Ledasorexton
Ledasorexton is an orally active OX2R agonist (EC50: 0.99 nM). Ledasorexton has awakening effect in mice. Ledasorexton can be used for research of neurological disease.
For research use only. We do not sell to patients.
- CAS No.: 2758363-88-9
- Formula: C22H32FN5O2
- Molecular Weight:417.52
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Orexin Receptor (OX Receptor) Isoforms
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Biological Activity
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OX2 Receptor 0.99 nM (EC50) |
OX1 Receptor >100 nM (EC50) |
Ledasorexton (Example 1) exhibits potent agonist activity against hOX2R with an EC50 of 0.99 nM, while showing weak activity against hOX1R (EC50 > 100 nM) in HEK293 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Orexin/ataxin-3 Tg mice (10-14 weeks old)[1]
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Dosage:0.3, 1, and 3 mg/kg
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Administration:i.g., single dose
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Result:Significantly prolonged sleep latency at 1 and 3 mg/kg.
Significantly suppressed cataplexy-like symptoms at 3 mg/kg.
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Animal Model:Male wild-type (WT) C57BL/6 mice (13 weeks old)[1]
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Dosage:1, 3 and 10 mg/kg
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Administration:i.g., single dose
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Result:Significantly increased spontaneous activity in mice.
Significantly increased sleep latency at 3 or 10 mg/kg.
Chemical Information
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CAS No. 2758363-88-9
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Molecular Weight 417.52
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Formula C22H32FN5O2
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SMILES
NC([C@@H](C1CC1)N2[C@@]3([H])C[C@]([C@]4([H])[C@@H](CN(C5=NC=C(F)C=N5)CC4)OC)([H])C[C@]2([H])CC3)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Ledasorexton Related Classifications
HY-177096 Related Classifications
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