Melanocortin Receptor
MC Receptor
The melanocortin (MC) receptors represent a subfamily of G-protein-coupled receptors (GPCRs) where the different subtypes are involved in a wide range of physiological functions such as pigmentation, steroid secretion, energy homeostasis, and food intake. The melanocortin receptor (MCR) family consists of five G-protein-coupled receptors (MC1R-MC5R). MC1R controls pigmentation, MC2R is a critical component of the hypothalamic-pituitary-adrenal axis, MC3R and MC4R have a vital role in energy homeostasis and MC5R is involved in exocrine function.
MCRs are activated by a variety of neuropeptides, termed melanocortins, that include the adrenocorticotropic hormone (ACTH) andα, β and γ-melanocyte-stimulating hormones (MSHs). Melanocortins derive from post-translational processing of the common polypeptide precursor pro-opiomelanocortin, expressed mainly in the hypothalamus and pituitary.
Melanocortin Receptor Isoform Specific Products
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Melanocortin Receptor Inhibitors
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Melanocortin Receptor Agonists
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Melanocortin Receptor Antagonists
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Melanocortin Receptor Activators
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Melanocortin Receptor Modulators
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Melanocortin Receptor Inducer
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Melanocortin Receptor Degrader
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Melanocortin Receptor Controls
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Melanocortin Receptor Ligands
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Melanocortin Receptor Related Products (186)
Related Products (186)
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Antibodies (2)
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Melanocortin Receptor Isoform Comparison
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RY764
0 ImagesCat. No.: HY-111131CAS No.: 491845-95-5
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(R)-Lirinidine
0 ImagesCat. No.: HY-N2307BCAS No.: 37082-15-8Synonyms: (-)-Lirinidine(R)-Lirinidine ((-)-Lirinidine) is an aporphine-type alkaloid found in the flower buds and leaves of Nelumbo nucifera. (R)-Lirinidineand inhibits melanogenesis with an IC50 of 19.3 μM. (R)-Lirinidine exerts cytotoxic effects at 100 μM.
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Melanotan (MT)-II acetate
0 ImagesCat. No.: HY-P0267ACAS No.: 1036322-26-5Melanotan (MT)-II acetate is a melanocortin receptor agonist. Melanotan (MT)-II acetate activates melanocortin receptor 3 and melanocortin receptor 4, and stimulates the release of central endogenous oxytocin. Melanotan (MT)-II acetate reverses recognition memory impairment, increased anxiety levels and reduced exploratory tendency in zebrafish exposed to short-term high-fat diet. Melanotan (MT)-II acetate improves impaired social behavior indicators in mouse models of autism spectrum disorder. Melanotan (MT)-II acetate induces weight loss, reduces food intake and exerts anorectic effects. Melanotan (MT)-II acetate increases intracavernous pressure and erectile activity in brown rats. Melanotan (MT)-II acetate can be used in studies related to memory impairment, anxiety, reduced exploratory behavior, autism spectrum disorder, obesity and erectile dysfunction.
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Agouti-Related Protein (54-82) (human)
0 ImagesCat. No.: HY-P3924CAS No.: 209460-63-9Synonyms: AGRP (54-82) (human)Agouti-Related Protein (54-82) (human) (AGRP (54-82) (human)) is an amino-terminal 54-82 fragment of agouti-related protein (AGRP).
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MK-0489
0 ImagesCat. No.: HY-11073CAS No.: 778625-65-3MK-0489 is an orally active, highly effective, and selective MC4R agonist. MK-0489 exhibits a strong binding affinity (IC50 = 13 nM) and functional agonist activity (EC50 = 4.6 nM) at human MC4R. MK-0489 shows functional activity of 22 nM (EC50) on mouse MC4R and 1.7 μM (EC50) on mouse MC3R. MK-0489 can be used for the study of obesity.
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Cyclic MC4R peptide agonist-1
0 ImagesCat. No.: HY-P12217Cyclic MC4R peptide agonist-1 is a cyclic peptide agonist of the melanocortin-4 receptor (melanocortin-4 receptor). Cyclic MC4R peptide agonist-1 activates the human melanocortin-4 receptor via an alternative activation motif centered on APWR, and this activation process is independent of the classical HFRW pharmacophore. Cyclic MC4R peptide agonist-1 inhibits signal transduction of the human melanocortin-3 receptor and melanocortin-5 receptor. Cyclic MC4R peptide agonist-1 is used in research related to obesity.
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ACTH (3-24) (human, bovine, mouse, ovine, porcine, rabbit, rat)
0 ImagesCat. No.: HY-P3977CAS No.: 1036763-00-4ACTH (3-24) (human, bovine, mouse, ovine, porcine, rabbit, rat) is the 3-24 fragment of adrenocorticotropic hormone (ACTH). ACTH (3-24) (human, bovine, mouse, ovine, porcine, rabbit, rat) can be used for research of a variety of diseases, including cancer, immune diseases, cardiovascular disease.
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Ebiratide
0 ImagesCat. No.: HY-19648CAS No.: 105611-68-5Synonyms: HOE-427 free baseEbiratide (HOE-427 free base) is an ACTH 4-9 derivative, which acts directly on the central nervous system and exhibits memory-enhancing efficacy. Ebiratide enhances acetycholine (ACh) metabolism in rat brain.
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MSG606 TFA
0 ImagesCat. No.: HY-P1726AMSG606 TFA is a selective melanocortin 1 receptor (MC1R) antagonist. MSG606 TFA can abolish the neuroprotective effects of BMS-470539 (HY-15616) (MC1R agonist). MSG606 TFA can inhibit cancer cell proliferation and transition from the G1 to the S phase. MSG606 TFA can delay pain hypersensitivity and reduce cholesterol levels. MSG606 TFA can be used for the researches of cancer, inflammation, neurological and metabolic disease, such as breast cancer and subarachnoid hemorrhage (SAH).
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Bivamelagon hydrochloride
0 ImagesCat. No.: HY-153660ACAS No.: 2641595-55-1Synonyms: MC-4R Agonist 2 hydrochloride
