Mofebutazone sodium
Mofebutazone sodium is a pyrazolidinedione non-steroidal anti-inflammatory agent (NSAID). Mofebutazone sodium exhibits weak COX inhibition, no effect on LOX, and slightly suppresses the percentage of leukocyte phagocytosis in vitro. Mofebutazone sodium can be used in research related to soft tissue rheumatism.
For research use only. We do not sell to patients.
- CAS No.: 41468-34-2
- Formula: C13H15N2NaO2
- Molecular Weight:254.26
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Mofebutazone (10 nM-1 mM; 30 min) sodium reduces the proportion of phagocytic polymorphonuclear leukocytes and monocytes in peripheral blood from healthy donors and patients with soft tissue rheumatism, but does not alter the number of bacteria phagocytosed by individual cells[1].
Mofebutazone (10 nM-1 mM; 30 min) sodium inhibits the release of respiratory burst oxidative products in peripheral blood leukocytes from healthy donors and patients with soft tissue rheumatism in a concentration-dependent manner[1].
Mofebutazone sodium does not inhibit cyclooxygenase activity in isolated rat and human gastric mucosa[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 41468-34-2
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Molecular Weight 254.26
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Formula C13H15N2NaO2
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SMILES
O=C(C1CCCC)[N-]N(C2=CC=CC=C2)C1=O.[Na+]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Neumüller J, et al. Comparative in vitro investigations of the influence of mofebutazone, phenylbutazone and diclofenac on phagocytosis and respiratory burst of human peripheral blood leucocytes. Arzneimittel-Forschung. 1994 May;44(5):636-41. [Content Brief]
[2]. Coersmeier C, et al. Effect of anti-inflammatory and analgesic pyrazoles on arachidonic acid metabolism in isolated heart and gastric mucosa preparations. Agents and actions. Supplements. 1986;19:137-54. [Content Brief]
[3]. Lanz R, et al. The effects of acidic and nonacidic pyrazoles on arachidonic acid metabolism in mouse peritoneal macrophages. Agents and actions. Supplements. 1986;19:125-35. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Mofebutazone sodium Related Classifications
HY-W009640A Related Classifications
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