Calcium Channel
Ca2+ channels; Ca channels
Calcium channel is an ion channel which displays selective permeability to calcium ions. It is sometimes synonymous as voltage-dependent calcium channel, although there are also ligand-gated calcium channels. Voltage-gated calcium (CaV) channels catalyse rapid, highly selective influx of Ca2+ into cells despite a 70-fold higher extracellular concentration of Na+. Some calcium channel blockers have the added benefit of slowing your heart rate, which can further reduce blood pressure, relieve chest pain (angina) and control an irregular heartbeat.
Calcium Channel Isoform Specific Products
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Calcium Channel Inhibitors
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Calcium Channel Agonists
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Calcium Channel Antagonists
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Calcium Channel Activators
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Calcium Channel Modulators
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Calcium Channel Chemical
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Calcium Channel Inducers
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Calcium Channel Controls
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Calcium Channel Ligands
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Calcium Channel Related Products (1237)
Related Products (1237)
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Antibodies (29)
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Related Compound Screening Libraries (1)
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Calcium Channel Isoform Comparison
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Clonixin (Standard)
0 ImagesSynonyms: SCH-10304 (Standard)Clonixin (SCH-10304) (Standard) is the analytical standard of Clonixin. This product is intended for research and analytical applications. Clonixin is an orally active non-steroidal anti-inflammatory agent (NSAID) that inhibits COX synthesis. Clonixin acts as a voltage-gated L-type calcium channel blocker, exerts vasodilatory effects by antagonizing Ca2+ in vascular smooth muscle. Clonixin inhibits TGF-β, reduces lung coefficient, immune cell infiltration level, oxidative stress response, airway resistance, hydroxyproline content and collagen deposition. Clonixin can be used in research related to inflammation such as idiopathic pulmonary fibrosis and moderate to severe pain.
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Isradipine (Standard)
0 ImagesSynonyms: PN 200-110 (Standard)Isradipine (Standard) is the analytical standard of Isradipine. This product is intended for research and analytical applications. Isradipine (PN 200-110) is an orally active L-type calcium channel blocker. Isradipine, as a powerful peripheral vasodilator, is a dihydropyridine calcium antagonist with selective actions on the heart as well as the peripheral circulation. Isradipine is a potentially viable neuroprotective agent for Parkinson's disease.
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Norverapamil-d6 hydrochloride
0 ImagesCat. No.: HY-W699430CAS No.: 1329651-21-9Synonyms: (±)-Norverapamil-d6 hydrochloride; D591-d6 hydrochlorideNorverapamil-d6 ((±)-Norverapamil-d6) hydrochloride is deuterium labeled Norverapamil (hydrochloride). Norverapamil hydrochloride ((±)-Norverapamil hydrochloride), an N-demethylated metabolite of Verapamil, is a L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor.
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Ranolazine (Standard)
0 ImagesCat. No.: HY-B0280RCAS No.: 95635-55-5Synonyms: CVT 303 (Standard); RS 43285-003 (Standard)Ranolazine (Standard) is the analytical standard of Ranolazine. This product is intended for research and analytical applications. Ranolazine (CVT 303) is an anti-angina drug that achieves its effects by inhibiting the late phase of inward sodium current (INa and IKr with IC50 values of 6 μM and 12 μM, respectively) without affecting heart rate or blood pressure (BP). Ranolazine is also a partial fatty acid oxidation (FAO) inhibitor. Antianginal agent.
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Sadopine
0 ImagesCat. No.: HY-120411CAS No.: 111127-62-9Sadopine is an allosteric modulator for dihydropyridine receptor ((-)Sadopine as positive allosteric modulator and (+)Sadopine as negative allosteric modulator). Sadopine interacts with dihydropyridine (DHP)-sensitive L-type calcium channels.
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Ro 18-3981
0 ImagesCat. No.: HY-117055CAS No.: 103295-92-7Ro 18-3981 is a dihydropyridine that inhibits cardiac Ca2+ channels. Ro 18-3981 shows higher inhibitory activity when the cell membrane is in a depolarized state (Vh=-20 mV: IC50=2.3 nM; Vh=-50 mV: IC50=100 nM).
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BODIPY FL Thapsigargin
0 ImagesCat. No.: HY-D1608CAS No.: 216571-99-2BODIPY FL Thapsigargin is a potent green fluorescent dye. BODIPY FL Thapsigargin inhibits intracellular SERCA-type Ca2+ pumps present in the sarcoplasmic/endoplasmic reticulum. BODIPY FL Thapsigargin used for investigation of thapsigargin binding sites in live cells.
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PDDHV
0 ImagesCat. No.: HY-130358CAS No.: 179469-40-0PDDHV is a calcium absorption inducer and may achieve 45Ca2+ influx by stimulating vanillic acid receptor VR1. PDDHV induces 45Ca2+ uptake (EC50: 70 nM) in rat dorsal root ganglion neurons (expressing native vanilloid receptors) and calcium mobilization (EC50: 125 nM) in VR1-transfected CHO cells. PDDHV also inhibits [3H]-resiniferatoxin (RTX) binding to the dorsal root ganglion membrane in rats.
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Diltiazem-d6 hydrochloride
0 ImagesCat. No.: HY-14656S2CAS No.: 1309283-34-8Synonyms: CRD-401-d6 hydrochlorideDiltiazem-d6 (hydrochloride) (CRD-401-d6 (hydrochloride)) is deuterium labeled Diltiazem (hydrochloride). Diltiazem hydrochloride is a Ca2+ influx inhibitor (slow channel blocker or calcium antagonist).
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Carboxyamidotriazole Orotate (Standard)
0 ImagesSynonyms: L-651582 Orotate (Standard); CAI Orotate (Standard)Carboxyamidotriazole (Orotate) (Standard) is the analytical standard of Carboxyamidotriazole (Orotate). This product is intended for research and analytical applications. Carboxyamidotriazole Orotate (L-651582 Orotate) is the orotate salt form of Carboxyamidotriazole (CAI), an orally bioavailable signal transduction inhibitor. Carboxyamidotriazole Orotate is a cytostatic inhibitor of nonvoltage-operated calcium channels and calcium channel-mediated signaling pathways. Carboxyamidotriazole Orotate shows anti-tumor, anti-inflammatory and antiangiogenic effects.
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SC42619 free base
0 ImagesCat. No.: HY-123200CAS No.: 107534-95-2SC42619 free base is a selective platelet thrombin receptor (thrombin receptor) antagonist. SC42619 free base inhibits thrombin-induced platelet aggregation, secretion, calcium influx, and phosphatidic acid phosphorylation, as well as trypsin-induced platelet aggregation. SC42619 free base reduces the content of individual platelets. SC42619 free base inhibits prostacyclin (PGI2) synthesis in endothelial cells. SC42619 free base can be used for the research of hematological diseases.
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Bupivacaine (Standard)
0 ImagesBupivacaine (Standard) is the analytical standard of Bupivacaine. This product is intended for research and analytical applications. Bupivacaine is a NMDA receptor inhibitor. Bupivacaine can block sodium, L-calcium, and potassium channels.Bupivacaine potently blocks SCN5A channels with the IC50 of 69.5 μM. Bupivacaine can be used for the research of chronic pain.
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Nisoldipine-d7
0 ImagesCat. No.: HY-17402S2CAS No.: 1189718-34-0Nisoldipine-d7 (BAY-k 5552-d7) is the deuterium labeled Nisoldipine. Nisoldipine(BAY-k 5552) is a calcium channel blocker belonging to the dihydropyridines class, specific for L-type Cav1.2 with IC50 of 10 nM.
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Liguzinediol
0 ImagesCat. No.: HY-121864CAS No.: 909708-65-2Liguzinediol is a protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A) inhibitor that enhances the activity of sarcoplasmic reticulum Ca2+-ATPase (SERCA2a). Liguzinediol reduces the dephosphorylation level of phospholamban and increases the phosphorylation levels of phospholamban at serine-16 and threonine-17 sites. Liguzinediol exerts positive inotropic effects in rat hearts both in vivo and in vitro, and reverses caffeine-induced decrease in myocardial contractility in isolated rat hearts. Liguzinediol can be used for the research of heart failure.
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Dronedarone-d6
0 ImagesCat. No.: HY-A0016S3CAS No.: 1132693-87-8Synonyms: SR 33589-d6Dronedarone-d6 (SR 33589-d6) is deuterium labeled Dronedarone. Dronedarone (SR 33589), a derivative of amiodarone (HY-14187), is a class III antiarrhythmic agent for the study of atrial fibrillation (AF) and atrial flutter. Dronedarone is a potent blocker of multiple ion currents, including potassium current, sodium current, and L-type calcium current, and exhibits antiadrenergic effects by noncompetitive binding to β-adrenergic receptors. Dronedarone is a substrate for and a moderate inhibitor of CYP3A4.
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Urolithin C (Standard)
0 ImagesCat. No.: HY-135897RCAS No.: 165393-06-6Urolithin C (Standard) is the analytical standard of Urolithin C. This product is intended for research and analytical applications. Urolithin C, a gut-microbial metabolite of Ellagic acid, is a glucose-dependent activator of insulin secretion. Urolithin C is a L-type Ca2+ channel opener and enhances Ca2+ influx. Urolithin C induces cell apoptosis through a mitochondria-mediated pathway and also stimulates reactive oxygen species (ROS) formation.
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TGR5 Receptor Agonist (Standard)
0 ImagesSynonyms: CCDC (Standard)TGR5 Receptor Agonist (Standard) is the analytical standard of TGR5 Receptor Agonist. This product is intended for research and analytical applications. TGR5 Receptor Agonist (CCDC), a potent Takeda G protein-coupled receptor 5 (TGR5; GPCR19) agonist, shows improved potency in the U2-OS cells and melanophore cells with pEC50s of 6.8 and 7.5, respectively. TGR5 Receptor Agonist can induce peripheral and central hypersensitivity to bladder distension in mice, and increase intracellular Ca2+ concentration. TGR5 Receptor Agonist can also reduces food intake and improves insulin responsiveness, in diet-induced obese mice. TGR5 Receptor Agonist can be used to research diabetes, bladder hypersensitivity and anti-obesity.
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SB-237376 free base
0 ImagesCat. No.: HY-108163CAS No.: 179258-59-4SB-237376 (free base) is a potassium and calcium channel blocker. SB-237376 (free base) can inhibit the rapidly activating delayed rectifier potassium current I(Kr) (IC50 is 0.42 μM), and at high concentrations, it blocks the L-type calcium current I(Ca,L). In the rabbit ventricular model, SB-237376 (free base) can induce early afterdepolarizations (EADs) at a concentration of 3 µM. Compared to other IKr inhibitors such as dl-sotalol, SB-237376 has a lower proarrhythmic risk. SB-237376 (free base) holds potential for research in the field of arrhythmia-related diseases.
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Rp-8-Br-cGMPS
0 ImagesCat. No.: HY-135110ACAS No.: 150418-07-8Synonyms: Rp-8-bromo-Cyclic GMPS
