Nucleoside Antimetabolite/Analog
Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.
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Nucleoside Antimetabolite/Analog Related Products (2436)
Related Products (2436)
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3',5'-Bis-O-benzoyl-2'-deoxy-2'-fluoro-beta-D-arabino-6-azidouridine
0 ImagesCat. No.: HY-154118CAS No.: 1013470-68-23',5'-Bis-O-benzoyl-2'-deoxy-2'-fluoro-beta-D-arabino-6-azidouridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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N3-[(Tetrahydro-2-furanyl)methyl]uridine
![N3-[(Tetrahydro-2-furanyl)methyl]uridine](https://file.medchemexpress.com/product_pic/hy-152681.gif "Click to View N3-[(Tetrahydro-2-furanyl)methyl]uridine Product Detail")
0 ImagesCat. No.: HY-152681CAS No.: 122666-26-6
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9-(2-Deoxy-β-D-threo-pentofuranosyl)-9H-purin-6-amine
0 ImagesCat. No.: HY-154058CAS No.: 13276-53-49-(2-Deoxy-β-D-threo-pentofuranosyl)-9H-purin-6-amine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).
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2'-Deoxy-N2-isopropyl guanosine
0 ImagesCat. No.: HY-154428CAS No.: 201528-73-62’-Deoxy-N2-isopropyl guanosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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3’-O-Methyl-5-methyluridine
0 ImagesCat. No.: HY-154551CAS No.: 2305415-87-43’-O-Methyl-5-methyluridine is a thymidine analog. Analogs of this series have insertional activity towards replicated DNA. They can be used to label cells and track DNA synthesis.
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5'-dIMPS
0 ImagesCat. No.: HY-131815CAS No.: 771477-45-35'-dIMPS is an analogue of 5'-dIMP and a potential substrate, competitive inhibitor or regulator of enzymes that interact with 5'-dIMP.
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2-Amino-6-chloropurine-9-beta-d-(2'-deoxy-3',5'-di-o-benzoyl-2'-fluoro)arabinoriboside
0 ImagesCat. No.: HY-W605935CAS No.: 118373-61-82-Amino-6-chloropurine -9-beta-D-(2’-deoxy-3’,5’-di-O-benzoyl-2’-fluoro)arabinoriboside is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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2-Amino-2′-O-(2-methoxy-2-oxoethyl)adenosine
0 ImagesCat. No.: HY-152679CAS No.: 433288-71-22-Amino-2′-O-(2-methoxy-2-oxoethyl)adenosine is an adenosine analogue. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. The popular products in this series are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).
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N6-(4-Methoxybenzyl)-2’-C-methyl adenosine
0 ImagesCat. No.: HY-152424CAS No.: 2305415-98-7N6-(4-Methoxybenzyl)-2’-C-methyl adenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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1,2-Di-O-acetyl-3,5-di-O-benzoyl-3-beta-C-methyl-D-ribofuranose
0 ImagesCat. No.: HY-154498CAS No.: 22672-43-11,2-Di-O-acetyl-3,5-di-O-benzoyl-3-beta-C-methyl-D-ribofuranose is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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5-Fluoro-4’-thio-cytidine
0 ImagesCat. No.: HY-1526405-Fluoro-4’-thio-cytidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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2-Diethoxymethyl adenosine
0 ImagesCat. No.: HY-1542542-Diethoxymethyl adenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).
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4′-C-2-Propen-1-yluridine
0 ImagesCat. No.: HY-152463CAS No.: 66723-28-2
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4-Hydroxy-1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-2(1H)-pyridinone
0 ImagesCat. No.: HY-W547585CAS No.: 23220-74-84-Hydroxy-1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-2(1H)-pyridinone is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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5’-O-DMTr-3’-O-phthalimidopropyl cytidine
0 ImagesCat. No.: HY-1545295’-O-DMTr-3’-O-phthalimidopropyl cytidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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Trifluridine-13C,15N2
0 ImagesCat. No.: HY-A0061SCAS No.: 2086328-10-9Synonyms: Trifluorothymidine-13C,15N2; 5-Trifluorothymidine-13C,15N2; TFT-13C,15N2Trifluridine-13C,15N2 is the 13C and 15N labeled Trifluridine. Trifluridine (Trifluorothymidine;5-Trifluorothymidine;TFT) is an irreversible thymidylate synthase inhibitor, and thereby suppresses DNA synthesis. Trifluridine is an antiviral agent for herpes simplex virus (HSV) infection. Trifluorothymidine also has anti-orthopoxvirus activity.
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5'-dGMPS
0 ImagesCat. No.: HY-131814CAS No.: 87358-26-75'-dGMPS is an analogue of 5'-dGMP and a potential substrate, competitive inhibitor or regulator of enzymes that interact with 5'-dGMP.
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2'-F-2'-ara-N2-ibu-dG Phosphoramidite
0 ImagesCat. No.: HY-154606CAS No.: 1404463-20-22'-F-2'-ara-N2-ibu-dG Phosphoramidite is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7).
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2’-Deoxy-2’-fluoro-5-hydroxymethyl arabinouridine
0 ImagesCat. No.: HY-152612CAS No.: 94817-51-32’-Deoxy-2’-fluoro-5-hydroxymethyl arabinouridine is a thymidine analogue. Analogs of this series have insertional activity towards replicated DNA. They can be used to label cells and track DNA synthesis.
