1. PROTAC
  2. Ligand for E3 Ligase
  3. Pomalidomide-5-OH

Pomalidomide-5-OH (Synonyms: 5-Hydroxy pomalidomide; CC-17368)

Cat. No.: HY-123324
Handling Instructions

Pomalidomide-5-OH (5-hydroxy pomalidomide) is the Pomalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Pomalidomide-5-OH can be connected to the ligand for protein by a linker to form PROTAC.

For research use only. We do not sell to patients.

Pomalidomide-5-OH Chemical Structure

Pomalidomide-5-OH Chemical Structure

CAS No. : 1547162-41-3

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Description

Pomalidomide-5-OH (5-hydroxy pomalidomide) is the Pomalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Pomalidomide-5-OH can be connected to the ligand for protein by a linker to form PROTAC[1].

IC50 & Target[1]

Cereblon

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

289.24

Formula

C₁₃H₁₁N₃O₅

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Product Name:
Pomalidomide-5-OH
Cat. No.:
HY-123324
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