Mofebutazone sodium
Mofebutazone sodium is a pyrazolidinedione non-steroidal anti-inflammatory agent (NSAID). Mofebutazone sodium exhibits weak COX inhibition, no effect on LOX, and slightly suppresses the percentage of leukocyte phagocytosis in vitro. Mofebutazone sodium can be used in research related to soft tissue rheumatism.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 41468-34-2
- 分子式: C13H15N2NaO2
- 分子量:254.26
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
Mofebutazone (10 nM-1 mM; 30 min) sodium reduces the proportion of phagocytic polymorphonuclear leukocytes and monocytes in peripheral blood from healthy donors and patients with soft tissue rheumatism, but does not alter the number of bacteria phagocytosed by individual cells[1].
Mofebutazone (10 nM-1 mM; 30 min) sodium inhibits the release of respiratory burst oxidative products in peripheral blood leukocytes from healthy donors and patients with soft tissue rheumatism in a concentration-dependent manner[1].
Mofebutazone sodium does not inhibit cyclooxygenase activity in isolated rat and human gastric mucosa[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 41468-34-2
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分子量 254.26
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分子式 C13H15N2NaO2
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SMILES
O=C(C1CCCC)[N-]N(C2=CC=CC=C2)C1=O.[Na+]
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Neumüller J, et al. Comparative in vitro investigations of the influence of mofebutazone, phenylbutazone and diclofenac on phagocytosis and respiratory burst of human peripheral blood leucocytes. Arzneimittel-Forschung. 1994 May;44(5):636-41. [Content Brief]
[2]. Coersmeier C, et al. Effect of anti-inflammatory and analgesic pyrazoles on arachidonic acid metabolism in isolated heart and gastric mucosa preparations. Agents and actions. Supplements. 1986;19:137-54. [Content Brief]
[3]. Lanz R, et al. The effects of acidic and nonacidic pyrazoles on arachidonic acid metabolism in mouse peritoneal macrophages. Agents and actions. Supplements. 1986;19:125-35. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Mofebutazone sodium 関連分類
HY-W009640A 関連分類
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