Drug Intermediate
Drug Iintermediate
Drug intermediates are used as raw materials for the production of bulk drugs, or they can refer to a material produced during synthesis of an API that must undergo further molecular change or processing before it becomes an API. Drug intermediates are hygienically formulated using high grade raw materials and they are used in the pharmaceutical and cosmetic industry[1][2].
References:
- [1]. Ma HC, et al. Homochiral Covalent Organic Framework for Catalytic Asymmetric Synthesis of a Drug Intermediate. J Am Chem Soc. 2020 Jul 22;142(29):12574-12578. [Content Brief]
- [2]. Ramachary D B, et al. Development of pharmaceutical drugs, drug intermediates and ingredients by using direct organo‐click reactions[J]. 2008.
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Drug Intermediate Related Products (4718)
Related Products (4718)
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5-Methoxy-5-oxopentanoic acid
0 Images5-Methoxy-5-oxopentanoic acid is a natural metabolite in human urine. 5-Methoxy-5-oxopentanoic acid is a derivative of Glutaric acid (HY-W008820) and a chiral building block.
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3-Amino-6-chloropyridazine
0 Images3-Amino-6-chloropyridazine is a nitrogen-containing heterocyclic organic compound belonging to the pyridazine derivatives. 3-Amino-6-chloropyridazine has the basicity of amino groups and the nucleophilic substitution activity of chlorine atoms. 3-Amino-6-chloropyridazine can serve as an important intermediate for synthesizing some active compounds.
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3-Bromo-2-methylaniline
0 Images3-Bromo-2-methylaniline is an aromatic amine compound and aniline derivative that serves as a starting material and synthetic precursor. 3-Bromo-2-methylaniline acts as a starting material for the synthesis of 4-bromo-1H-indazole and racemic 3,9-dibromo-4,10-dimethyl-6H,12H-5,11-methanodibenzodiazocine. It also serves as a precursor for the regioselective bromination and subsequent deamination to synthesize 1,2-dibromo-3-methylbenzene.
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Boc-Phe-Gly-OH
0 ImagesBoc-Phe-Gly-OH is an N-Boc protected dipeptide, consisting of N-tert-butoxycarbonyl (Boc)-protected phenylalanine and glycine. Boc-Phe-Gly-OH serves as an intermediate in organic synthesis-related research.
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PAMAM Dendrimer G0.0 amine (20% in methanol)
0 ImagesCat. No.: HY-W157376CAS No.: 155773-72-1PAMAM Dendrimer G0.0 amine is a pore-forming channel antagonist, including anthrax toxin protective antigen 63 (PA63, IC50 = 231 nM) and C. botulinum C2 toxin subunit (C2IIa, IC50 = 940 nM). At concentrations of 10 and 20 µM, PAMAM Dendrimer G0.0 amine reduces C2 toxin-induced death in HeLa cells. Additionally, PAMAM Dendrimer G0.0 amine is a chelator of nickel. In complexes with polysulfone membrane-bound chitosan, PAMAM Dendrimer G0.0 amine selectively captures and stores carbon dioxide (CO2) in a gas-feed system. PAMAM Dendrimer G0.0 amine has been used in the synthesis of PAMAM Dendrimer G0.5 Carboxylate (CAS 339334-01-9) and PAMAM Dendrimer G1.0 Amine (CAS 142986-44-5). PAMAM Dendrimer G0.0 amine can be used in research related to infections, cancer, and drug delivery systems.
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Ammonium dihydrogen phosphate
0 ImagesAmmonium dihydrogen phosphate is an ammonium phosphate salt with both hydrogenation and dehydration properties. Ammonium dihydrogen phosphate decomposes to form phosphoric acid and ammonia upon heating, and serves as a main component of fertilizers. Ammonium dihydrogen phosphate promotes glycosidic bond cleavage, formation of dehydrated sugars and furans, biomass carbonization, hydrogen donor reactions, and lignin bond weakening. Ammonium dihydrogen phosphate selectively promotes the production of furfural and levoglucosenone during the pyrolysis of lignocellulosic biomass. Ammonium dihydrogen phosphate can be used as a nitrogen/phosphorus source and activator for the preparation of nitrogen-phosphorus co-doped activated carbon. Ammonium dihydrogen phosphate acts as a sucrose conversion catalyst in sustainable wood adhesive formulations. Ammonium dihydrogen phosphate is applicable to related research in various fields such as agriculture and electronics.
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1-Methyl-1H-indazol-5-amine
0 ImagesCat. No.: HY-69024CAS No.: 50593-24-31-Methyl-1H-indazol-5-amine is a drug intermediate that can be used for the synthesis of TRPM5 agonists.
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2,6-Diiodo-BODIPY 493/503
0 ImagesCat. No.: HY-W075603CAS No.: 1031443-55-6Synonyms: 2,6-Diiodo-Pyrromethene 5462,6-Diiodo-BODIPY 493/503 (2,6-Diiodo-Pyrromethene 546) is a 2,6-diiodo-substituted BODIPY intermediate that can be used to synthesize dual-organelle-targeted BODIPY-cyanostilbene fluorophores. 2,6-Diiodo-BODIPY 493/503 is applicable to research related to fluorescent dye synthesis.
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4-Biphenylsulfonyl chloride
0 Images4-Biphenylsulfonyl chloride is a synthetic intermediate that participates in the sulfonamide formation reaction to synthesize antiproliferative compounds. The derivatives of 4-Biphenylsulfonyl chloride inhibit human head and neck squamous cell carcinoma (HNSCC) cells by increasing PTEN expression and inhibiting the PI3K/Akt/mTOR pathway. 4-Biphenylsulfonyl chloride can be used in the development of anticancer drugs for HNSCC.
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4-Bromo-2,6-difluorobenzaldehyde
0 Images4-Bromo-2,6-difluorobenzaldehyde is a halogenated aromatic aldehyde and also a synthetic intermediate. 4-Bromo-2,6-difluorobenzaldehyde can be used for the synthesis of GDC-9545 (HY-109176), a selective estrogen receptor degrader and antagonist[1][2].
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6-Bromo-1H-indazole
0 Images6-Bromo-1H-indazole is an indazole derivative that serves as an intermediate for research related to organic synthesis. 6-Bromo-1H-indazole acts as a building block for the preparation of PI3Kδ inhibitors, and also functions as a synthetic intermediate for the preparation of colchicine site-targeted tubulin polymerization inhibitors[1][2].
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5-Bromo-1H-indole-2-carboxylic acid
0 Images5-Bromo-1H-indole-2-carboxylic acid is an indole-derived organic compound substituted with bromine and carboxyl groups. 5-Bromo-1H-indole-2-carboxylic serves as an important intermediate for the synthesis of other active compounds.
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(R)-Tetrahydrofuran-2-carboxylic acid
0 ImagesSynonyms: (R)-(+)-Tetrahydrofuran-2-carboxylic acid(R)-Tetrahydrofuran-2-carboxylic acid is a chiral building block for Faropenem (HY-A0035). Faropenem is a clinically effective non-natural β-lactam antibiotic.
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Tricyclohexylphosphonium tetrafluoroborate
0 ImagesTricyclohexylphosphonium tetrafluoroborate is an intermediate. Tricyclohexylphosphonium tetrafluoroborate can be used to synthesize anticancer agents (Compounds 7a, 7e). Tricyclohexylphosphonium tetrafluoroborate can be used in the research of leukemia, lung cancer, liver cancer, breast cancer and colon cancer.
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2-Bromo-4'-hydroxyacetophenone
0 Images2-Bromo-4'-hydroxyacetophenone is a PTP1B inhibitor with a Ki value of 42 μM. 2-Bromo-4'-hydroxyacetophenone is also an intermediate. 2-Bromo-4'-hydroxyacetophenone can be used in the synthesis of LXRα/β antagonists. 2-Bromo-4'-hydroxyacetophenone can be used in research on hematological diseases.
