Xanthine Oxidase
XO
Xanthine oxidase (XO), a versatile molybdoflavoprotein, catalyzes the oxidative hydroxylation of purine substrates (hypoxanthine and xanthine) to produce uric acid and subsequent reduction of oxygen at the flavin center with the generation of reactive oxygen species, either superoxide anion radical or hydrogen peroxide.
Xanthine oxidase is an important enzyme of purine catabolism pathway and has been associated directly in pathogenesis of gout and indirectly in many pathological conditions like cancer, diabetes and metabolic syndrome. The selective inhibition of xanthine oxidase may result in a broad spectrum therapeutic use for gout, cancer, inflammation and oxidative damage.
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Xanthine Oxidase Related Products (159)
Related Products (159)
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Antibodies (1)
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Xanthine oxidase-IN-18
0 ImagesCat. No.: HY-178342Xanthine oxidase-IN-18 is a potent orally activeXanthine oxidase (XO) inhibitor (IC50 = 0.263 μM). Xanthine oxidase-IN-18 exerts inhibition by directly and stably binding to the xanthine oxidase Mo-co active site. Xanthine oxidase-IN-18 exhibits reactive oxygen species (ROS) scavenging activity. Xanthine oxidase-IN-18 shows anti-hyperuricemia effects in a Potassium oxonate (HY-17511)-induced hyperuricemic rat model. Xanthine oxidase-IN-18 can be used for hyperuricemia, breast and lung cancer research.
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Oxypurinol-13C3,15N3
0 ImagesCat. No.: HY-19657S1Synonyms: Oxipurinol-13C3,15N3Oxypurinol-13C3,15N3 (Oxipurinol-13C3,15N3) is the 13C- and 15N-labeled Oxypurinol (HY-19657). Oxipurinol (Oxipurinol), the major active metabolite of Allopurinol, is an inhibitor of xanthine oxidase. Oxipurinol can be used to regulate blood urate levels and treat gout.
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Forsythoside F
0 ImagesSynonyms: ArenariosideForsythoside F (Arenarioside) is a xanthine oxidase inhibitor and possesses antihyperuricemic effects in vivo.
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Xanthine oxidase-IN-17
0 ImagesCat. No.: HY-175303CAS No.: 185522-92-3Xanthine oxidase-IN-17 is a potent xanthine oxidase (XOD) inhibitor with an IC50 of 298 nM and a Ki of 167 nM. Xanthine oxidase-IN-17 decreases the formation of O₂⁻ radical by inhibiting the catalytic activity of XOD to diminish the production of uric acid. Xanthine oxidase-IN-17 shows no cytotoxicity in AML-12 hepatocytes, while suppressing uric acid production. Xanthine oxidase-IN-17 can be used for the studies of hyperuricemia and subsequently to gout.
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Xanthine oxidase-IN-12
0 ImagesCat. No.: HY-156360CAS No.: 3041062-80-7Xanthine oxidase-IN-12 (Compound 11) is a xanthine oxidase (XO) inhibitor with an IC50 of 91 nM. Xanthine oxidase-IN-12 also has antioxidant activity and reduces intracellular ROS.
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XOR/URAT1-IN-1
0 ImagesCat. No.: HY-161523CAS No.: 2810137-86-9XOR/URAT1-IN-1 (Compound II15) is a dual inhibitor for xanthine oxidoreductase (XOR) and uric acid transporter 1 (URAT1), with IC50 of 6 nM and 12.9 μM. XOR/URAT1-IN-1 lowers the levels of uric acid in Potassium oxonate (HY-17511)/Hypoxanthine (HY-N0091)-induced acute hyperuricemia mouse model.
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Eupatoriochromene
0 ImagesEupatoriochromene is a chromene and has inhibitory activity against xanthine oxidase (XO).
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Baicalein 6-O-glucoside
0 ImagesCat. No.: HY-N8352CAS No.: 28279-72-3Baicalein 6-O-glucoside is a glucuronidation metabolite of Baicalein.
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Xanthine oxidase-IN-8
0 ImagesCat. No.: HY-N10432CAS No.: 2571069-66-2Synonyms: Icarisids JXanthine oxidase-IN-8 (Icarisids J) (Compound 7) is a XOD inhibitor with an IC50 of 29.71 μM.
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Angexostat
0 ImagesCat. No.: HY-177070CAS No.: 2640653-91-2Angexostat (Compound 2) is an inhibitor of xanthine oxidase. Angexostat exhibits high permeability. Angexostat inhibits CYP2C9 with an IC50 of 18.1 μM. Angexostat can be studied in research for xanthine oxidase-related diseases such as hyperuricemia and gout.
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Xanthine oxidase-IN-6
0 ImagesCat. No.: HY-146560Xanthine oxidase-IN-6 (Compound 6c) is a potent, orally active, mixed-type xanthine oxidase (XOD) inhibitor with an IC50 value of 1.37 µM. Xanthine oxidase-IN-6 shows strong anti-hyperuricemia and renal protective activity.
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XO/COX/LOX-IN-1
0 ImagesCat. No.: HY-151173CAS No.: 2831329-35-0XO/COX/LOX-IN-1 is a XO/COX/LOX inhibitor with an IC50 of 3.2 μM against rat XO, 10.83 μM against 5-LOX, 12.67 μM against COX-1, and 8.31 μM against COX-2. XO/COX/LOX-IN-1 binds to the active sites of XO, 5-LOX, COX-1 and COX-2, thereby blocking enzyme activities associated with uric acid, leukotriene, prostaglandin synthesis and inflammatory pathways. XO/COX/LOX-IN-1 can be used in the research of hyperuricemia and inflammation.
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Xanthine oxidoreductase-IN-4
0 ImagesCat. No.: HY-151974CAS No.: 1026587-58-5Xanthine oxidoreductase-IN-4 is an orally active xanthine oxidoreductase (XOR) inhibitor. Xanthine oxidoreductase-IN-4 has inhibitory activity against XOR with an IC50 value of 29.3 nM. Xanthine oxidoreductase-IN-4 can be used for the research of hyperuricemia.
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Ellagic acid 4-O-β-D-xylopyranoside
0 ImagesCat. No.: HY-N10741CAS No.: 139163-18-1Ellagic acid 4-O-β-D-xylopyranoside is a natural ellagitannin with antimicrobial activity. Ellagic acid 4-O-β-D-xylopyranoside is an xanthine oxidase inhibitor with an 50 of 2.1 μg/mL.
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Xanthine oxidase-IN-10
0 ImagesCat. No.: HY-150257CAS No.: 851429-65-7Xanthine oxidase-IN-10 (XO8 analog) is an xanthine oxidase (XO) inhibitor.
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(+/-)-Epicatechin
0 ImagesCat. No.: HY-W104467CAS No.: 13392-26-2Synonyms: (+/-)-Epicatechol; (+/-)-epi-Catechin(+/-)-Epicatechin is a xanthine oxidase inhibitor with an IC50 of 982.14 μM, and can be found in Semen Plantaginis (Plantago seed). (+/-)-Epicatechin can be used in research on diseases such as hyperuricemia and gout .
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Tetrahydroamentoflavone
0 ImagesCat. No.: HY-N1162CAS No.: 48236-96-0Synonyms: AmentoflavanoneTetrahydroamentoflavone (Amentoflavanone) is a potent xanthine oxidase (XO) inhibitor. Tetrahydroamentoflavone has inhibitory activity for XO with IC50 and Ki values of 92 nM and 0.982 μM, respectively. Tetrahydroamentoflavone can be used for the research of inflammatory disorders and gout.
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Xanthine oxidase-IN-9
0 ImagesCat. No.: HY-N10433CAS No.: 2571069-61-7Synonyms: Icarisids EXanthine oxidase-IN-9 (Icarisids E) (Compound 2) is a potent xanthine oxidase (XOD) inhibitor with an IC50 of 31.81 μM.
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Morin 3-O-β-D-glucopyranoside
0 ImagesCat. No.: HY-N10411CAS No.: 1169766-14-6Morin 3-O-β-D-glucopyranoside is a natural flavonoid with antifungal, anticancer and antioxidant activities. Morin 3-O-β-D-glucopyranoside inhibits reverse transcriptase, protein-tyrosine kinase and xanthine oxidase, and also shows anti-HIV, antiarteriosclerotic, and superoxide scavenging activities.
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2-Methylacetophenone (Standard)
0 ImagesSynonyms: O-Methylacetophenone (Standard)2-Methylacetophenone (O-Methylacetophenone) (Standard) is the analytical standard of 2-Methylacetophenone (HY-W012658). This product is intended for research and analytical applications. 2-Methylacetophenone (O-Methylacetophenone), acetophenone derivative and acaricide, is a xanthine dehydrogenase (XDH) inhibitor. 2-Methylacetophenone competitively binds to the XDH active site, blocking the pathway for xanthine to be converted to uric acid. 2-Methylacetophenone can be used for the study of hyperuricemia and house dust.
