Kinesin Inhibitor

Ispinesib (Standard) is the analytical standard of Ispinesib. This product is intended for research and analytical applications. Ispinesib is a specific inhibitor of kinesin spindle protein (KSP), with a Ki app of 1.7 nM.

UA62784 is a microtubule polymerization inhibitor that interacts with tubulin dimers. UA62784 is a novel specific inhibitor of centromere protein E (CENP-E) kinesin. UA62784 can be used for the study of pancreatic cancer.

Paprotrain (Standard) is the analytical standard of Paprotrain (HY-101298). This product is intended for research and analytical applications. Paprotrain is a cell-permeable inhibitor of the kinesin MKLP-2, inhibits the ATPase activity of MKLP-2 with an IC50 of 1.35 μM and a Ki of 3.36 μM and shows a moderate inhibition activity on DYRK1A with an IC50 of 5.5 μM.

KSP-IN-2 (compound 12) is a kinesin spindle protein (KSP) inhibitor with an IC₅₀ of 450 nM.

NSC-80141 is a Kinesin-5 inhibitor. NSC-80141 exerts selective inhibitory activity against human kinesin-5 (HsEg5) (IC₅₀: 9.4 μM), while shows weak inhibitory activity against Plasmodium kinesin-5 (PvEg5) (IC₅₀: 27.3 μM). NSC-80141 serves as a tool compound for distinguishing human and Plasmodium homologous proteins.