1055027-48-9
1055027-48-9
Chemical Structure
LX2932
- CAS. Nr.: 1055027-48-9
- Formula:C10H13N3O5
- Molecular Weight:255.23
IUPAC Name: (1R,2S,3R)-1-(2-(isoxazol-3-yl)-1H-imidazol-5-yl)butane-1,2,3,4-tetraol
InChIKey: WGDPRIZUIYIENM-IWSPIJDZSA-N
SMILES: [C@@H]([C@@H]([C@@H](CO)O)O)(O)C=1NC(=NC1)C=2C=CON2
Biological Activity: LX2932 is an orally active LX2931 (HY-14370) analogue and S1P/S1PR signaling axis modulator. LX2932 yields a dose-dependent decrease in circulating lymphocyte numbers. LX2932 improves collagen-induced arthritis[1][2].
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LX2932 | LX2932 is an orally active LX2931 (HY-14370) analogue and S1P/S1PR signaling axis modulator. LX2932 yields a dose-dependent decrease in circulating lymphocyte numbers. LX2932 improves collagen-induced arthritis. | |||||||||||||||||||||
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References
- [1]. Bagdanoff JT, et al. Inhibition of sphingosine 1-phosphate lyase for the treatment of rheumatoid arthritis: discovery of (E)-1-(4-((1R,2S,3R)-1,2,3,4-tetrahydroxybutyl)-1H-imidazol-2-yl)ethanone oxime (LX2931) and (1R,2S,3R)-1-(2-(isoxazol-3-yl)-1H-imidazol-4-yl)butane-1,2,3,4-tetraol (LX2932). J Med Chem. 2010 Dec 23;53(24):8650-62. [Content Brief]
- [2]. Gao Y, et al. Rheumatoid arthritis: pathogenesis and therapeutic advances. MedComm (2020). 2024 Mar 10;5(3):e509. [Content Brief]
