Androgen Receptor
Androgen receptor (AR) is a type of nuclear receptor that is activated by binding of either of the androgenic hormones testosterone or dihydrotestosterone in the cytoplasm and then translocating into the nucleus. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. The androgen receptor is most closely related to the progesterone receptor, and progestins in higher dosages can block the androgen receptor. The main function of the androgen receptor is as a DNA-binding transcription factor that regulates gene expression. Androgen regulated genes are critical for the development and maintenance of the male sexual phenotype. Mutations in this gene are also associated with complete androgen insensitivity (CAIS).
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Androgen Receptor Inhibitors
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Androgen Receptor Agonists
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Androgen Receptor Antagonists
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Androgen Receptor Ligands
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Androgen Receptor Proteins
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Androgen Receptor Related Products (483)
Related Products (483)
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Recombinant Proteins (1)
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Antibodies (2)
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Androgen receptor modulator 3
0 ImagesCat. No.: HY-171049CAS No.: 1018971-95-3Androgen receptor modulator 3 is a selective modulator for androgen receptor that can be used for research of sarcopenia.
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Spironolactone-d3-1
0 ImagesCat. No.: HY-B0561S2Synonyms: SC9420-d3-1Spironolactone-d3-1 is deuterium labeled Spironolactone. Spironolactone (SC9420) is an orally active aldosterone mineralocorticoid receptor antagonist with an IC50 of 24 nM. Spironolactone is also a potent antagonist of androgen receptor with an IC50 of 77 nM. Spironolactone promotes autophagy in podocytes.
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Topilutamide (Standard)
0 ImagesSynonyms: BP766 (Standard); Fluridil (Standard)Topilutamide (Standard) is the analytical standard of Topilutamide. This product is intended for research and analytical applications. Topilutamide is a topical nonsteroidal antiandrogen (NSAA).
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Cyproterone acetate-d3
0 ImagesCat. No.: HY-13604SCAS No.: 2376035-90-2Cyproterone acetate-d3 is deuterium labeled Cyproterone acetate. Cyproterone acetate is an anti-androgen (IC50=7.1 nM) and progestogen synthetic steroid. Cyproterone acetate has affinity with progesteron and with glucocorticoidal receptors.
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(rel)-BMS-641988
0 ImagesCat. No.: HY-13607ACAS No.: 573738-99-5(rel)-BMS-641988 is a relative configuration of BMS-641988. BMS-641988 is a potent nonsteroidal androgen receptor antagonist. BMS-641988 has the potential for the research of prostate cancer.
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SJH1-62B
0 ImagesCat. No.: HY-162241SJH1-62B is a selective Androgen receptor PROTAC degrader. SJH1-62B induces ubiquitination and degradation of the androgen receptor. SJH1-62B can be used for the research of prostate cancer.
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Ac-PPPHPHARIK-NH2
0 ImagesCat. No.: HY-P2413CAS No.: 957791-38-7Ac-PPPHPHARIK-NH2 (compound S1) is a compound that inhibits the interaction between androgen receptor and Src. It can inhibit the binding of androgen or estrogen-induced receptor and Src in cancer cells, as well as the activation of related signaling pathways, and can also inhibit cell cycle progression and tumor growth.
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AR ligand-49
0 ImagesCat. No.: HY-179605AR ligand-49 (Compound 4q) is a dual ligand for the adenosine A2A receptor (A2AAR) and the A3 receptor (A3AR). Its Ki values are 15 and 4.5 nM respectively. AR ligand-49 exhibits reverse agonistic activity at hA2AAR and antagonistic activity at hA3AR. AR ligand-49 can be used for the study of the design and development of adenosine receptor ligands.
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RU 56279
0 ImagesCat. No.: HY-77833CAS No.: 143782-20-1RU 56279 is an androgen receptor (AR) antagonist with strong and systemic anti-androgenic activity. RU 56279 is also a common, potent and long-lasting anti-androgen metabolite of RU 56187 (HY-117486) and RU 58841 (HY-10561) in vivo. RU 56279 can be used as an AR ligand to construct an AR-targeted prodrug system for the study of AR-positive tumor cells.
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Androgen receptor-IN-7
0 ImagesCat. No.: HY-179050CAS No.: 401580-43-6Androgen receptor-IN-7 is a potent androgen receptor (AR) inhibitor. Androgen receptor-IN-7 exhibits potent anticancer activity against PC-3 cells (IC50 =370.37 nM) and LNCaP cells via both AR-dependent and AR-independent pathways. Androgen receptor-IN-7 induces ROS production in PC-3 cells. Androgen receptor-IN-7 can be used for prostate cancer research.
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WNY0824
0 ImagesCat. No.: HY-143471CAS No.: 2412707-81-2Synonyms: PLK1/BRD4-IN-1WNY0824 (PLK1/BRD4-IN-1) is an orally active dual inhibitor of PLK1 and BET protein families, with IC50 values of 22, 402.5, 150.7, 103.9, and 311.9 nmol/L for PLK1, BRD2, BRD3, BRD4, and BRDT, respectively. WNY0824 induces cell cycle arrest and apoptosis by inhibiting AR- and MYC-mediated transcriptional processes. In addition, WNY0824 also inhibits tumor growth in Enzalutamide (HY-70002) resistant CRPC xenograft tumor models.
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Dimethomorph-d8
0 ImagesCat. No.: HY-B0846SCAS No.: 1346606-71-0Dimethomorph-d8 is the deuterium labeled Dimethomorph. Dimethomorph is a fungicide belongs to the fungicide group of sterol biosynthesis inhibitor. Dimethomorph can inhibit fungal cell wall formation. Dimethomorph also inhibits androgen receptor (AR) activity in MDA-kb2 cells with an IC20 of 0.263 μM.
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Androgen receptor antagonist 11
0 ImagesCat. No.: HY-168141CAS No.: 2719816-32-5Androgen receptor antagonist 11 (compund N29) is a derivative of the androgen receptor (AR) antagonist M17-B15, and is a selective and orally active AR antagonist (IC50=18 nM)..
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Dehydroisoandrosterone 3-acetate (Standard)
0 ImagesSynonyms: Dehydroepiandrosterone 3-acetate (Standard); DHEA acetate (Standard)Dehydroisoandrosterone 3-acetate (Standard) is the analytical standard of Dehydroisoandrosterone 3-acetate. This product is intended for research and analytical applications. Dehydroepiandrosterone 3-acetate is a testosterone/estrogen precursor and known modulator of vertebrate aggression.
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MK-4541
0 ImagesCat. No.: HY-125065CAS No.: 796885-38-6MK-4541 is an orally active and selective androgen receptor (AR) modulator. MK-4541 acts as an antagonist to inhibit 5α-reductase. MK-4541 inhibits proliferation and induces apoptosis in AR positive prostate cancer cells. MK-4541 significantly inhibited the growth of R3327-G prostate tumors in xenograft mouse model.
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AR antagonist 18
0 ImagesCat. No.: HY-187369CAS No.: 3084436-73-4AR antagonist 18 is a selective androgen receptor antagonist with an IC50 of 20.6 nM. AR antagonist 18 exerts AR transcriptional inhibitory effects by interacting with AR residues Phe765 and Trp742 via conformational flexibility. AR antagonist 18 acts as a hair growth inducer, and exhibits low systemic exposure and reduced distribution to male reproductive organs in a mouse model of hair growth. AR antagonist 18 can be used for research on androgenetic alopecia.
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VPC13163
0 ImagesVPC13163 is a potent androgen receptor (AR) BF3 inhibitor with an IC50 of 0.31 µM. VPC13163 has anticancer effects.
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Acetyl-ACTH (3-24) (human, bovine, rat)
0 ImagesCat. No.: HY-P4782CAS No.: 1815617-99-2Acetyl-ACTH (3-24) (human, bovine, rat) is a fragment of proopiomelanocortin (POMC) peptide. POMC peptides such as adrenocorticotrophin (ACTH), which is the precursor of α-MSH, is also an agonist at the MC-1 receptor.
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MK-3984
0 ImagesCat. No.: HY-111246CAS No.: 871325-55-2MK-3984 is a selective androgen receptor modulator (SARM). MK-3984 can be used for the research of muscle wasting associated with cancer.
