Orexin Receptor (OX Receptor)
Hypocretin Receptor; HCRT Receptor
The orexin receptors (hypocretin receptors) are a family of G protein-coupled receptors and consist of orexin receptor 1 (OX1R) and orexin receptor 2 (OX2R) subtypes. Orexin receptors are expressed throughout the central nervous system and are involved in the regulation of the sleep/wake cycle.
Orexin A binding to OX1R and OX2R with similar affinity, and orexin B binding to OX2 with higher affinity than OX1R. OX1R is mainly expressed in the prefrontal and infralimbic cortex, hippocampus, paraventricular thalamic nucleus, and locus coeruleus. OX2R is mainly distributed in the cerebral cortex, septal nuclei, lateral hypothalamus, hippocampus, and hypothalamic nuclei.
Both OX1R and OX2R are coupled via Gq/11 to the activation of phospholipase C, leading to an elevation of intracellular Ca2+ levels. Moreover, OX2R also couples via Gs and Gi/o to the cAMP pathways.
Orexin Receptor (OX Receptor) Isoform Specific Products
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Orexin Receptor (OX Receptor) Inhibitors
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Orexin Receptor (OX Receptor) Agonists
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Orexin Receptor (OX Receptor) Antagonists
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Orexin Receptor (OX Receptor) Activators
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Orexin Receptor (OX Receptor) Modulators
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Orexin Receptor (OX Receptor) Related Products (130)
Related Products (130)
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Antibodies (2)
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Orexin Receptor (OX Receptor) Isoform Comparison
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ACT-335827
0 ImagesACT-335827 is a selective, orally active, brain-penetrant orexin type 1 receptor antagonist. ACT-33582 acts on OXR1 and OXR2 with IC50 values of 6 nM and 417 nM, respectively. ACT-33582 can be used in studies related to neurological disorders.
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Orexin 2 Receptor Agonist 2
0 ImagesOrexin 2 Receptor Agonist 2 is a selective orexin 2 receptor agonist, extracted from patent WO2017135306A1, example 16.
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Orexin receptor antagonist 2
0 ImagesOrexin receptor antagonist 2 (compound 30) is a potent orexin receptor antagonist with pKis of 7.69 and 9.78. Orexin receptor antagonist 2 has the potential for the research of insomnia.
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(R,R)-Suntinorexton
0 ImagesCat. No.: HY-137452APurity: 99.13%(R,R)-Suntinorexton is a isomeride of Suntinorexton (HY-137452). Suntinorexton is a orexin type 2 receptor agonist.
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(S)-YNT-3708
0 Images(S)-YNT-3708, the S-enantiomer of YNT-3708, with low activity for OX1R and OX2R (EC50 = 3595 nM and 1661 nm, respectively).
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Orexin receptor antagonist 3
0 ImagesOrexin receptor antagonist 3 (example 216) is an orexin receptor antagonist, which is extracted from the patent WO2011050198A1.
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DORA-22
0 ImagesCat. No.: HY-101260CAS No.: 1088991-95-0DORA-22 is an orally active dual orexinergic receptor antagonist, and improves the sleep disruption and memory impairment. DORA-22 can be used for study of insomnia.
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IPSU
0 ImagesIPSU is a selective, orally available and brain penetrant OX2R antagonist with a pKi of 7.85.
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Orexin B, human-13C18,15N3 TFA
0 ImagesCat. No.: HY-P1339AS1Synonyms: Human orexin B-13C18,15N3 TFAOrexin B, human-13C18,15N3 (Human orexin B-13C18,15N3) TFA is the 13C- and 15N-labeled Orexin B, human (HY-P1339). Orexin B, human is the agonist for Orexin Receptor, with Kis of 420 nM and 36 nM for OX1 and OX2. Orexin B, human participates in the regulation of appetite, wakefulness, cardiovascular function and neuroendocrine.
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MK-3697
0 ImagesMK-3697 is an orally active orexin 2 receptor (OX2R) antagonist, with an IC50 value of 16 nM and a Ki value of 1.1 nM against human OX2R. MK-3697 blocks the wake-promoting OX2R signaling pathway, reduces active wake time, and increases slow-wave sleep and rapid eye movement sleep time in mice, rats and dogs. MK-3697 can be used for research on insomnia.
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TCS-OX2-29 hydrochloride
0 ImagesCat. No.: HY-100452ACAS No.: 1610882-30-8Synonyms: OX2R antagonistTCS-OX2-29 (hydrochloride) is a potent, high affinities and selective orexin-2 receptor (OX2R) antagonist with an IC50 value of 40 nM and a pKI value of 7.5. TCS-OX2-29 displays ~250-fold selectivity for OX2 over OX1.
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GYKI-13380
0 ImagesCat. No.: HY-123176CAS No.: 75614-09-4GYKI-13380 is an appetite suppressant. GYKI-13380 has the potential for the research of neurology diseases.
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Balumorexton
0 ImagesCat. No.: HY-184054CAS No.: 3037907-48-2Balumorexton is an orally active orexin type 2 receptor (OX2R) agonist. Balumorexton is used for the research of narcolepsy.
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OX-201
0 ImagesCat. No.: HY-162712CAS No.: 2460722-03-4OX-201 is an orally active, blood-brain barrier-permeable OX2R agonist with an EC50 of 8.0 nM. OX-201 activates OX2R to induce wakefulness and neuronal activation. OX-201 promotes the release of neuron activity-dependent tau protein from neurons into the interstitial fluid of hippocampal tissues. OX-201 is applicable to research related to Alzheimer's disease and tauopathies.
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OX2-2303
0 ImagesCat. No.: HY-178871CAS No.: 1607428-33-0OX2-2303 is a potent, selective orexin-2 receptor (OX2R) antagonist. OX2-2303 exhibits excellent binding affinity towards OX2R (Ki = 0.1 nM), and shows >890-fold selectivity over OX1R. OX2-2303 can be used as a positron emission tomography (PET) radioligand for central nervous system (CNS) research.
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Orexin receptor modulator-1
0 ImagesCat. No.: HY-153458CAS No.: 2125735-57-9Orexin receptor modulator-1 is an orexin receptor modulator. Orexin receptor modulator-1 can be used for the research of substance addiction, panic disorder, anxiety, post-traumatic stress disorder, pain, depression, seasonal affective disorder, an eating disorder, or hypertension.
![[Ala11,D-Leu15]-Orexin B(human) TFA](https://file.medchemexpress.com/product_pic/hy-p1340a.gif "Click to View [Ala11,D-Leu15]-Orexin B(human) TFA Product Detail")
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Orexin 2 Receptor Agonist 3
0 ImagesCat. No.: HY-172672Orexin 2 Receptor Agonist 3 (Compound 57) is an orally active and brain-penetrant orexin receptor type-2 (OX2) agonist (EC50: 2.5 nM). Orexin 2 Receptor Agonist 3 increases wakefulness in the orexin/ataxin-3 NT1 mouse model and healthy beagle dogs. Orexin 2 Receptor Agonist 3 can be used in the study of narcolepsy.
