Xanthine Oxidase
XO
Xanthine oxidase (XO), a versatile molybdoflavoprotein, catalyzes the oxidative hydroxylation of purine substrates (hypoxanthine and xanthine) to produce uric acid and subsequent reduction of oxygen at the flavin center with the generation of reactive oxygen species, either superoxide anion radical or hydrogen peroxide.
Xanthine oxidase is an important enzyme of purine catabolism pathway and has been associated directly in pathogenesis of gout and indirectly in many pathological conditions like cancer, diabetes and metabolic syndrome. The selective inhibition of xanthine oxidase may result in a broad spectrum therapeutic use for gout, cancer, inflammation and oxidative damage.
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Xanthine Oxidase Related Products (159)
Related Products (159)
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Antibodies (1)
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Hydroxyakalone
0 ImagesCat. No.: HY-N14777CAS No.: 182056-35-5Hydroxyakalone is an inhibitor of Xanthosine oxidase (XOD, EC 1.2.3.2), with an IC50 of 4.6 μM.
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Amflutizole
0 ImagesCat. No.: HY-119955CAS No.: 82114-19-0Synonyms: LY-141894Amflutizole (LY-141894) is an inhibitor of xanthine oxidase. Amflutizole abolishes free radical formation and release in cerebral ischemia/reperfusion mice.
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Xanthine oxidase-IN-14
0 ImagesCat. No.: HY-W560574CAS No.: 80025-67-8Xanthine oxidase-IN-14 (Compound 3f) is an inhibitor for xanthine oxidase, with IC50 >100 μM. Xanthine oxidase-IN-14 inhibits proliferations of cancer cells MCF-7, NCI-H460 and SF-268, with IC50 greater than 150 μM.
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Oxypurinol-13C,15N2-1
0 ImagesCat. No.: HY-W777649CAS No.: 1217036-71-9Synonyms: Oxipurinol-13C,15N2-1Oxypurinol-13C,15N2-1 (Oxipurinol-13C,15N2-1) is 15N and 13C labeled Oxypurinol (HY-19657). Oxipurinol, the major active metabolite of Allopurinoll (HY-B0219), is an inhibitor of xanthine oxidase. Oxipurinol can be used to regulate blood urate levels and treat gout.
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Xanthine oxidase-IN-22
0 ImagesCat. No.: HY-181095CAS No.: 3075445-37-0Xanthine oxidase-IN-22 is an orally active inhibitor of xanthine oxidase (XO) (IC50: 0.0034 μM). Xanthine oxidase-IN-22 exhibits a mixed-type inhibition mode against XO. Xanthine oxidase-IN-22 reduces serum uric acid levels in mice. Xanthine oxidase-IN-22 can be used in research related to hyperuricemia and gout.
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Nequinate (Standard)
0 ImagesCat. No.: HY-116433RCAS No.: 13997-19-8Nequinate (Standard) is the analytical standard of Nequinate. This product is intended for research and analytical applications. Nequinate, a quinoline compound, is an anticoccidial agent against cecal coccidiosis (Eimeria tenella) infections. Nequinate inhibits xanthine oxidoreductase (XOD) activity.
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4-Nitrocinnamic acid (Standard)
0 ImagesCat. No.: HY-W015069RCAS No.: 619-89-64-Nitrocinnamic acid (Standard) is the analytical standard of 4-Nitrocinnamic acid (HY-W015069). This product is intended for research and analytical applications. 4-Nitrocinnamic acid is a Phenylpropanoids product that can be isolated from the heartwoods of Cassia garrettiana.
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5,6,7-Trihydroxy-4'-methoxyflavone
0 Images5,6,7-Trihydroxy-4'-methoxyflavone (4'-O-Methylscutellarein) is a flavonoid and a weak inhibitor of xanthine oxidase. 5,6,7-Trihydroxy-4'-methoxyflavone possesses antithrombotic and antioxidant activities. 5,6,7-Trihydroxy-4'-methoxyflavone has an IC50 value of 25.29 µM for DPPH free radical scavenging. 5,6,7-Trihydroxy-4'-methoxyflavone can also inhibit H2O2-induced damage to PC12 cells. 5,6,7-Trihydroxy-4'-methoxyflavone is applicable for the research of diseases such as cerebrovascular disorders.
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Digallic acid
0 ImagesDigallic acid is an antioxidant, antimutagenic, antigenotoxic, and anti-hyperuricemic compound. Digallic acid is a reverse transcriptase and XOD, URAT1 (IC50: 5.34 μM) inhibitor. Digallic acid scavenges DPPH· and O2·− radicals. Digallic acid induces apoptosis. Digallic acid can be isolated from the fruits of Pistascia lentiscus.
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Azapropazone (Standard)
0 ImagesCat. No.: HY-116442RCAS No.: 13539-59-8Azapropazone (Standard) is the analytical standard of Azapropazone (HY-116442). This product is intended for research and analytical applications. Azapropazone is an orally active nonsteroidal anti-inflammatory agent. Azapropazone inhibits Xanthine oxidase activity with an IC50 of 70-140 μg/mL. Azapropazone exerts significant cardiomyocyte protective effects on dogs with ischemia-reperfusion injury. Azapropazone reduces arthritis. Azapropazone inhibits Adrenaline-induced platelet aggregation. Azapropazone can be used for the research of myocardial ischemia and reperfusion injury, adjuvant arthritis, and gouty arthritis.
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Xanthine oxidase-IN-1
0 ImagesCat. No.: HY-U00288CAS No.: 1071970-13-2Synonyms: 4-(3-Cyano-5,6-difluoroindol-1-yl)-2-hydroxybenzoic acidXanthine oxidase-IN-1 is a xanthine oxidase inhibitor extracted from patent WO2008126898A1, page 68, compound example 3, with an IC50 of 6.5 nM.
