E3 Ligase Ligand-Linker Conjugates
E3 Ligase Ligand-Linker Conjugate, which is one part of Proteolysis Targeting Chimeric Molecules (PROTACs), incorporates a ligand for the E3 ubiquitin ligase and a linker. After linked to the ligand for target protein (such as JQ1 for BRD4 protein, Molibresib for BET protein), those conjugates can be used for constituting PROTACs that targetprotein for ubiquitination and degradation. Currently, several PROTACs have been found to show good biological activity by specifically targeting BET, estrogen receptor (ER), androgen receptor, etc. MedChemExpress (MCE) offers a wide range of high quality E3 Ligase Ligand-Linker Conjugates including von Hippel-Lindau (VHL) ligands, MDM2 ligands, Cereblon (CRBN) ligands and cIAP1 ligands conjugating with different linkers (PEGs, Alkyl-Chain, Alkyl/ether, etc.). It’s convenient and time-saving for designing and synthesizinga wide variety of novel PROTACs (ARV-825, dBET1,MT-802, etc.), which can expand the application of PROTACs in the treatment of cancer, autoimmunity, inflammation and other diseases.
E3 Ligase Ligand-Linker Conjugates Isoform Specific Products
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E3 Ligase Ligand-Linker Conjugates Related Products (1117)
Related Products (1117)
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Antibodies (1)
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E3 Ligase Ligand-Linker Conjugates Isoform Comparison
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Pomalidomide-C2-amide-C5-azide
0 ImagesCat. No.: HY-160235CAS No.: 2732859-29-7
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Pomalidomide-PEG3-OH
0 ImagesCat. No.: HY-W924948CAS No.: 2140807-36-7Pomalidomide-PEG3-OH (compound 53b) is an E3 Ligase Ligand-Linker Conjugates consisting of a pomalidomide (HY-10984)-based cereblon ligand and a 3-unit PEG linker.
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(S)-Deoxy-thalidomide-Pip-3-hydroxypropanoic acid hydrochloride
0 ImagesCat. No.: HY-W1114864ACAS No.: 3032320-79-6
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Desamino lenalidomide-Pip-CO-piperazine hydrochloride
0 ImagesCat. No.: HY-W1114859CAS No.: 2933214-25-4
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Desamino lenalidomide-piperazine hydrochloride
0 ImagesCat. No.: HY-W998272CAS No.: 2229724-14-3
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Pomalidomide 4'-alkylC2-azide
0 ImagesCat. No.: HY-139343CAS No.: 2296708-61-5Pomalidomide 4'-alkylC2-azide (compound 2a) is an E3 ligase ligand-linker conjugate containing a Pomalidomide (HY-10984) based cereblon (CRBN) ligand and a linker. Pomalidomide 4'-alkylC2-azide can be used in the synthesis of PROTAC.
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Thalidomide-4-O-C8-Br
0 ImagesCat. No.: HY-W945789CAS No.: 2653338-55-5
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Thalidomide-O-PEG5-alkyne
0 ImagesCat. No.: HY-W190931CAS No.: 2411681-90-6
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6-(2,6-Dioxopiperidin-3-yl)-2-(piperazin-1-yl)-5H-pyrrolo[3,4-d]pyrimidine-5,7(6H)-dione hydrochloride
![6-(2,6-Dioxopiperidin-3-yl)-2-(piperazin-1-yl)-5H-pyrrolo[3,4-d]pyrimidine-5,7(6H)-dione hydrochloride](https://file.medchemexpress.com/product_pic/hy-w998269.gif "Click to View 6-(2,6-Dioxopiperidin-3-yl)-2-(piperazin-1-yl)-5H-pyrrolo[3,4-d]pyrimidine-5,7(6H)-dione hydrochloride Product Detail")
0 ImagesCat. No.: HY-W998269CAS No.: 2229738-21-8
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3-(4-(5-Hydroxypent-1-yn-1-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione
0 ImagesCat. No.: HY-W998281CAS No.: 2138441-30-03-(4-(5-Hydroxypent-1-yn-1-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione (Compound 15c) is an important intermediate in the synthesis of RET Degrader.
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(S,R,S)-AHPC-PEG5-Azide
0 ImagesCat. No.: HY-W1130361CAS No.: 3036242-05-1(S,R,S)-AHPC-PEG5-Azide is a VHL ligand based on (S,R,S)-AHPC that recruits von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC-PEG5-Azide can be linked to a target protein ligand via a linker to form a PROTACs.
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(S,R,S)-AHPC-PEG3-NH2 hydrochloride (Standard)
0 ImagesCat. No.: HY-103602RCAS No.: 2097971-11-2Synonyms: VH032-PEG3-NH2 hydrochloride (Standard); VHL Ligand-Linker Conjugates 1 hydrochloride (Standard); E3 ligase Ligand-Linker Conjugates 5 (Standard)(S,R,S)-AHPC-PEG3-NH2 hydrochloride (Standard) is the analytical standard of (S,R,S)-AHPC-PEG3-NH2 hydrochloride (HY-103602). This product is intended for research and analytical applications. (S,R,S)-AHPC-PEG3-NH2 (VH032-PEG3-NH2) hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 3-unit PEG linker used in PROTAC technology.
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3-Azathalidomide-piperazine
0 ImagesCat. No.: HY-W998268CAS No.: 2589702-05-4
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Thalidomide-6-F-5-Pip-COOH
0 ImagesCat. No.: HY-W998242CAS No.: 2884557-96-2
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Thalidomide-Pip-CH2-piperazine
0 ImagesCat. No.: HY-W998299CAS No.: 2229725-34-0
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(S,R,S,R)-AHPC-Me-CO-C7-N3
0 ImagesCat. No.: HY-181356CAS No.: 2977227-44-2(S,R,S,R)-AHPC-Me-CO-C7-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S,R)-AHPC-Me based VHL ligand and a linker used in PROTAC technology. (S,R,S,R)-AHPC-Me-CO-C7-N3 can be connected to the ligand for protein by a linker to form PROTAC EZH2 Degrader-28 (HY-181355).
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Thalidomide-O-amido-C3-COOH TFA
0 ImagesCat. No.: HY-W998312CAS No.: 3037693-14-1
