1. Signaling Pathways
  2. NF-κB
  3. IKK
  4. IKKε Isoform
  5. IKKε Inhibitor

IKKε Inhibitor

IKKε Inhibitors (10):

Cat. No. Product Name Effect Purity
  • HY-10514
    BX795
    Inhibitor 99.17%
    BX795 is a potent and selective inhibitor of PDK1, with an IC50 of 6 nM.
  • HY-13018
    MRT67307
    Inhibitor 99.34%
    MRT67307 is a dual inhibitor of the IKKε and TBK-1 with IC50s of 160 and 19 nM, respectively.
  • HY-B0713
    Amlexanox
    Inhibitor 99.88%
    Amlexanox (AA673; Amoxanox; CHX3673) is a specific inhibitor of IKKε and TBK1, and inhibits the IKKε and TBK1 activity determined by MBP phosphorylation with an IC50 of approximately 1-2 μM.
  • HY-133117
    BAY-985
    Inhibitor 99.88%
    BAY-985 is a highly potent, orally active and selective ATP-competitive dual inhibitor of TBK1 and IKKε with IC50s of 2/30 and 2 nM for TBK1 (low/high ATP) and IKKε, respectively.
  • HY-12453
    TBK1/IKKε-IN-2
    Inhibitor 98.09%
    TBK1/IKKε-IN-2 is a dual TBK1 and IKKε inhibitor.
  • HY-14682
    GSK319347A
    Inhibitor 99.40%
    GSK319347A is a dual inhibitor of TBK1 and IKKε with IC50s of 93 nM and 469 nM, respectively.
  • HY-124652
    TBK1/IKKε-IN-4
    Inhibitor 99.83%
    TBK1/IKKε-IN-4 is a 6-aminopyrazolopyrimidine derivative and a potent, selective TBK1 and IKKε inhibitor with IC50 values of 13 nM and 59 nM, respectively.
  • HY-135366
    HPN-01
    Inhibitor 98.40%
    HPN-01 is a potent and selective IKK inhibitor, with pIC50 values of 6.4, 7.0 and <4.8 for IKK-α, IKK-β and IKK-ε, respectively.
  • HY-13018A
    MRT67307 hydrochloride
    Inhibitor
    MRT67307 hydrochloride is a dual inhibitor of the IKKε and TBK-1 with IC50s of 160 and 19 nM, respectively.
  • HY-U00457
    TBK1/IKKε-IN-1
    Inhibitor
    TBK1/IKKε-IN-1 is a dual TBK1 and IKKε inhibitor extracted from patent US20160376283 A1, Compound 274 in Example 60, has IC50s of <100 nM.