536-08-3
Chemical Structure
Digallic acid
- CAS. Nr.: 536-08-3
- Formula:C14H10O9
- Molecular Weight:322.22
IUPAC Name: 3,4-dihydroxy-5-((3,4,5-trihydroxybenzoyl)oxy)benzoic acid
InChIKey: COVFEVWNJUOYRL-UHFFFAOYSA-N
SMILES: OC(C1=CC(OC(C2=CC(O)=C(C(O)=C2)O)=O)=C(C(O)=C1)O)=O
Biological Activity: Digallic acid is an antioxidant, antimutagenic, antigenotoxic, and anti-hyperuricemic compound. Digallic acid is a reverse transcriptase and XOD, URAT1 (IC50: 5.34 μM) inhibitor. Digallic acid scavenges DPPH· and O2·− radicals. Digallic acid induces apoptosis. Digallic acid can be isolated from the fruits of Pistascia lentiscus[1][2][3].
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Digallic acid | Digallic acid is an antioxidant, antimutagenic, antigenotoxic, and anti-hyperuricemic compound. Digallic acid is a reverse transcriptase and XOD, URAT1 (IC50: 5.34 μM) inhibitor. Digallic acid scavenges DPPH· and O2·− radicals. Digallic acid induces apoptosis. Digallic acid can be isolated from the fruits of Pistascia lentiscus. | |||||||||||||||||||||
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- [1]. Bhouri W, et al. Digallic acid from Pistascia lentiscus fruits induces apoptosis and enhances antioxidant activities. Phytother Res. 2012 Mar;26(3):387-91. [Content Brief]
- [2]. Nakane H, et al. Differential inhibition of reverse transcriptase and various DNA polymerases by digallic acid and its derivatives. J Nat Prod. 1990 Sep-Oct;53(5):1234-40. [Content Brief]
- [3]. Zheng F, et al. Discovery of digallic acid as XOD/URAT1 dual target inhibitor for the treatment of hyperuricemia. Bioorg Chem. 2024 Jun;147:107381. [Content Brief]
Keywords
