155773-72-1
Chemical Structure
PAMAM Dendrimer G0.0 amine (20% in methanol)
- CAS No.: 155773-72-1
- Formula:C22H48N10O4
- Molecular Weight:516.68
IUPAC Name: 3,3',3'',3'''-(ethane-1,2-diylbis(azanetriyl))tetrakis(N-(2-aminoethyl)propanamide)
InChIKey: SENLDUJVTGGYIH-UHFFFAOYSA-N
SMILES: O=C(CCN(CCN(CCC(NCCN)=O)CCC(NCCN)=O)CCC(NCCN)=O)NCCN
Biological Activity: PAMAM Dendrimer G0.0 amine is a pore-forming channel antagonist, including anthrax toxin protective antigen 63 (PA63, IC50 = 231 nM) and C. botulinum C2 toxin subunit (C2IIa, IC50 = 940 nM). At concentrations of 10 and 20 µM, PAMAM Dendrimer G0.0 amine reduces C2 toxin-induced death in HeLa cells. Additionally, PAMAM Dendrimer G0.0 amine is a chelator of nickel. In complexes with polysulfone membrane-bound chitosan, PAMAM Dendrimer G0.0 amine selectively captures and stores carbon dioxide (CO2) in a gas-feed system. PAMAM Dendrimer G0.0 amine has been used in the synthesis of PAMAM Dendrimer G0.5 Carboxylate (CAS 339334-01-9) and PAMAM Dendrimer G1.0 Amine (CAS 142986-44-5). PAMAM Dendrimer G0.0 amine can be used in research related to infections, cancer, and drug delivery systems[1][2][3][4].
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PAMAM Dendrimer G0.0 amine (20% in methanol) | PAMAM Dendrimer G0.0 amine is a pore-forming channel antagonist, including anthrax toxin protective antigen 63 (PA63, IC50 = 231 nM) and C. botulinum C2 toxin subunit (C2IIa, IC50 = 940 nM). At concentrations of 10 and 20 µM, PAMAM Dendrimer G0.0 amine reduces C2 toxin-induced death in HeLa cells. Additionally, PAMAM Dendrimer G0.0 amine is a chelator of nickel. In complexes with polysulfone membrane-bound chitosan, PAMAM Dendrimer G0.0 amine selectively captures and stores carbon dioxide (CO2) in a gas-feed system. PAMAM Dendrimer G0.0 amine has been used in the synthesis of PAMAM Dendrimer G0.5 Carboxylate (CAS 339334-01-9) and PAMAM Dendrimer G1.0 Amine (CAS 142986-44-5). PAMAM Dendrimer G0.0 amine can be used in research related to infections, cancer, and drug delivery systems. | |||||||||||||||||||||
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References
- [1]. Heiden TC, et al. Developmental toxicity of low generation PAMAM dendrimers in zebrafish. Toxicol Appl Pharmacol. 2007 Nov 15;225(1):70-9. [Content Brief]
- [2]. Förstner P, et al. Cationic PAMAM dendrimers as pore-blocking binary toxin inhibitors. Biomacromolecules. 2014 Jul 14;15(7):2461-74. [Content Brief]
- [3]. Sohail I, et al. Polyamidoamine (PAMAM) dendrimers synthesis, characterization and adsorptive removal of nickel ions from aqueous solution[J]. Journal of Materials Research and Technology, 2020, 9(1): 498-506.
- [4]. Xiao Y, et al. Surface characterization, modification chemistry, and separation performance of polyimide and polyamidoamine dendrimer composite films. Langmuir. 2004 Sep 14;20(19):8230-8. [Content Brief]
