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Cat. No.: HY-101260

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DORA-22

Name: DORA-22
Brand: MedChemExpress
SKU: HY-101260
Price: 250.00 USD
Availability: InStock
Rating: 5 (1 reviews)

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DORA-22 is an orally active dual orexinergic receptor antagonist, and improves the sleep disruption and memory impairment. DORA-22 can be used for study of insomnia.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

Pureté: 97.67%
CAS No.: 1088991-95-0
Formule: C₂₃H₂₂F₂N₄O₂
Masse moléculaire:424.44

Stockage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

DORA-22 Chemical Structure

CAS No.: 1088991-95-0

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique

Description

DORA-22 is an orally active dual orexinergic receptor antagonist, and improves the sleep disruption and memory impairment. DORA-22 can be used for study of insomnia^[1]^[2].

Voir tous les produits spécifiques à Isoform Orexin Receptor (OX Receptor) :

Chemical Information

CAS No. 1088991-95-0
Appearance Solid
Masse moléculaire 424.44
Formule C₂₃H₂₂F₂N₄O₂
Color light brown
SMILES

FC1=CC(C(N2C[C@H](COC3=NC=C(F)C=C3)CC[C@H]2C)=O)=C(C4=NC=CC=N4)C=C1
Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Pureté et documentation

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Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (267 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Gamble MC, et al. The dual orexinergic receptor antagonist DORA-22 improves the sleep disruption and memory impairment produced by a rodent insomnia model. Sleep. 2020;43(3):zsz241. [Content Brief]

[2]. Lin Y, Ret al. Positive allosteric adenosine A2A receptor modulation suppresses insomnia associated with mania- and schizophrenia-like behaviors in mice. Front Pharmacol. 2023;14:1138666. Published 2023 Apr 19. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Concentration _(final) Concentration _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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DORA-22

Orexin A (human, rat, mouse)

SB-334867

TCS-OX2-29

JNJ-10397049

Seltorexant

Filorexant

SB-408124

EMPA

SB-674042

Seltorexant hydrochloride

Orexin 2 Receptor Agonist

Orexin B, rat, mouse

Voir tous les produits spécifiques à Isoform Orexin Receptor (OX Receptor)

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

Bioz

DORA-22

Orexin A (human, rat, mouse)

SB-334867

TCS-OX2-29

JNJ-10397049

Seltorexant

Filorexant

SB-408124

EMPA

SB-674042

Seltorexant hydrochloride

Orexin 2 Receptor Agonist

Orexin B, rat, mouse

Voir tous les produits spécifiques à Isoform Orexin Receptor (OX Receptor)

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

DORA-22 Related Classifications

HY-101260 Related Classifications

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