Trk Receptor Degrader
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PROTAC NTRK1 degrader-1
0 ImagesCat. No.: HY-181052CAS No.: 2922274-35-7PROTAC NTRK1 degrader-1 is a wild-type and mutant NTRK1 PROTAC degrader with IC50 values of 4 nM (wild-type), 2 nM (G595R), 5 nM (G667C), and <0.5 nM (F598L). PROTAC NTRK1 degrader-1 catalyzes ubiquitination and subsequent proteasome-mediated degradation of wild-type and mutant (G595R, G667C, F598L) NTRK1. PROTAC NTRK1 degrader-1 can be used for the research of solid tumors.
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JWJ-01-378
0 ImagesCat. No.: HY-175271JWJ-01-378 is a TPM3-TRKA fusion protein inhibitor and a wild-type TRK PROTAC degrader. JWJ-01-378 induces degradation via the ubiquitin-proteasome system, and does not degrade TRK inhibitor-resistant mutants or ALK fusion proteins. JWJ-01-378 inhibits downstream signaling pathways activated by TPM3-TRKA fusion, and reduces the viability of cancer cells harboring TPM3-TRKA fusion. JWJ-01-378 can be used to evaluate targeted degradation of TRK fusion proteins in cancer.
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Sovutrecdeg
0 ImagesCat. No.: HY-187906CAS No.: 2412058-69-4Sovutrecdeg is a tropomyosin receptor kinase (TRK) degrader with antitumor activity. Sovutrecdeg can be used in tumor-related research.
