928655-63-4
928655-63-4
Chemical Structure
HPN-01
- CAS No.: 928655-63-4
- Formula:C19H16ClN3O3S
- Molecular Weight:401.87
IUPAC Name: 4'-amino-4-chloro-4''-sulfamoyl-[1,1':3',1''-terphenyl]-5'-carboxamide
InChIKey: XJLFMRGTLRIXDT-UHFFFAOYSA-N
SMILES: O=C(C1=C(N)C(C2=CC=C(S(=O)(N)=O)C=C2)=CC(C3=CC=C(Cl)C=C3)=C1)N
Biological Activity: HPN-01 is a potent and selective IKK inhibitor, with pIC50 values of 6.4, 7.0 and <4.8 for IKK-α, IKK-β and IKK-ε, respectively. HPN-01 displays greater 50-fold selectivity over a panel of more than 50 other kinases, including ALK5, CDK-2, EGFR, ErbB2, GSK3β, PLK1, Src, and VEGFR-2[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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HPN-01 | 98.61% | HPN-01 is a potent and selective IKK inhibitor, with pIC50 values of 6.4, 7.0 and <4.8 for IKK-α, IKK-β and IKK-ε, respectively. HPN-01 displays greater 50-fold selectivity over a panel of more than 50 other kinases, including ALK5, CDK-2, EGFR, ErbB2, GSK3β, PLK1, Src, and VEGFR-2. | ||||||||||||||||||||
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References
Keywords
