Alder reaction) to study radioactive imaging or therapy of tumor tissues, and is mainly used in tumor pre-targeting research in the field of nuclear medicine.
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DecarboxyBiotin-Alkyne
0 ImagesCat. No.: HY-151864CAS No.: 887915-53-9DecarboxyBiotin-Alkyne is a click chemistry reagent containing an azide group. Click chemistry has great potential for use in binding between nucleic acids, lipids, proteins, and other molecules, and has been used in many research fields because of its beneficial characteristics, including high yield, high specificity, and simplicity.
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Fmoc-L-Lys(Pentynoyl-DIM)-OH
0 ImagesCat. No.: HY-151786CAS No.: 2408993-33-7Fmoc-L-Lys(Pentynoyl-DIM)-OH is a click chemistry reagent containing an azide. Fmoc-L-Lys(Pentynoyl-DIM)-OH can be used as a SPPS building block for the “helping hand” strategy for purification of highly insoluble peptides. Solubilizing residues are attached to the Lys side-chains using Click-chemistry. The solubilizing tag can be removed with 1M hydrazine or hydroxylamine solution. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
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N3-L-Lys(Fmoc)-OH
0 ImagesCat. No.: HY-151843CAS No.: 473430-12-5N3-L-Lys(Fmoc)-OH is a non-natural amino acid building block specially designed for solid-phase peptide synthesis and click chemistry. N3-L-Lys(Fmoc)-OH can be used as a linker for ADC (antibody-drug conjugate) or for the development of targeting peptides.
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Boc-L-Tyr(PEG(3)-N3)-OH
0 ImagesCat. No.: HY-151718CAS No.: 1831059-64-3Boc-L-Tyr(PEG(3)-N3)-OH is a click chemistry agent containing azide. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
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cBu-Cit-PAB
0 ImagesCat. No.: HY-177503CAS No.: 1799660-01-7cBu-Cit-PAB (Compound 13) is a key intermediate of ADC linker. cBu-Cit-PAB can be used for synthesis of antibody-drug conjugates (ADCs).
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(2R,4S)-H-D-Pro(4-N3)-OH hydrochloride
0 ImagesCat. No.: HY-151760A(2R,4S)-H-D-Pro(4-N3)-OH hydrochloride is a click chemistry reagent containing an azide group. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
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Mm-C3-OSu
0 ImagesCat. No.: HY-176893CAS No.: 2410723-30-5Mm-C3-OSu (Methyl Maleate-C3-N-Hydroxysuccinimide Ester) is a structurally defined linker intermediate with a cis-configured methyl maleate (Mm) core and a C3 alkyl chain terminated by an N-hydroxysuccinimide (OSu) reactive group, designed for constructing stable antibody-drug conjugates (ADCs).
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DACN(Tos,Mal)
0 ImagesCat. No.: HY-151771CAS No.: 2411082-28-3DACN(Tos,Mal) is a click chemistry reagent containing an azide. DACN(Tos,Mal) possess high thermal and chemical stability along with comparable click reactivity.
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NH2-PEG6-Val-Cit-PAB-OH
0 ImagesCat. No.: HY-W800620CAS No.: 2055024-60-5NH2-PEG6-Val-Cit-PAB-OH is a cleavable ADC linker featuring a primary amine, a hydrophilic PEG spacer, a Val-Cit dipeptide, and a PAB group. The benzylic alcohol on the PAB can be used to attach with reactive groups such as PNP for conjugation with drug payloads. The primary amine is free to perform a wide variety of reactions such as coupling with carboxylic acids, reductive aminations with ketones or aldehydes, or other more specialized uses such as in SNAr reactions or heterocyclic chemistry. The Val-Cit dipeptide is cleaved by cellular proteases within the cell to allow for efficient payload delivery via an elimination mechanism within the PAB structure.
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SCO-PEG7-Maleimide
0 ImagesCat. No.: HY-156321CAS No.: 2143968-81-2SCO-PEG7-Maleimide is a cleavable ADC Linker containing 3 PEG units. SCO-PEG7-Maleimide can be used as a copper-free click chemical reagent for catalyst-free click reactions. Its maleimide group (-Maleimide) degrades in aqueous media and has been used in drug delivery studies.
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BCN-exo-PEG8-NHS
0 ImagesCat. No.: HY-156324BCN-exo-PEG8-NHS is an ADC Linker containing 8 PEG units. BCN-exo-PEG8-NHS contains the lyophilic bidentate macrocyclic ligand BCN, which allows for further synthesis of macrocyclic complexes. In click chemistry, BCN reacts with molecules containing azide groups to form stable triazoles in the absence of catalysts.
