2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
  4. Amino acid Transporter
  5. Amino acid Transporter Substrate

Amino acid Transporter Substrate

Amino acid Transporter Substrate (1):

Cat. No. Product Name Effect Purity
  • HY-183147A
    LAT1-IN-2 hydrochloride
    		Substrate
    LAT1-IN-2 hydrochloride is an orally active anticancer agent, as well as a LAT1 substrate and tubulin-binding agent. LAT1-IN-2 hydrochloride relies on LAT1 for cellular uptake, disrupts microtubule formation by binding to the colchicine site of tubulin, and induces actin depolymerization to transform cells into a spherical shape. LAT1-IN-2 hydrochloride effectively inhibits tumor growth in xenograft mice. Compared with Etoposide (HY-13629), LAT1-IN-2 hydrochloride shows higher distribution in tumor tissues, lower distribution in major organs, and better tolerability. LAT1-IN-2 hydrochloride has been applied in studies related to esophageal cancer.