Orexin Receptor (OX Receptor)
Hypocretin Receptor; HCRT Receptor
The orexin receptors (hypocretin receptors) are a family of G protein-coupled receptors and consist of orexin receptor 1 (OX1R) and orexin receptor 2 (OX2R) subtypes. Orexin receptors are expressed throughout the central nervous system and are involved in the regulation of the sleep/wake cycle.
Orexin A binding to OX1R and OX2R with similar affinity, and orexin B binding to OX2 with higher affinity than OX1R. OX1R is mainly expressed in the prefrontal and infralimbic cortex, hippocampus, paraventricular thalamic nucleus, and locus coeruleus. OX2R is mainly distributed in the cerebral cortex, septal nuclei, lateral hypothalamus, hippocampus, and hypothalamic nuclei.
Both OX1R and OX2R are coupled via Gq/11 to the activation of phospholipase C, leading to an elevation of intracellular Ca2+ levels. Moreover, OX2R also couples via Gs and Gi/o to the cAMP pathways.
Orexin Receptor (OX Receptor) Isoform Specific Products
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Orexin Receptor (OX Receptor) Inhibitors
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Orexin Receptor (OX Receptor) Agonists
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Orexin Receptor (OX Receptor) Antagonists
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Orexin Receptor (OX Receptor) Activators
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Orexin Receptor (OX Receptor) Modulators
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Orexin Receptor (OX Receptor) Related Products (130)
Related Products (130)
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Antibodies (2)
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Orexin Receptor (OX Receptor) Isoform Comparison
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Orexin B, human-13C6,15N TFA
0 ImagesCat. No.: HY-P1339ASSynonyms: Human orexin B-13C6,15N TFAOrexin B, human-13C6,15N (Human orexin B-13C6,15N) TFA is the 13C- and 15N-labeled Orexin B, human (HY-P1339). Orexin B, human is the agonist for Orexin Receptor, with Kis of 420 nM and 36 nM for OX1 and OX2. Orexin B, human participates in the regulation of appetite, wakefulness, cardiovascular function and neuroendocrine.
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Ledasorexton
0 ImagesCat. No.: HY-177096CAS No.: 2758363-88-9Ledasorexton is an orally active OX2R agonist (EC50: 0.99 nM). Ledasorexton has awakening effect in mice. Ledasorexton can be used for research of neurological disease.
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Orexin receptor activator-1
0 ImagesCat. No.: HY-162977CAS No.: 3038645-77-8Orexin receptor activator-1 is an Orexin Receptor agonist. Orexin receptor activator-1 can be used to study orexin-related diseases.
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SHR-1806
0 ImagesCat. No.: HY-P992462SHR-1806 is a OX40 agonist and a NF-κB activator, with antitumor activity. SHR-1806 mediates ADCC and CDC effects, enhances the function and expansion of effector T cells, suppresses regulatory T cells, and increases γ-interferon secretion. SHR-1806 exhibits typical pharmacokinetic characteristics and favorable safety profiles. SHR-1806 can be used in studies related to solid tumors and colon cancer.
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OX2R-IN-3
0 ImagesCat. No.: HY-161567CAS No.: 2791360-37-5OX2R-IN-3 (Compound 53) is an orally active type 2 orexin receptor (OX2R) agonist (EC50<100 nM.).
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Hypocretin (70-98), human
0 ImagesCat. No.: HY-P3867CAS No.: 1129545-33-0Hypocretin (70-98), human is a polypeptide that is capable of binding to an orexin receptor OX1R and promotes apoptosis.
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ZL-1101
0 ImagesCat. No.: HY-P991339ZL-1101 is a human monoclonal antibody (mAb) targeting TNFRSF4/OX40/CD134.
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Amlitelimab (FUT8-KO)
0 ImagesCat. No.: HY-P99434AAmlitelimab (FUT8-KO) is Amlitelimab (HY-P99434) expressed in cells with the fucosyltransferase 8 gene (FUT8) knocked out. Amlitelimab (KY1005) is a monoclonal antibody (mAb) against OX40 ligand (OX40L). Amlitelimab inhibits the OX40-OX40L interaction and can be used for research on atopic dermatitis.
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YNT-3708
0 ImagesCat. No.: HY-171032BCAS No.: 2923137-99-7YNT-3708 is an orexin receptor (OXR) agonist, with EC50 values of 14.6 nM and 277 nm for OX1R and OX2R, respectively.
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Orexin A-13C5,15N (human, rat, mouse) TFA
0 ImagesCat. No.: HY-106224ASSynonyms: Hypocretin-1-13C6,15N (human, rat, mouse) TFAOrexin A-13C6,15N (human, rat, mouse) (Hypocretin-1-13C6,15N (human, rat, mouse)) TFA is the 13C- and 15N-labeled Orexin A (human, rat, mouse) (HY-106224). Orexin A (human, rat, mouse) (Hypocretin-1 (human, rat, mouse)), a 33 amino acid excitatory neuropeptide, orchestrates diverse central and peripheral processes. Orexin A (human, rat, mouse) binds and activates two types of G protein-coupled receptors, the orexin-1 receptor (OX1R) and the orexin-2 receptor (OX2R). Orexin A (human, rat, mouse) has a role in the regulation of feeding behavior. Orexin A (human, rat, mouse) is an effective anti-nociceptive and anti-hyperalgesic agent in mice and rats.
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Fumiporexant
0 ImagesCat. No.: HY-177085CAS No.: 2839408-03-4Fumiporexant (Compound Example 93) is an orally active, brain-penetrant and selective Orexin receptor 2 (OX2R) antagonist. Fumiporexant regulates the sleep-wake cycle and emotion-related pathways in the central nervous system. Fumiporexant is promising for research of nervous system diseases such as insomnia and major depressive disorder.
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Xenopus orexin A
0 ImagesCat. No.: HY-P10079CAS No.: 254757-77-2Xenopus orexin A is a neuropeptides that identified as an endogenous ligands for an orphan G-protein-coupled receptor. Xenopus orexin A is a potent agonist of OX1R.
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Orexin receptor antagonist 4
0 ImagesCat. No.: HY-146517CAS No.: 2251017-69-1Orexin receptor antagonist 4 is potent and selective orexin 2 receptor (OX2R) antagonist with an IC50 of 4.27 nM. Orexin receptor antagonist 4 is 61-fold selective for the OX2R over the OX1R (IC50 of 295 nM) (WO2018206959A1; example 1).
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Anti-OX2R/CD200R1 Antibody
0 ImagesCat. No.: HY-P990479
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Xenopus orexin B
0 ImagesCat. No.: HY-P10080CAS No.: 254757-78-3Xenopus orexin B is a neuropeptides that identified as an endogenous ligands for an orphan G-protein-coupled receptor. Xenopus orexin B is a potent agonist of OX2R.
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Orexin A (16-33)
0 ImagesCat. No.: HY-P4792CAS No.: 1374694-00-4Orexin A (16-33) is a fragment of orexin A.
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Orexin B, human
0 ImagesCat. No.: HY-P1339CAS No.: 205640-91-1Synonyms: Human orexin BOrexin B, human is an endogenous agonist at Orexin receptor with Kis of 420 and 36 nM for OX1 and OX2, respectively.
