E3 Ligase Ligand-Linker Conjugates
E3 Ligase Ligand-Linker Conjugate, which is one part of Proteolysis Targeting Chimeric Molecules (PROTACs), incorporates a ligand for the E3 ubiquitin ligase and a linker. After linked to the ligand for target protein (such as JQ1 for BRD4 protein, Molibresib for BET protein), those conjugates can be used for constituting PROTACs that targetprotein for ubiquitination and degradation. Currently, several PROTACs have been found to show good biological activity by specifically targeting BET, estrogen receptor (ER), androgen receptor, etc. MedChemExpress (MCE) offers a wide range of high quality E3 Ligase Ligand-Linker Conjugates including von Hippel-Lindau (VHL) ligands, MDM2 ligands, Cereblon (CRBN) ligands and cIAP1 ligands conjugating with different linkers (PEGs, Alkyl-Chain, Alkyl/ether, etc.). It’s convenient and time-saving for designing and synthesizinga wide variety of novel PROTACs (ARV-825, dBET1,MT-802, etc.), which can expand the application of PROTACs in the treatment of cancer, autoimmunity, inflammation and other diseases.
E3 Ligase Ligand-Linker Conjugates Isoform Specific Products
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E3 Ligase Ligand-Linker Conjugates Related Products (1117)
Related Products (1117)
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Antibodies (1)
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E3 Ligase Ligand-Linker Conjugates Isoform Comparison
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Desamino lenalidomide-alkyne-C-piperazin
0 ImagesCat. No.: HY-W1114861CAS No.: 2801714-66-7
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(S,R,S)-AHPC-CO-C-PEG5-amine hydrochloride
0 ImagesCat. No.: HY-W998297CAS No.: 2377275-23-3
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Pomalidomide-C3-alkyne
0 ImagesCat. No.: HY-W998285CAS No.: 2154356-75-7
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(S)-Thalidomide-piperazin besylate
0 ImagesCat. No.: HY-W998237CAS No.: 2937046-84-7
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Thalidomide-piperidin-C-piperidin hydrochloride
0 ImagesCat. No.: HY-W998301CAS No.: 3037676-85-7
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Thalidomide-(1-(3-azetidinylmethyl)piperazine)
0 ImagesCat. No.: HY-W998304CAS No.: 2229717-78-4
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Desamino lenalidomide-acetylene-C-piperazine hydrochloride
0 ImagesCat. No.: HY-W1114863CAS No.: 3035032-11-9
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Thalidomide-piperidin-C-piperidin
0 ImagesCat. No.: HY-W998300CAS No.: 2714477-27-5
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Lenalidomide-acetylene-C3-MsO
0 ImagesCat. No.: HY-159145CAS No.: 2138441-31-1
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Dihydrouracil-Ph-piperazine-Boc
0 ImagesCat. No.: HY-W592697CAS No.: 2446914-63-0
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Thalidomide-5-piperazine-azetidine
0 ImagesCat. No.: HY-W998307CAS No.: 2680530-60-1
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3-(1-Oxo-5-(3,9-diazaspiro[5.5]undecan-3-yl)isoindolin-2-yl)piperidine-2,6-dione
![3-(1-Oxo-5-(3,9-diazaspiro[5.5]undecan-3-yl)isoindolin-2-yl)piperidine-2,6-dione](https://file.medchemexpress.com/product_pic/hy-w1115214.gif "Click to View 3-(1-Oxo-5-(3,9-diazaspiro[5.5]undecan-3-yl)isoindolin-2-yl)piperidine-2,6-dione Product Detail")
0 ImagesCat. No.: HY-W1115214CAS No.: 2500656-99-3
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(S,R,S)-AHPC-PEG6-C4-Cl (Standard)
0 ImagesCat. No.: HY-103606RCAS No.: 1835705-59-3Synonyms: VH032-PEG6-C4-Cl (Standard); VHL Ligand-Linker Conjugates 10 (Standard); E3 ligase Ligand-Linker Conjugates 9 (Standard)(S,R,S)-AHPC-PEG6-C4-Cl (Standard) is the analytical standard of (S,R,S)-AHPC-PEG6-C4-Cl (HY-103606). This product is intended for research and analytical applications. (S,R,S)-AHPC-PEG6-C4-Cl is a conjugate of ligands for E3 and 25-atom-length linker. The connector of linker is Halogen group. (S,R,S)-AHPC-PEG6-C4-Cl incorporates the (S,R,S)-AHPC based VHL ligand and 6-unit PEG linker. (S,R,S)-AHPC-PEG6-C4-Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays.
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(S)-Phthalimidinoglutarimide-6-piperazine
0 ImagesCat. No.: HY-W797383ACAS No.: 2986073-45-2(S)-Phthalimidinoglutarimide-6-piperazine is the (S)-configuration of Phthalimidinoglutarimide-6-piperazine (HY-W797383). (S)-Phthalimidinoglutarimide-6-piperazine is an E3 ligase ligand-linker conjugate. (S)-Phthalimidinoglutarimide-6-piperazine can be used for synthesis of PROTAC SMARCA2 degrader-35 (HY-176871).
