PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
All Product Categories
-
PROTAC Linkers Related Products (4102)
Related Products (4102)
-
PROTAC Linkers Isoform Comparison
-
3-Aminophenol-PEG4-methyl
0 ImagesCat. No.: HY-134742CAS No.: 1429340-32-8
-
Ald-Ph-PEG12-TFP ester
0 ImagesCat. No.: HY-140624CAS No.: 3031166-52-3
-
Propargyl-PEG4-5-nitrophenyl carbonate
0 ImagesPropargyl-PEG4-5-nitrophenyl carbonate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG4-5-nitrophenyl carbonate is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
-
Bis-PEG4-sulfonic acid
0 ImagesCat. No.: HY-140166CAS No.: 1807539-08-7
-
Tos-aminoxy-Boc-PEG4-Tos
0 ImagesCat. No.: HY-140380CAS No.: 1817735-42-4
-
m-PEG7-azide
0 ImagesCat. No.: HY-130561CAS No.: 208987-04-6m-PEG7-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. m-PEG7-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
-
BOC-NH-PEG2-propene
0 ImagesCat. No.: HY-138398CAS No.: 2410236-85-8
-
Biotin-PEG2-NH-Boc
0 ImagesCat. No.: HY-140934CAS No.: 175885-18-4
-
DBCO-NHCO-PEG4-acid
0 ImagesCat. No.: HY-125541CAS No.: 1870899-46-9DBCO-Amide-PEG5-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-Amide-PEG5-acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). DBCO-NHCO-PEG4-acid is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
-
N-Mal-N-bis(PEG2-C2-Boc)
0 ImagesCat. No.: HY-140576CAS No.: 2100306-51-0
-
Ald-CH2-PEG5-Boc
0 ImagesCat. No.: HY-130330CAS No.: 1446282-23-0
-
m-PEG17-NHS ester
0 ImagesCat. No.: HY-141108CAS No.: 3081957-14-1
![2-[4-(Aminomethyl)triazol-1-yl]ethanamine](https://file.medchemexpress.com/product_pic/hy-178198.gif "Click to View 2-[4-(Aminomethyl)triazol-1-yl]ethanamine Product Detail")
-
N-Benzyl-N-bis-PEG4
0 ImagesCat. No.: HY-140587CAS No.: 1680183-01-0
-
CH2COOH-PEG9-CH2COOH
0 ImagesCat. No.: HY-138514CAS No.: 2250056-46-1
-
Hydroxy-PEG3-PFP ester
0 ImagesCat. No.: HY-141212CAS No.: 1807537-40-1Synonyms: Pentafluorophenyl 3-{2-[2-(2-hydroxyethoxy)ethoxy]ethoxy}propanoate
