E3 Ligase Ligand-Linker Conjugates
E3 Ligase Ligand-Linker Conjugate, which is one part of Proteolysis Targeting Chimeric Molecules (PROTACs), incorporates a ligand for the E3 ubiquitin ligase and a linker. After linked to the ligand for target protein (such as JQ1 for BRD4 protein, Molibresib for BET protein), those conjugates can be used for constituting PROTACs that targetprotein for ubiquitination and degradation. Currently, several PROTACs have been found to show good biological activity by specifically targeting BET, estrogen receptor (ER), androgen receptor, etc. MedChemExpress (MCE) offers a wide range of high quality E3 Ligase Ligand-Linker Conjugates including von Hippel-Lindau (VHL) ligands, MDM2 ligands, Cereblon (CRBN) ligands and cIAP1 ligands conjugating with different linkers (PEGs, Alkyl-Chain, Alkyl/ether, etc.). It’s convenient and time-saving for designing and synthesizinga wide variety of novel PROTACs (ARV-825, dBET1,MT-802, etc.), which can expand the application of PROTACs in the treatment of cancer, autoimmunity, inflammation and other diseases.
E3 Ligase Ligand-Linker Conjugates Isoform Specific Products
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E3 Ligase Ligand-Linker Conjugates Related Products (1117)
Related Products (1117)
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Antibodies (1)
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E3 Ligase Ligand-Linker Conjugates Isoform Comparison
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(4R,5S)-Nutlin carboxylic acid-NHC2-PEG2-N3
0 ImagesCat. No.: HY-180924CAS No.: 3035510-04-1(4R,5S)-Nutlin carboxylic acid-NHC2-PEG2-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (4R,5S)-Nutlin carboxylic acid based MDM2 ligand and a linker used in PROTAC technology. (4R,5S)-Nutlin carboxylic acid-NHC2-PEG1-N3 can be connected to the ligand for protein by a linker to form PROTAC EZH2 Degrader-30 (HY-181359).
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Desamino lenalidomide-Pip-azetidine hydrochloride
0 ImagesCat. No.: HY-W1115217ACAS No.: 2759147-68-5
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(S)-Deoxy-thalidomide-(R)-pyrrolidine-3-carbaldehyde
0 ImagesCat. No.: HY-W1115222CAS No.: 2952806-82-3
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Desamino lenalidomide-Pip-Pip hydrochloride
0 ImagesCat. No.: HY-W1115214ACAS No.: 2500657-00-9
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DGY-02-126-O-C-COOH
0 ImagesCat. No.: HY-W998256CAS No.: 2407829-89-2
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Thalidomide-5-NH-PEG4-NH4 hydrochloride
0 ImagesCat. No.: HY-156166Thalidomide-5-NH-PEG4-NH4 (hydrochloride) is a synthesized compound that incorporates the Thalidomide (HY-14658).
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Thalidomide-piperazine-tert-butyl formate
0 ImagesCat. No.: HY-W998340CAS No.: 2222120-27-4
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Thalidomide-O-amido-C3-NH2 hydrochloride
0 ImagesCat. No.: HY-W998328CAS No.: 2565805-08-3
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2-(2,6-Dioxopiperidin-3-yl)phthalimidine-Piperazine-piperidine hydrochloride
0 ImagesCat. No.: HY-W1115215ACAS No.: 2960183-05-3
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Thalidomide-piperazine-Pip dihydrochloride
0 ImagesCat. No.: HY-W998321CAS No.: 2680528-65-6
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2-(2,6-Dioxopiperidin-3-yl)phthalimidine-Piperazine-piperidine dihydrochloride
0 ImagesCat. No.: HY-W1115215BCAS No.: 2369981-22-4
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(S,R,S)-AHPC-PEG2-C4-Cl (Standard)
0 ImagesCat. No.: HY-103607RCAS No.: 1835705-57-1Synonyms: VH032-PEG2-C4-Cl (Standard); VHL Ligand-Linker Conjugates 7 (Standard); E3 ligase Ligand-Linker Conjugates 10 (Standard)(S,R,S)-AHPC-PEG2-C4-Cl (Standard) is the analytical standard of (S,R,S)-AHPC-PEG2-C4-Cl (HY-103607). This product is intended for research and analytical applications. (S,R,S)-AHPC-PEG2-C4-Cl (VH032-PEG2-C4-Cl) is a conjugate of ligands for E3 and 13-atom-length linker. The connector of linker is Halogen group. (S,R,S)-AHPC-PEG2-C4-Cl incorporates the (S,R,S)-AHPC based VHL ligand and an alkyl/ether-based linker. (S,R,S)-AHPC-PEG2-C4-Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays.
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(S)-Thalidomide-azetidine-O-Pip
0 ImagesCat. No.: HY-W998308CAS No.: 2782051-26-5
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Thalidomide 4'-oxyacetamide-C1-PEG3-C3-amine hydrochloride
0 ImagesCat. No.: HY-139227CAS No.: 2564466-93-7Thalidomide 4'-oxyacetamide-C1-PEG3-C3-amine hydrochloride is a functionalized cereblon ligand for PROTAC research and development with terminal amine ready for conjugation to a target protein ligand.
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Thalidomide-NH-C10-Boc
0 ImagesCat. No.: HY-161961CAS No.: 2428400-25-1Thalidomide-NH-C10-Boc (compound S20) is a conjugate of the E3 ubiquitinase ligand Thalidomide and PROTAC Linker, which can recruit Cereblon ubiquitinase. Thalidomide-NH-C10-Boc can couple the target protein ligand through the PTOTAC Linker to synthesize PROTAC molecules with degradation effects. For example, Thalidomide-NH-C10-Boc can couple with the ligand EP300/CBP ligand 2 (HY-161960) to produce the PROTAC molecule dCE-2 (HY-161958).
