2. Signaling Pathways
  3. Metabolic Enzyme/Protease
    Neuronal Signaling
  4. FAAH

FAAH

Fatty acid amide hydrolase

FAAH

Related Products

PDF 0.4 MB

FAAH (Fatty acid amide hydrolase) is a membrane-bound protein belonging to serine hydrolase family of enzymes.FAAH is responsible for the hydrolysis of a number of important endogenous fatty acid amides, including the endogenous cannabimimetic agent anandamide (AEA), the sleep-inducing compound oleamide, and the putative anti-inflammatory agent palmitoylethanolamide (PEA). FAAH plays a significant role in termination of signalling of a class of bioactive lipids called fatty acid amides (FAAs) both in the central nervous system (CNS) and peripheral tissues.

FAAH belongs to the amidase signature (AS) superfamily and is widely distributed in multicellular eukaryotes. FAAH has a key role in the control of the cannabinoid signaling, through the hydrolysis of the endocannabinoids anandamide and in some tissues 2-arachidonoylglycerol.

Cat. No. 상품명 효과 Purity Chemical Structure
  • HY-143263
    FAAH/MAGL-IN-1
    		Inhibitor
    FAAH/MAGL-IN-1 (compound SIH 3) is a potent FAAH and MAGL inhibitor with IC50s of 31 nM and 29 nM, respectively. FAAH/MAGL-IN-1 has the potential for the research of neuropathic pain.
    FAAH/MAGL-IN-1
  • HY-103463
    SA57
    		Inhibitor ≥99.0%
    SA57 is a potent, selective FAAH inhibitor with IC50s of 3.2 nM and 1.9 nM for mouse and human FAAH. SA57 also inhibits the 2-arachidonoylglycerol hydrolases MAGL (IC50s of 410 nM and 1.4 μM for mouse and human MAGL) and mouse α/β-hydrolase domain-containing protein 6 (mABHD6; IC50 of 850 nM), but not other brain serine hydrolases.
    SA57
  • HY-B1227S
    Carprofen-d3
    		Inhibitor
    Carprofen-d3 is the deuterium labeled Carprofen. Carprofen is a nonsteroid anti-inflammatory agent, acts as a multi-target FAAH/COX inhibitor, with IC50s of 3.9 μM, 22.3 μM and 78.6 μM for COX-2, COX-1 and FAAH, respectively.
    Carprofen-d<sub>3</sub>
  • HY-143264
    FAAH/MAGL-IN-2
    		Inhibitor
    FAAH/MAGL-IN-2 is a potent, reversible, orally active, and cross the blood-brain barrier FAAH and MAGL inhibitor with IC50s of 11 nM and 36 nM (Kis of 28 nM and 60 nM), respectively . FAAH/MAGL-IN-2 has the potential to research neuropathic pain without causing locomotion impairment.
    FAAH/MAGL-IN-2
  • HY-152253
    CB2R/FAAH modulator-2
    		Inhibitor
    CB2R/FAAH modulator-2 (compound 26) is a dual targeting modulator that acts as a CB2R agonist and FAAH inhibitor. The Ki values for CB2R/FAAH modulator-2 are 10.8 and 152.9 nM for CB2R and CB1R, respectively, and the IC50 value for FAAH is 6.2 μM. CB2R/FAAH modulator-2 can be used in studies related to cancer, deleterious inflammatory cascades occurring in neurodegenerative diseases, and COVID-19 infection.
    CB2R/FAAH modulator-2
  • HY-151919
    FAAH-IN-7
    		Inhibitor
    FAAH-IN-7 is a reversible and potent FAAH inhibitor with an IC50 value of 8.29 nM. FAAH-IN-7 suppresses oxidative stress in 1321N1 astrocytes and exhibits notable neuroprotective effect in ex vivo neuroinflammation model.
    FAAH-IN-7
  • HY-120369
    URB532
    		Inhibitor
    URB532 is an inhibitor for fatty acid amide hydrolase (FAAH) with an IC50 of 396 nM. URB532 increases levels of arachidonic acid acetamide (AEA), palmitoylethanolamide (PEA), and oleamide (OEA) in the rat brain, and exhibits anxiolytic and analgesic effects.
    URB532
  • HY-N2365R
    Macamide B (Standard)
    		Inhibitor
    Macamide B (Standard) is the analytical standard of Macamide B. This product is intended for research and analytical applications. Macamide B (N-Benzylhexadecanamide; Macamide 1) is a macamide isolated from Lepidium meyenii, acts as an inhibitor of fatty acid amide hydrolase (FAAH).
    Macamide B (Standard)
  • HY-146341
    FAAH-IN-5
    		Inhibitor
    FAAH-IN-5 (Compound 7) is a relative selective, irreversible fatty acid amide hydrolase (FAAH) inhibitor with an IC50 of 10.5 nM. FAAH-IN-5 shows low PAMPA (Parallel Artificial Membrane Permeability Assay) permeability.
    FAAH-IN-5
  • HY-152251
    CB2R/FAAH modulator-1
    		Inhibitor 99.14%
    CB2R/FAAH modulator-1 is a cannabinoid type 2 receptor (CB2R) full agonist with Kis of 14.8 nM and 241.3 nM for CB2R and CB1R, respectively. CB2R/FAAH modulator-1 is a fatty acid amide hydrolase (FAAH) inhibitor with an IC50 of 4 μM. CB2R/FAAH modulator-1 decreases pro-inflammatory and increases anti-inflammatory cytokines production.
    CB2R/FAAH modulator-1
  • HY-139143
    WWL154
    		Inhibitor 98.96%
    WWL154, an analog of JZL184 that maintains the SH-reactive p-nitrophenyl carbamate group, is a FAAH-4 inhibitor.
    WWL154
  • HY-W728451
    URB694
    		Inhibitor
    URB694 is a carbamate FAAH inhibitor that irreversibly carbamoylate the nucleophile catalytic serine in FAAH active site. URB694 exhibits antidepressant-like activity and cardioprotective effects. URB694 can be used to prepare 11C-Carbonyl-URB694 for in vivo positron emission tomography (PET) imaging studies of the brain FAAH.
    URB694
  • HY-147910
    Carpro-AM1
    		Inhibitor
    Carpro-AM1 is a dual-acting FAAH/substrate-selective COX inhibitor with an IC50 value of 94 nM for FAAH.
    Carpro-AM1
  • HY-122159
    MDPD
    		Activator
    MDPD is an Arabidopsis FAAH (AtFAAH) activator that can enhance the enzymatic activity of AtFAAH.
    MDPD
  • HY-138693
    ST4070
    		Inhibitor
    ST4070 is a potent, orally active, and selective reversible fatty acid amide hydrolase (FAAH) inhibitor. ST4070 increases endocannabinoid (eCB) brain levels and counteracts neuropathic pain in animal models. ST4070 enhances the endogenous eCB tone in specific brain regions engaged in emotional control, and induces remarkable anxiolytic-like behaviours in rodents. ST4070 can be used for neuropathic pain and anxiety disorders research.
    ST4070
  • HY-12909
    MK-4409
    		Inhibitor
    MK-4409 is a potent oxazole FAAH inhibitor and can be used for the research of inflammatory and neuropathic pain.
    MK-4409
  • HY-168563
    BuChE-IN-15
    		Inhibitor
    BuChE-IN-15 (compound D12) is a selective BuChE/FAAH dual inhibitor with and show IC50 values of 81 and 400 nM for hBuChE and hFFAH, respectively. BuChE-IN-15 possesses good BBB penetration, and shows neuroprotection.BuChE-IN-15 can be used for study of Alzheimer.
    BuChE-IN-15
  • HY-116798
    URB524
    		Inhibitor
    URB524 is an irreversible FAAH inhibitor of O-aryl amino acid esters. URB524 inhibits FAAH by aminoformylation of Ser241. URB524 exhibits analgesic, antidepressant, and anti anxiety activity.
    URB524
  • HY-10862R
    FAAH inhibitor 1 (Standard)
    		Inhibitor
    FAAH inhibitor 1 (Standard) is the analytical standard of FAAH inhibitor 1 (HY-10862). This product is intended for research and analytical applications. FAAH inhibitor 1 (compound 3) is a selective reversible FAAH inhibitor. FAAH inhibitor 1 has no off-target activity with respect to other serine hydrolases. FAAH inhibitor 1 is exclusively specific against FAAH in rat brain with an IC50 value of 18 nM and had no missing protein bands in all the other tissues. FAAH inhibitor 1 can be used for neurological disorders research.
    FAAH inhibitor 1 (Standard)
  • HY-164506
    NRMA-8
    		Modulator
    NRMA-8 is a brain-penetrant small molecule nuclear receptor modulator. NRMA-8 is promising for research of central nervous system disorders, including Alzheimer's disease, Parkinson's disease, demylenation disorders and glioblastomas.
    NRMA-8
Cat. No. 상품명 / Synonyms Application Reactivity