Melanocortin Receptor
MC Receptor
The melanocortin (MC) receptors represent a subfamily of G-protein-coupled receptors (GPCRs) where the different subtypes are involved in a wide range of physiological functions such as pigmentation, steroid secretion, energy homeostasis, and food intake. The melanocortin receptor (MCR) family consists of five G-protein-coupled receptors (MC1R-MC5R). MC1R controls pigmentation, MC2R is a critical component of the hypothalamic-pituitary-adrenal axis, MC3R and MC4R have a vital role in energy homeostasis and MC5R is involved in exocrine function.
MCRs are activated by a variety of neuropeptides, termed melanocortins, that include the adrenocorticotropic hormone (ACTH) andα, β and γ-melanocyte-stimulating hormones (MSHs). Melanocortins derive from post-translational processing of the common polypeptide precursor pro-opiomelanocortin, expressed mainly in the hypothalamus and pituitary.
Melanocortin Receptor Isoform Specific Products
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Melanocortin Receptor Inhibitors
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Melanocortin Receptor Agonists
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Melanocortin Receptor Antagonists
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Melanocortin Receptor Activators
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Melanocortin Receptor Modulators
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Melanocortin Receptor Inducer
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Melanocortin Receptor Degrader
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Melanocortin Receptor Controls
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Melanocortin Receptor Ligands
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Melanocortin Receptor Related Products (186)
Related Products (186)
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Antibodies (2)
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Melanocortin Receptor Isoform Comparison
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PF-00446687 hydrochloride
0 ImagesCat. No.: HY-10623CAS No.: 862282-10-8PF-00446687 hydrochloride is a potent, brain-penetrating, selective melanocortin 4 receptor (MC4R) agonist with an EC50 of 12 nM. PF-00446687 hydrochloride can be used in the research of sexual dysfunction.
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Codactide
0 ImagesCat. No.: HY-P10013CAS No.: 22572-04-9Synonyms: BA-41795Codactide is a synthetic octadecapeptide, with corticotropin-like action.
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CCZ01048
0 ImagesCat. No.: HY-P2336CCZ01048, a α-melanocyte-stimulating hormone (α-MSH) analogue, exhibits high binding affinity to melanocortin 1 receptor (MC1R) with a Ki of 0.31 nM. CCZ01048 shows rapid internalization into B16F10 melanoma cells and high in vivo stability. CCZ01048 is a promising candidate for PET imaging of malignant melanoma.
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β-Corticotropin (swine)
0 ImagesCat. No.: HY-P3489CAS No.: 12427-33-7β-Corticotropin (swine) is a synthetic form of the peptide hormone corticotropin (ACTH). β-Corticotropin stimulates steroid release.
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(Phe2,Nle4)-ACTH (1-24) (human, bovine, rat)
0 ImagesCat. No.: HY-P4681CAS No.: 97773-00-7(Phe2,Nle4)-ACTH (1-24) (human, bovine, rat) is a fragment of the ACTH hormone. (Phe2,Nle4)-ACTH (1-24) (human, bovine, rat) can be labeled with I125 on Tyr23 to produce a radiolabeled ligand.
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HS014
0 ImagesCat. No.: HY-P1216CAS No.: 207678-81-7HS014 is a potent and selective melanocortin-4 (MC4) receptor antagonist, with Kis of 3.16, 108, 54.4 and 694 nM for human MC4, MC1, MC3 and MC5 receptors, respectively. HS014 modulates the behavioral effects of morphine in mice. HS014 increases food intake in free-feeding rats.
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PG106
0 ImagesCat. No.: HY-P1209CAS No.: 944111-22-2PG106 is a potent and selective human melanocortin 3 (hMC3) receptor antagonist (IC50=210 nM) and has noactivity at hMC4 receptors (EC50=9900 nM) and hMC5 receptor.
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Setmelanotide TFA
0 ImagesCat. No.: HY-19870ASynonyms: RM-493 TFA; BIM-22493 TFA; IRC-022493 TFASetmelanotide TFA (RM-493 TFA) is a blood-brain barrier-permeable, selective MC4R agonist with a Ki value of 2.1 nM for hMC4R. Setmelanotide TFA activates the CaMKK2/AMPK signaling pathway. Setmelanotide TFA mediates body weight homeostasis, feeding regulation and energy expenditure modulation; it reduces food intake, induces weight loss, decreases obesity severity, increases daytime activity and energy expenditure, lowers levels of leptin, triglycerides, fasting insulin and diastolic blood pressure, improves insulin sensitivity, glucose tolerance and fatty liver condition, and reverses respiratory depression. Setmelanotide TFA is applicable to research related to obesity, hyperinsulinemia, fatty liver and respiratory depression.
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ACTH (4-9)
0 ImagesCat. No.: HY-P3978CAS No.: 56236-83-0ACTH (4-9) is an adrenocorticotropic hormone (ACTH) fragment. ACTH (4-9) is the 4-9 sequence fragment of ACTH.
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Filimelnotide acetate
0 ImagesCat. No.: HY-P11238AFilimelnotide acetate is a melanocortin receptor agonist.
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MCL-0129
0 ImagesCat. No.: HY-123106CAS No.: 768357-45-5MCL-0129 is a compound with anxiolytic and antidepressant activity and is a selective MC4 receptor antagonist that exhibits anxiolytic and antidepressant-like behaviors in multiple rodent models.
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α-MSH (11-13)
0 ImagesCat. No.: HY-129724CAS No.: 67727-97-3Synonyms: ACTH-(11-13); Lys-Pro-Val; H-Lys-Pro-Val-OHα-MSH (11-13) (ACTH-(11-13)) is a C-terminal tripeptide of α-MSH that can cross the blood-brain barrier. α-MSH (11-13) exhibits antipyretic, anti-inflammatory, and antibacterial activities. α-MSH (11-13) also exerts neuroprotective effects after traumatic brain injury by inhibiting excessive activation of microglia and reducing neuronal apoptosis. α-MSH (11-13) can be used in research related to traumatic brain injury, fever, and bacterial infections.
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BMS-470539
0 ImagesCat. No.: HY-15616CAS No.: 457893-92-4BMS-470539 is a synthetic MC-1R agonist with potent anti-inflammatory properties. BMS-470539 selectively activates human and murine MC-1R with EC50 values ??of 16.8 nM and 11.6 nM, respectively. In vitro studies have shown that BMS-470539 is able to dose-dependently inhibit TNF-alpha-induced NF-kB activation in human melanoma cells expressing MC-1R. In vivo, subcutaneous injection of BMS-470539 into BALB/c mice effectively inhibited LPS-induced TNF-alpha production with an ED50 of approximately 10 μmol/kg and a pharmacodynamic half-life of approximately 8 hours. It also significantly reduced leukocyte infiltration in a lung inflammation model and attenuated paw swelling in a delayed-type hypersensitivity model, highlighting its efficacy as an anti-inflammatory agent through MC-1R modulation.
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ORG 31433
0 ImagesCat. No.: HY-105472CAS No.: 132031-83-5ORG 31433 is an orally active peptide related to the ACTH-(4-9) analog ORG 2766 (HY-P2113). ORG 31433 shows neuroprotective effect.
