Melanocortin Receptor
MC Receptor
The melanocortin (MC) receptors represent a subfamily of G-protein-coupled receptors (GPCRs) where the different subtypes are involved in a wide range of physiological functions such as pigmentation, steroid secretion, energy homeostasis, and food intake. The melanocortin receptor (MCR) family consists of five G-protein-coupled receptors (MC1R-MC5R). MC1R controls pigmentation, MC2R is a critical component of the hypothalamic-pituitary-adrenal axis, MC3R and MC4R have a vital role in energy homeostasis and MC5R is involved in exocrine function.
MCRs are activated by a variety of neuropeptides, termed melanocortins, that include the adrenocorticotropic hormone (ACTH) andα, β and γ-melanocyte-stimulating hormones (MSHs). Melanocortins derive from post-translational processing of the common polypeptide precursor pro-opiomelanocortin, expressed mainly in the hypothalamus and pituitary.
Melanocortin Receptor Isoform Specific Products
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Melanocortin Receptor Inhibitors
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Melanocortin Receptor Agonists
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Melanocortin Receptor Antagonists
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Melanocortin Receptor Activators
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Melanocortin Receptor Modulators
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Melanocortin Receptor Inducer
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Melanocortin Receptor Degrader
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Melanocortin Receptor Controls
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Melanocortin Receptor Ligands
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Melanocortin Receptor Related Products (186)
Related Products (186)
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Antibodies (2)
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Melanocortin Receptor Isoform Comparison
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[D-Trp8]-γ-MSH TFA
![[D-Trp8]-γ-MSH TFA](https://file.medchemexpress.com/product_pic/hy-p1217a.gif "Click to View [D-Trp8]-γ-MSH TFA Product Detail")
0 ImagesCat. No.: HY-P1217A[D-Trp8]-γ-MSH TFA is a potent and selective agonist of melanocortin 3 (MC3) receptor, with IC50s of 6.7 nM, 600 nM and 340 nM for hMC3, hMC4 and hMC5, respectively in CHO cells. [D-Trp8]-γ-MSH TFA could provide protection against multiple inflammatory disorders such as rheumatoid arthritis and colitis.
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Bivamelagon-d8
0 ImagesCat. No.: HY-153660SSynonyms: MC-4R Agonist 2-d8Bivamelagon-d8 (MC-4R Agonist 2-d8) is the deuterium labeled Bivamelagon (HY-153660). Bivamelagon (MC-4R Agonist 2) is an orally active MC4R agonist with EC50 values of 0.562 nM (Luci assay) and 36.5 nM (cAMP assay), and a Ki of 65 nM. Bivamelagon can be used for the research of diseases such as obesity and diabetes.
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Melanostatin, frog
0 ImagesCat. No.: HY-P10265CAS No.: 134709-16-3Melanostatin, frog is an inhibitor for α-melanocyte-stimulating hormone (α-MSH) release, with an IC50 of 60 nM.
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Alsactide
0 ImagesCat. No.: HY-P3553CAS No.: 34765-96-3Alsactide, a heptadecapeptide analogue, is an adrenocorticotropic hormone (ACTH) agonist. Alsactide can be used in research of central nervous system.
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DOTA-GGNle-CycMSHhex
0 ImagesCat. No.: HY-P11293CAS No.: 1309855-53-5
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Agouti-related Protein (AGRP) (83-132) Amide (human)
0 ImagesCat. No.: HY-P3561Agouti-related Protein (AGRP) (83-132) Amide (human) is a fragment of agouti-related protein (AGRP) which is a protein found in abundance in the arcuate nucleus of the hypothalamus. AgRP primarily acts as an inverse agonist for the melanocortin-4 receptor (MC4R) to increase food intake.
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IIIM-8
0 ImagesCat. No.: HY-155189CAS No.: 1128053-62-2IIIM-8 is a melanogenesis inhibitor. IIIM-8 inhibits pigment production both in vitro and in vivo without incurring any cytotoxicity in Human Adult Epidermal Melanocytes (HAEM). IIIM-8 can be used for hyperpigmentation disorders research.
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γ3-MSH
0 ImagesCat. No.: HY-P4985CAS No.: 72629-64-2γ3-MSH is derived from the N-terminal segment of pro-opiomelanocortin (POMC). γ3-MSH stimulates aldosterone secretion by human adrenal tumor cells in culture.
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Fenoprofen-13C6 sodium hydrate
0 ImagesCat. No.: HY-B1456ASSynonyms: LILLY-53858-13C6 sodium hydrateFenoprofen-13C6 (LILLY-53858-13C6) sodium hydrate is the 13C labeled Fenoprofen (HY-B1456A).Fenoprofen (LILLY-53858) is a nonsteroidal anti-inflammatory agent (NSAID) and inhibits cyclooxygenase (COX). Fenoprofen is a melanocortin receptors (MCRs) positive allosteric modulator (PAM). Fenoprofen also increases ERK1/2 activation in HEK293T cells. Fenoprofen has anti-arthritic activities and can be used for the study of rheumatoid arthritis and osteoarthritis.
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JLB2-110c
0 ImagesCat. No.: HY-P6176CAS No.: 3032608-72-0JLB2-110c activates MCRs receptor (mMC4R EC50 = 0.34 nM) and has a strong in vivo appetite suppressant effect.
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(p-Iodo-Phe7)-ACTH (4-10)
0 ImagesCat. No.: HY-P3567CAS No.: 159600-82-5(p-Iodo-Phe7)-ACTH (4-10) is a adrenocorticotrophic hormone (ACTH) derivative, which is produced and secreted by the anterior pituitary gland. (p-Iodo-Phe7)-ACTH (4-10) serves as a melanocortin (MC) receptor antagonist and inhibits α-melanocyte-stimulating hormone (α-MSH)-induced excessive grooming behavior in rats.
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ORG-2766
0 ImagesCat. No.: HY-P2113CAS No.: 50913-82-1ORG-2766 is an adrenocorticotropic hormone ACTH 4-9 analog and neurotrophic peptide. ORG-2766 affects behavioral processes such as memory and attention in animals, improving symptoms in rats with experimental allergic neuritis. ORG-2766 has a neuroprotective effect.
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CTX-1211
0 ImagesCat. No.: HY-P10985CAS No.: 1627208-75-6CTX-1211 is a selective, orally effective melanocortin MC4R agonist (EC50=0.38 nM). CTX-1211 can enhance the feeding suppression and weight loss effects induced by liraglutide (HY-P0014), and promote anorexia and weight loss activity. CTX-1211 is mainly used in the study of obesity and other metabolic disorders.
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δ-MSH
0 ImagesCat. No.: HY-P11362CAS No.: 100930-04-9δ-MSH is a melanocortin peptide. δ-MSH is a weak melanocortin receptor (MCRs) ligand.
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Chlorophorin
0 ImagesChlorophorin is a inhibitor of Melanocortin Receptor. Chlorophorin reduces tyrosinase activity and inhibits a-melanocyte-stimulating hormone-induced melanin production in B16F10 melanoma cells.
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Lys-γ3-MSH(human)
0 ImagesCat. No.: HY-P1210CAS No.: 156159-18-1Lys-γ3-MSH(human) is a melanocortin peptide derived from the C-terminal of the fragment of pro-opiomelanocortin (POMC). Lys-γ3-MSH(human) potentiates the steroidogenic response of the rat adrenal to adrenocorticotrophin (ACTH). Lys-γ3-MSH(human) is a potent stimulator of lipolysis with an apparent EC50 of 3.56 nM. Lys-γ3-MSH(human) can activate hormone sensitive lipase (HSL) and Perilipin A resulting in lipolysis.
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MC4R antagonist-2
0 ImagesCat. No.: HY-183106CAS No.: 3038478-21-3MC4R antagonist-2 is a potent melanocortin 4 receptor (MC4R) antagonist with an IC50 of 0.54 nM. MC4R antagonist-2 can be used for the research of MC4R-mediated conditions, such as cachexia, osteoporosis, neuropathic pain, depression, hypertension, malnutrition-related obesity, and associated inflammatory diseases.
