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Cat. No.: HY-168282

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DD205-291

DD205-291 is an orally active PROTAC HPK1 degrader, with a DC₅₀ value of 5.3 nM. DD205-291 inhibits SLP-76 phosphorylation and induces IL-2 and IFN-γ expression (Pink: HPK1 protein ligand HY-168283; E3+linker: HY-168284; Blue: E3: HY-W115490; Black: linker: HY-W210252).
(Pink: HPK1 ligand (HY-168283); Blue: Cereblon ligand (HY-W115490); Black: linker).

For research use only. We do not sell to patients.

CAS No.: 3047066-15-6
Formula: C₃₈H₃₈ClF₃N₁₀O₃
Molecular Weight:775.22

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

DD205-291 Chemical Structure

CAS No.: 3047066-15-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

DD205-291 is an orally active PROTAC HPK1 degrader, with a DC₅₀ value of 5.3 nM. DD205-291 inhibits SLP-76 phosphorylation and induces IL-2 and IFN-γ expression (Pink: HPK1 protein ligand HY-168283; E3+linker: HY-168284; Blue: E3: HY-W115490; Black: linker: HY-W210252)^[1]. (Pink: HPK1 ligand (HY-168283); Blue: Cereblon ligand (HY-W115490); Black: linker).

All PROTACs Isoforms :

All MAP4K Isoforms :

Chemical Information

CAS No. 3047066-15-6
Molecular Weight 775.22
Formula C₃₈H₃₈ClF₃N₁₀O₃
SMILES

O=C(N1)N(C2=C(C=CC(C(N3CCC(CC3)CC4CCN(CC4)C5=CC=C(C=N5)C6=NC7=C(NC=C7C8=CN(N=C8)CC(F)(F)F)N=C6)=O)=C2)Cl)CCC1=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhang Z, et al. Discovery of Novel PROTAC-Based HPK1 Degraders with High Potency and Selectivity for Cancer Immunotherapy. J Med Chem. 2024 Nov 14;67(21):18682-18698. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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DD205-291

All PROTACs Isoforms

All MAP4K Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

DD205-291 Related Classifications

HY-168282 Related Classifications