S1PR4 Modulator
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Vonifimod
0 ImagesCat. No.: HY-148805CAS No.: 2118903-18-5Synonyms: SLB736 free acidVonifimod (SLB736 (free acid)) is an S1PR modulator with selectivity for S1PR1 and S1PR4. Vonifimod modulates S1PR1 and S1PR4 through functional antagonism, inhibiting CYP2B6-mediated Bupropion (HY-B0403) hydroxylation (IC50 of 49.1 μM and 44.9 μM, respectively). Vonifimod is metabolized in human hepatocytes to the active metabolite vonifimod-phosphate and an inactive carboxylic acid metabolite. Vonifimod can be used in research related to autoimmune diseases.
