E3 Ligase Ligand-Linker Conjugates
E3 Ligase Ligand-Linker Conjugate, which is one part of Proteolysis Targeting Chimeric Molecules (PROTACs), incorporates a ligand for the E3 ubiquitin ligase and a linker. After linked to the ligand for target protein (such as JQ1 for BRD4 protein, Molibresib for BET protein), those conjugates can be used for constituting PROTACs that targetprotein for ubiquitination and degradation. Currently, several PROTACs have been found to show good biological activity by specifically targeting BET, estrogen receptor (ER), androgen receptor, etc. MedChemExpress (MCE) offers a wide range of high quality E3 Ligase Ligand-Linker Conjugates including von Hippel-Lindau (VHL) ligands, MDM2 ligands, Cereblon (CRBN) ligands and cIAP1 ligands conjugating with different linkers (PEGs, Alkyl-Chain, Alkyl/ether, etc.). It’s convenient and time-saving for designing and synthesizinga wide variety of novel PROTACs (ARV-825, dBET1,MT-802, etc.), which can expand the application of PROTACs in the treatment of cancer, autoimmunity, inflammation and other diseases.
E3 Ligase Ligand-Linker Conjugates Isoform Specific Products
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E3 Ligase Ligand-Linker Conjugates Related Products (1116)
Related Products (1116)
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Antibodies (1)
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E3 Ligase Ligand-Linker Conjugates Isoform Comparison
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Lenalidomide-COCH-PEG2-azido
0 ImagesCat. No.: HY-163647CAS No.: 2380273-88-9Lenalidomide-COCH-PEG2-azido is a synthesized E3 ligase ligand-linker conjugate that incorporates the Lenalidomide (HY-A0003) based cereblon ligand and a linker. Lenalidomide-COCH-PEG2-azido can be used in the synthesis of PROTAC AKR1C3 degrader-1 (HY-163609).
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Desamino lenalidomide-pent-4-yn-1-ol
0 ImagesCat. No.: HY-W998279CAS No.: 2229714-98-9
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Thalidomide-((3R)-3-pyrrolidinemethanol)
0 ImagesCat. No.: HY-W998330CAS No.: 2416132-50-6
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(S,R,S)-AHPC-PEG4-NH2 (Standard)
0 ImagesCat. No.: HY-103604ARCAS No.: 2010159-57-4Synonyms: VH032-PEG4-NH2 (Standard); VHL Ligand-Linker Conjugates 4 (Standard); E3 ligase Ligand-Linker Conjugates 7 Free Base (Standard)(S,R,S)-AHPC-PEG4-NH2 (Standard) is the analytical standard of (S,R,S)-AHPC-PEG4-NH2 (HY-103604A). This product is intended for research and analytical applications. (S,R,S)-AHPC-PEG4-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology.
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tert-Butyl (S)-5-amino-4-(4-hydroxy-1-oxoisoindolin-2-yl)-5-oxopentanoate
0 ImagesCat. No.: HY-W613598CAS No.: 1560678-51-4
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Lenalidomide 5'-piperazine-C1-piperidine
0 ImagesCat. No.: HY-W1003884CAS No.: 2520105-46-6
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(S,R,S)-AHPC-Me-CO-C3-COOH
0 ImagesCat. No.: HY-W998315CAS No.: 2349429-72-5
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Thalidomide-5-piperazine
0 ImagesCat. No.: HY-W834174CAS No.: 2154342-61-5
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Thalidomide-O-amido-C8-NH2
0 ImagesCat. No.: HY-107439CAS No.: 1950635-15-0Synonyms: Cereblon Ligand-Linker Conjugates 2; E3 Ligase Ligand-Linker Conjugates 20Thalidomide-O-amido-C8-NH2 (Cereblon Ligand-Linker Conjugates 2), a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs.
