2118903-18-5
Chemical Structure
Vonifimod
Synonym(s): SLB736 free acid
- CAS No.: 2118903-18-5
- Formula:C17H34N4O2
- Molecular Weight:326.48
IUPAC Name: bis(5-methylhexyl) phthalate
InChIKey: LTSWFNFQPMMTIG-UHFFFAOYSA-N
SMILES: OCC(CO)(CCC1=CN(CCCCCCCCCC)N=N1)N
Biological Activity: Vonifimod (SLB736 (free acid)) is an S1PR modulator with selectivity for S1PR1 and S1PR4. Vonifimod modulates S1PR1 and S1PR4 through functional antagonism, inhibiting CYP2B6-mediated Bupropion (HY-B0403) hydroxylation (IC50 of 49.1 μM and 44.9 μM, respectively). Vonifimod is metabolized in human hepatocytes to the active metabolite vonifimod-phosphate and an inactive carboxylic acid metabolite. Vonifimod can be used in research related to autoimmune diseases[1].
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Vonifimod | Vonifimod (SLB736 (free acid)) is an S1PR modulator with selectivity for S1PR1 and S1PR4. Vonifimod modulates S1PR1 and S1PR4 through functional antagonism, inhibiting CYP2B6-mediated Bupropion (HY-B0403) hydroxylation (IC50 of 49.1 μM and 44.9 μM, respectively). Vonifimod is metabolized in human hepatocytes to the active metabolite vonifimod-phosphate and an inactive carboxylic acid metabolite. Vonifimod can be used in research related to autoimmune diseases. | |||||||||||||||||||||
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