13539-59-8
Chemical Structure
Azapropazone
- CAS No.: 13539-59-8
- Formula:C16H20N4O2
- Molecular Weight:300.36
IUPAC Name: 5-(dimethylamino)-9-methyl-2-propyl-1H-benzo[e]pyrazolo[1,2-a][1,2,4]triazine-1,3(2H)-dione
InChIKey: MPHPHYZQRGLTBO-UHFFFAOYSA-N
SMILES: O=C1C(C(N2N1C(N(C)C)=NC3=CC=C(C=C32)C)=O)CCC
Biological Activity: Azapropazone is an orally active nonsteroidal anti-inflammatory agent. Azapropazone inhibits Xanthine oxidase activity with an IC50 of 70-140 μg/mL. Azapropazone exerts significant cardiomyocyte protective effects on dogs with ischemia-reperfusion injury. Azapropazone reduces arthritis. Azapropazone inhibits Adrenaline-induced platelet aggregation. Azapropazone can be used for the research of myocardial ischemia and reperfusion injury, adjuvant arthritis, and gouty arthritis[1][2][3].
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Azapropazone | 99.67% | Azapropazone is an orally active nonsteroidal anti-inflammatory agent. Azapropazone inhibits Xanthine oxidase activity with an IC50 of 70-140 μg/mL. Azapropazone exerts significant cardiomyocyte protective effects on dogs with ischemia-reperfusion injury. Azapropazone reduces arthritis. Azapropazone inhibits Adrenaline-induced platelet aggregation. Azapropazone can be used for the research of myocardial ischemia and reperfusion injury, adjuvant arthritis, and gouty arthritis. | ||||||||||||||||||||
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Azapropazone (Standard) | ≥98% | Azapropazone (Standard) is the analytical standard of Azapropazone (HY-116442). This product is intended for research and analytical applications. Azapropazone is an orally active nonsteroidal anti-inflammatory agent. Azapropazone inhibits Xanthine oxidase activity with an IC50 of 70-140 μg/mL. Azapropazone exerts significant cardiomyocyte protective effects on dogs with ischemia-reperfusion injury. Azapropazone reduces arthritis. Azapropazone inhibits Adrenaline-induced platelet aggregation. Azapropazone can be used for the research of myocardial ischemia and reperfusion injury, adjuvant arthritis, and gouty arthritis. | ||||||||||||||||||||
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References
- [1]. Mousa SA, et al. Myocardial cytoprotective efficacy of azapropazone in a canine heart model of regional ischemia and reperfusion. J Cardiovasc Pharmacol. 1989;14(4):542-548. [Content Brief]
- [2]. Rainsford KD, et al. Comparative effects of azapropazone on cellular events at inflamed sites. Influence on joint pathology in arthritic rats, leucocyte superoxide and eicosanoid production, platelet aggregation, synthesis of cartilage proteoglycans, synovial production and actions of interleukin-1 in cartilage resorption correlated with drug uptake into cartilage in-vitro. J Pharm Pharmacol. 1989;41(5):322-330. [Content Brief]
- [3]. Mackin WM, et al. Inhibition of rat neutrophil functional responses by azapropazone, an anti-gout drug. Biochem Pharmacol. 1986;35(6):917-922. [Content Brief]
