Nucleoside Antimetabolite/Analog
Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.
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Nucleoside Antimetabolite/Analog Related Products (2436)
Related Products (2436)
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7-Deaza-2',3'-dideoxyadenosine
0 ImagesCat. No.: HY-138591CAS No.: 40627-30-37-Deaza-2',3'-dideoxyadenosine can be used in the synthesis of oligodeoxyribonucleotides.
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N4-Ethyl-2’-deoxycytidine
0 ImagesCat. No.: HY-154472CAS No.: 70465-61-1N4-Ethyl-2’-deoxycytidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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(S)-Ureidoglycolic acid
0 ImagesCat. No.: HY-W990361CAS No.: 7424-03-5(S)-Ureidoglycolic acid is a substrate of enzyme ureidoglycolate dehydrogenase in a purine metabolism pathway and belongs to the class of n-carbomoyl-α-amino acids.
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Phosphonoformyl-CMP
0 ImagesCat. No.: HY-180730CAS No.: 959572-49-7Synonyms: CMP-5'-Phosphonoformic acidPhosphonoformyl-CMP (CMP-5'-Phosphonoformic acid) is a nucleoside metabolite.
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2’-Chloro-N6-(4-trifluoromethyl)benzyl adenosine
0 ImagesCat. No.: HY-152337CAS No.: 722515-03-92’-Chloro-N6-(4-trifluoromethyl)benzyl adenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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3’-Azido-3’-deoxy-5-trifluoromethyluridine
0 ImagesCat. No.: HY-152708CAS No.: 2095417-62-03’-Azido-3’-deoxy-5-trifluoromethyluridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. 3’-Azido-3’-deoxy-5-trifluoromethyluridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
![2’-Deoxy-2’-fluoro-N3-[(pyrid-2-yl)methyl]uridine](https://file.medchemexpress.com/product_pic/hy-152792.gif "Click to View 2’-Deoxy-2’-fluoro-N3-[(pyrid-2-yl)methyl]uridine Product Detail")
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7-(N-Acetylaminomethyl)-7-deazaguanosine
0 ImagesCat. No.: HY-1528657-(N-Acetylaminomethyl)-7-deazaguanosine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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5’-O-TBDPS-2,2’-anhydrouridine
0 ImagesCat. No.: HY-154233CAS No.: 175013-46-45’-O-TBDPS-2,2’-anhydrouridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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2'-O-Me-5-I-U-3'-phosphoramidite
0 ImagesCat. No.: HY-1544082’-O-Me-5-I-U-3’-phosphoramidite is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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3-epi-Azido-3-deoxythymidine
0 ImagesCat. No.: HY-154697CAS No.: 73971-82-13-epi-Azido-3-deoxythymidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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Sangivamycin (Standard)
0 ImagesCat. No.: HY-118384RCAS No.: 18417-89-5Synonyms: NSC 65346 (Standard); BA-90912 (Standard)Sangivamycin (Standard) is the analytical standard of Sangivamycin. This product is intended for research and analytical applications. Sangivamycin (NSC 65346), a nucleoside analog, is a potent inhibitor of protein kinase C (PKC) with an Ki of 10 μM. Sangivamycin has potent antiproliferative activity against a variety of human cancers[1][2].
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2,3’-Anhydrothymidine
0 ImagesCat. No.: HY-154340CAS No.: 15981-92-7Synonyms: 2’-Deoxy-3’,2-anhydro-5-methyluridine2,3’-Anhydrothymidine; 2’-Deoxy-3’,2-anhydro-5-methyluridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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20-Hydroxyleukotriene E4
0 ImagesCat. No.: HY-180677CAS No.: 111844-33-8Synonyms: 20-Hydroxy-LTE420-Hydroxyleukotriene E4 (20-Hydroxy-LTE4) is a nucleoside metabolite.
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N2-iso-Butyryl-8-azaguanosine
0 ImagesCat. No.: HY-154257CAS No.: 2328168-83-6N2-iso-Butyryl-8-azaguanosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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5'-O-DMT-N2-isobutyryl-2'-O-propargylguanosine
0 ImagesCat. No.: HY-154350CAS No.: 171486-53-65'-O-DMT-N2-isobutyryl-2'-O-propargylguanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7).
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1-(2,3-Dideoxy-β-D-erythro-hexo pyranosyl)cytosine
0 ImagesCat. No.: HY-152664CAS No.: 136020-18-31-(2,3-Dideoxy-β-D-erythro-hexo pyranosyl)cytosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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2′-Deoxy-2-thiouridine
0 ImagesCat. No.: HY-154324CAS No.: 35059-12-22′-Deoxy-2-thiouridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
