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Cat. No.: HY-181095

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Xanthine oxidase-IN-22

Xanthine oxidase-IN-22 is an orally active inhibitor of xanthine oxidase (XO) (IC₅₀: 0.0034 μM). Xanthine oxidase-IN-22 exhibits a mixed-type inhibition mode against XO. Xanthine oxidase-IN-22 reduces serum uric acid levels in mice. Xanthine oxidase-IN-22 can be used in research related to hyperuricemia and gout.

For research use only. We do not sell to patients.

CAS No.: 3075445-37-0
Formula: C₁₈H₁₇N₇O₂
Molecular Weight:363.37

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Xanthine oxidase-IN-22 Chemical Structure

CAS No.: 3075445-37-0

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vivo

Xanthine oxidase-IN-22 (Compound B33) (5 mg/kg; p.o.; single dose) exhibits significant uric acid-lowering activity in hyperuricemic mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Hyperuricemic mice (male, 22-25 g)^[1]
Dosage:

5 mg/kg
Administration:

p.o.; single dose
Result:

Reduced serum uric acid level by 51.9% at 5 h post treatment compared to the model group.

Chemical Information

CAS No. 3075445-37-0
Molecular Weight 363.37
Formula C₁₈H₁₇N₇O₂
SMILES

CC1=CC(C)=CC(C)=C1NC2=CC(C#N)=NC(N3N=CC(C(O)=O)=C3N)=N2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wang H, et al. Discovery of 1-(4-cyanopyrimidin-2-yl)-1H-pyrazole-4-carboxylic acids as potent xanthine oxidase inhibitors via molecular cleavage and reassembly of allopurinol as a key strategy. Bioorg Chem. 2026;170:109481. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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