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Cat. No.: HY-W009640A

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Mofebutazone sodium

Mofebutazone sodium is a pyrazolidinedione non-steroidal anti-inflammatory agent (NSAID). Mofebutazone sodium exhibits weak COX inhibition, no effect on LOX, and slightly suppresses the percentage of leukocyte phagocytosis in vitro. Mofebutazone sodium can be used in research related to soft tissue rheumatism.

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CAS No.: 41468-34-2
화학식: C₁₃H₁₅N₂NaO₂
분자량:254.26

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Mofebutazone sodium Chemical Structure

CAS No.: 41468-34-2

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All COX Isoforms :

In Vitro

Innate ImmunityBacterial InfectionOxidative StressLipid Inflammatory MediatorsLipid Metabolism

Innate Immunity

Bacterial Infection

Mofebutazone (10 nM-1 mM; 30 min) reduces the proportion of phagocytic polymorphonuclear leukocytes and monocytes in peripheral blood from healthy donors and patients with soft tissue rheumatism, but does not alter the number of bacteria phagocytosed by individual cells^[1].

Innate Immunity

Oxidative Stress

Mofebutazone (10 nM-1 mM; 30 min) inhibits the release of respiratory burst oxidative products in peripheral blood leukocytes from healthy donors and patients with soft tissue rheumatism in a concentration-dependent manner^[1].

Lipid Inflammatory Mediators

Lipid Metabolism

Mofebutazone does not inhibit cyclooxygenase activity in isolated rat and human gastric mucosa^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS No. 41468-34-2
분자량 254.26
화학식 C₁₃H₁₅N₂NaO₂
SMILES

O=C(C1CCCC)[N-]N(C2=CC=CC=C2)C1=O.[Na+]
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Neumüller J, et al. Comparative in vitro investigations of the influence of mofebutazone, phenylbutazone and diclofenac on phagocytosis and respiratory burst of human peripheral blood leucocytes. Arzneimittel-Forschung. 1994 May;44(5):636-41. [Content Brief]

[2]. Coersmeier C, et al. Effect of anti-inflammatory and analgesic pyrazoles on arachidonic acid metabolism in isolated heart and gastric mucosa preparations. Agents and actions. Supplements. 1986;19:137-54. [Content Brief]

[3]. Lanz R, et al. The effects of acidic and nonacidic pyrazoles on arachidonic acid metabolism in mouse peritoneal macrophages. Agents and actions. Supplements. 1986;19:125-35. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

MOQ

Minimum order quantity

100 mg

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