PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
All Product Categories
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PROTAC Linkers Related Products (4102)
Related Products (4102)
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PROTAC Linkers Isoform Comparison
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6-Bromohexanoyl Chloride
0 ImagesCat. No.: HY-W540231CAS No.: 22809-37-6
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tert-Butyl (2-((tert-butyldimethylsilyl)oxy)ethyl)carbamate
0 ImagesCat. No.: HY-W068370CAS No.: 203738-69-6
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Sebacic acid monomethyl ester
0 ImagesCat. No.: HY-W150022CAS No.: 818-88-2
![PIP-C-3-Azaspiro[5.5]undecane-boc](https://file.medchemexpress.com/product_pic/hy-161656.gif "Click to View PIP-C-3-Azaspiro[5.5]undecane-boc Product Detail")
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Tert-butyl (4-((tert-butoxycarbonyl)amino)phenethyl)carbamate
0 ImagesCat. No.: HY-W353135CAS No.: 1823291-67-3
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Fmoc-NH-PEG15-CH2CH2COOH
0 ImagesCat. No.: HY-133361CAS No.: 2378590-46-4
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Ethyl 3-aminopropanoate
0 ImagesCat. No.: HY-W243057CAS No.: 924-73-2
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Ethyl 3-(4-(hydroxymethyl)phenyl)propanoate
0 ImagesCat. No.: HY-W105460CAS No.: 107859-98-3
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Ethyl 5-bromo-4-oxopentanoate
0 ImagesCat. No.: HY-W320948CAS No.: 14594-25-3
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19-Hydroxynonadecanoic acid
0 ImagesCat. No.: HY-W614815CAS No.: 22438-61-5
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Boc-PEG3-O-methyl acetate
0 ImagesCat. No.: HY-W567494CAS No.: 2100306-59-8
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Methyl 4-((tert-butoxycarbonyl)amino)butanoate
0 ImagesCat. No.: HY-W101725CAS No.: 85909-04-2
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Tert-butyl (3-cyanopropyl)(methyl)carbamate
0 ImagesCat. No.: HY-W395458CAS No.: 1379225-92-9
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3-[Benzyl(methyl)amino]propanoic acid
![3-[Benzyl(methyl)amino]propanoic acid](https://file.medchemexpress.com/product_pic/hy-w151576.gif "Click to View 3-[Benzyl(methyl)amino]propanoic acid Product Detail")
0 ImagesCat. No.: HY-W151576CAS No.: 149692-49-9
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H2N-PEG2-CH2COOtBu hydrochloride
0 ImagesCat. No.: HY-135927ACAS No.: 2098500-69-5
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m-PEG12-Br
0 ImagesCat. No.: HY-141378CAS No.: 1620461-89-3
