LPL Receptor
Lysophospholipid Receptor
LPL Receptor (Lysophospholipid Receptor) group are members of the G protein-coupled receptor family of integral membrane proteins that are important for lipid signaling. In humans, there are eight LPL receptors, each encoded by a separate gene. These LPL receptor genes are also sometimes referred to as "Edg". LPL receptor ligands bind to and activate their cognate receptors located in the cell membrane. Depending on which ligand, receptor, and cell type is involved, the activated receptor can have a range of effects on the cell. These include primary effects of inhibition of adenylyl cyclase and release of calcium from the endoplasmic reticulum, as well as secondary effects of preventingapoptosis and increasing cell proliferation. Type: LPAR1, LPAR2, LPAR3, LPAR4, LPAR5, LPAR6, S1PR1, S1PR2, S1PR3, S1PR4, S1PR5.
LPL Receptor Isoform Specific Products
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LPL Receptor Inhibitors
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LPL Receptor Agonists
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LPL Receptor Antagonists
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LPL Receptor Activators
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LPL Receptor Modulators
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LPL Receptor Control
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LPL Receptor Ligand
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LPL Receptor Related Products (278)
Related Products (278)
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Antibodies (7)
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LPL Receptor Isoform Comparison
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RP-1859
0 ImagesCat. No.: HY-137973CAS No.: 1307869-95-9RP-1859 is a sphingosine 1-phosphate receptor (S1P) modulator. RP-1859 exerts anti-inflammatory and immunomodulatory activities. RP-1859 can be used for the research of iatrogenic autoimmune colitis.
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Zectivimod
0 ImagesZectivimod is a sphingosine-1-phosphate receptor agonist. Zectivimod can be used for the research of autoimmune diseases，chronic inflammatory diseases and immunoregulation disorders.
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S1PR1/S1PR5 agonist-1
0 ImagesCat. No.: HY-181875S1PR1/S1PR5 agonist-1 (Compound 19) is an orally active S1PR1 and S1PR5 agonist with EC50 values of 40.0 and 22.9 nM, respectively. S1PR1/S1PR5 agonist-1 binds to key residues of S1PR1 to mediate agonistic activity. S1PR1/S1PR5 agonist-1 alleviates colitis pathological changes in DSS-induced mouse models and exerts minimal effects on mouse heart rate. S1PR1/S1PR5 agonist-1 can be used for the research of inflammatory bowel disease.
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Sumonerimod hemicalcium
0 ImagesCat. No.: HY-156565ACAS No.: 2941310-03-6Synonyms: S1P1 agonist 6 hemicalciumS1P1 agonist 6 hemicalcium (Compound I) is a S1P1 agonist that reduces autoimmune ability by blocking the transportation of lymphocytes. S1P1 agonist 6 hemicalcium can be used as an immunosuppressive agent in the study of various autoimmune diseases research.
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Myristoyl pentapeptide-17
0 ImagesCat. No.: HY-P0103CAS No.: 959610-30-1Myristoyl pentapeptide-17 can stimulate eyelash growth by stimulating keratin production. Myristoyl pentapeptide-17 promotes the delivery of key ingredients in the serum, such as the growth factors and lysophosphatidic acid.
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BMS-960
0 ImagesCat. No.: HY-120611ACAS No.: 1265323-40-7BMS-960 is a potent and selective S1P1 receptor agonist containing isoxazole, which can be used in the research of immune diseases and vascular diseases.
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CYM50358 hydrochloride
0 ImagesCat. No.: HY-110314CAS No.: 1781750-72-8CYM50358 hydrochloride (compound 4v) is a potent, selective sphingosine-1-phosphate 4 (S1P4) receptor antagonist. CYM50358 hydrochloride can be used in the study of influenza infection.
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TYY-31
0 ImagesCat. No.: HY-183578TYY-31 is an orally active, selective S1PR1 agonist with an EC50 of 1.13 pM. TYY-31 promotes the phosphorylation of ERK1/2. TYY-31 exerts anti-inflammatory and immunosuppressive effects, ameliorates DSS-induced colitis in mice, and reduces peripheral blood lymphocyte counts in mice in a dose-dependent manner. TYY-31 can be used for the research of ulcerative colitis.
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S1PR1 agonist 1
0 ImagesCat. No.: HY-143864CAS No.: 2700209-37-4S1PR1 agonist 1 is a potent agonist of S1PR1. Sphingosine-1-phosphate (S1P) is a cell membrane-derived lysophospholipid signalling molecule that exerts its physiological functions mainly by stimulating some members of the G protein-coupled receptor family. S1PR1 agonist 1 has the potential for the research of autoimmune diseases (extracted from patent WO2021175223A1, compound 22).
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CS-0777
0 ImagesCat. No.: HY-14976CAS No.: 827344-05-8CS-0777 is a selective, orally active sphingosine 1-phosphate receptor-1 modulator. CS-0777 can be used in the research of autoimmune diseases.
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LPA1 receptor antagonist-7
0 ImagesCat. No.: HY-182787CAS No.: 3057457-78-7LPA1 receptor antagonist-7 is a LPA1 antagonist. LPA1 receptor antagonist-7 blocks downstream signaling pathways mediated by LPA1. LPA1 receptor antagonist-7 inhibits LPA-induced migration and invasion of cancer cells. LPA1 receptor antagonist-7 can be used for the research of triple-negative breast cancer.
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S1PR1 agonist 2
0 ImagesCat. No.: HY-143865CAS No.: 2695535-01-2S1PR1 agonist 2 is a potent agonist of S1PR1. Sphingosine-1-phosphate (S1P) is a cell membrane-derived lysophospholipid signalling molecule that exerts its physiological functions mainly by stimulating some members of the G protein-coupled receptor family. S1PR1 agonist 2 has the potential for the research of autoimmune diseases (extracted from patent WO2021175225A1, compound 1).
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S1P5 receptor antagonist 1
0 ImagesCat. No.: HY-164584CAS No.: 1621065-22-2S1P5 receptor antagonist 1 is a selective, blood-brain barrier-permeable S1P5 receptor antagonist with an EC50 of 0.1 nM and a Ki of 4.4 nM. S1P5 receptor antagonist 1 inhibits the migration of natural killer cells towards sphingosine 1-phosphate in vitro, with no effect on T cell migration. S1P5 receptor antagonist 1 can be used in the research of central nervous system diseases.
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Fingolimod phosphate-d4
0 ImagesCat. No.: HY-15381SCAS No.: 1794828-93-5Synonyms: FTY720 phosphate-d4Fingolimod phosphate-d4 is deuterium labeled FTY720 Phosphate.
